Treatment of nephrotic idiopathic membranous nephropathy with monthly i.v. pulse cyclophosphamide and oral steroids: A single centre's retrospective study

Nephrology

Volumn 16, Issue 4, 2011, Pages 440-445

  Yuan, Jiangzi ^a   Fang, Wei ^a   Zhang, Weiming ^a   Ni, Zhaohui ^a   Qian, Jiaqi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Chinese patients; histology; i.v. pulse cyclophosphamide; idiopathic membranous nephropathy; nephrotic syndrome; prednisone

Indexed keywords

CYCLOPHOSPHAMIDE; PREDNISONE; STEROID;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIABETES MELLITUS; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HERPES ZOSTER; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LIVER FUNCTION; MALE; MEMBRANOUS GLOMERULONEPHRITIS; NAUSEA; NEPHROTIC IDIOPATHIC MEMBRANOUS NEPHROPATHY; PRIORITY JOURNAL; PROSTATE CANCER; RELAPSE; REMISSION; RESPIRATORY TRACT INFECTION; RETROSPECTIVE STUDY; SIDE EFFECT; STEROID THERAPY; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; AGED; CHI-SQUARE DISTRIBUTION; CHINA; CYCLOPHOSPHAMIDE; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PREDNISONE; PULSE THERAPY, DRUG; RECURRENCE; REMISSION INDUCTION; RETROSPECTIVE STUDIES; STEROIDS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79955420833     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2010.01427.x     Document Type: Article

References (25)

1. Haas M, Meehan SM, Karrison TG, Spargo BH,. Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976-1979 and 1995-1997. Am. J. Kidney Dis. 1997; 30: 621-31. (Pubitemid 27465355)
2. Hofstra JM, Branten AJ, Wirtz JJ, Noordzij TC, du Buf-Vereijken PW, Wetzels JF,. Early versus late start of immunosuppressive therapy in idiopathic membranous nephropathy: A randomized controlled trial. Nephrol. Dial. Transplant. 2010; 25: 129-36.
3. Murphy BF, McDonald I, Fairley KF, Kincaid-Smith PS,. Randomized controlled trial of cyclophosphamide, warfarin and dipyridamole in idiopathic membranous glomerulonephritis. Clin. Nephrol. 1992; 37: 229-34.
4. Jha V, Ganguli A, Saha TK, et al,. A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J. Am. Soc. Nephrol. 2007; 18: 1899-904. (Pubitemid 46870326)
5. Fraiser LH, Kanekal S, Kehrer JP,. Cyclophosphamide toxicity. Characterising and avoiding the problem. Drugs 1991; 42: 781-95. (Pubitemid 21920784)
6. Boumpas DT, Austin HA, 3rd, Fessler BJ, Balow JE, Klippel JH, Lockshin MD,. Systemic lupus erythematosus: Emerging concepts. Part 1: Renal, neuropsychiatric, cardiovascular, pulmonary, and hematologic disease. Ann. Intern. Med. 1995; 122: 940-50.
7. Dinant HJ, Decker JL, Klippel JH, Balow JE, Plotz PH, Steinberg AD,. Alternative modes of cyclophosphamide and azathioprine therapy in lupus nephritis. Ann. Intern. Med. 1982; 96: 728-36. (Pubitemid 12029340)
8. Fleischli ME, Valek RH, Pandya AG,. Pulse intravenous cyclophosphamide therapy in pemphigus. Arch. Dermatol. 1999; 135: 57-61. (Pubitemid 29069518)
9. Levey AS, Coresh J, Greene T, et al,. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann. Intern. Med. 2006; 145: 247-54. (Pubitemid 46768608)
10. Ponticelli C, Altieri P, Scolari F, et al,. A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J. Am. Soc. Nephrol. 1998; 9: 444-50. (Pubitemid 28122870)
11. Yao X, Chen H, Wang Q, et al,. Cyclosporin A treatment for idiopathic membranous nephropathy. Chin. Med. J. (Engl). 2001; 114: 1305-8. (Pubitemid 34041506)
12. Goumenos DS, Kalliakmani P, Tsakas S, Sotsiou F, Vlachojannis JG,. The remission of nephrotic syndrome with cyclosporin treatment does not attenuate the progression of idiopathic membranous nephropathy. Clin. Nephrol. 2004; 61: 17-24. (Pubitemid 38100839)
13. Cattran DC, Appel GB, Hebert LA, et al,. Cyclosporine in patients with steroid-resistant membranous nephropathy: A randomized trial. Kidney Int. 2001; 59: 1484-90. (Pubitemid 32281239)
14. Chen M, Li H, Li XY, et al,. Tacrolimus combined with corticosteroids in treatment of nephrotic idiopathic membranous nephropathy: A multicenter randomized controlled trial. Am. J. Med. Sci. 2010; 339: 233-8.
15. Praga M, Barrio V, Juarez GF, Luno J,. Tacrolimus monotherapy in membranous nephropathy: A randomized controlled trial. Kidney Int. 2007; 71: 924-30. (Pubitemid 46663803)
16. Austin HA, 3rd, Illei GG, Braun MJ, Balow JE,. Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy. J. Am. Soc. Nephrol. 2009; 20: 901-11.
17. Abe S, Amagasaki Y, Konishi K, Kato E, Iyori S, Sakaguchi H,. Idiopathic membranous glomerulonephritis: Aspects of geographical differences. J. Clin. Pathol. 1986; 39: 1193-8. (Pubitemid 17187735)
18. Gaarkeuken H, Siezenga MA, Zuidwijk K, et al,. Complement activation by tubular cells is mediated by properdin binding. Am. J. Physiol. Renal. Physiol. 2008; 295: F1397-403.
19. Abbate M, Zoja C, Corna D, et al,. Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury. J. Am. Soc. Nephrol. 2008; 19: 1158-67.
20. Troyanov S, Roasio L, Pandes M, Herzenberg AM, Cattran DC,. Renal pathology in idiopathic membranous nephropathy: A new perspective. Kidney Int. 2006; 69: 1641-8.
21. Polanco N, Gutierrez E, Covarsi A, et al,. Spontaneous remission of nephrotic syndrome in idiopathic membranous nephropathy. J. Am. Soc. Nephrol. 2010; 21: 697-704.
22. du Buf-Vereijken PW, Branten AJ, Wetzels JF,. Idiopathic membranous nephropathy: Outline and rationale of a treatment strategy. Am. J. Kidney Dis. 2005; 46: 1012-29. (Pubitemid 41690227)
23. Ponticelli C, Zucchelli P, Passerini P, et al,. A 10-year follow-up of a randomized study with methylprednisolone and chlorambucil in membranous nephropathy. Kidney Int. 1995; 48: 1600-4.
24. Reichert LJ, Huysmans FT, Assmann K, Koene RA, Wetzels JF,. Preserving renal function in patients with membranous nephropathy: Daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide. Ann. Intern. Med. 1994; 121: 328-33.
25. Pasricha JS, Thanzama J, Khan UK,. Intermittent high-dose dexamethasone-cyclophosphamide therapy for pemphigus. Br. J. Dermatol. 1988; 119: 73-7.