Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2602-2609

  Kolenc Peitl, Petra ^a   Mansi, Rosalba ^b,f   Tamma, Marialuisa ^b   Gmeiner Stopar, Tanja ^a   Sollner Dolenc, Marija ^d   Waser, Beatrice ^e   Baum, Richard P ^c   Reubi, Jean Claude ^e   Maecke, Helmut R ^b,f  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c Zentralklinik Bad Berka ^*  (Germany)

^d UNIVERSITY OF LJUBLJANA   (Slovenia)

^e UNIVERSITY OF BERN   (Switzerland)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID GASTRIN CONJUGATE GA 68; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID GASTRIN CONJUGATE IN 111; CHOLECYSTOKININ; GASTRIN; GASTRIN RECEPTOR; GLUTAMIC ACID; INDIUM 111; MACROGOL; TRACER; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CONJUGATION; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; HUMAN; IC 50; ISOTOPE LABELING; MALE; NONHUMAN; RAT;

ANIMALS; CALCIUM; CIRCULAR DICHROISM; HALF-LIFE; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; INDIUM RADIOISOTOPES; KIDNEY; RATS; RATS, INBRED LEW; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; TISSUE DISTRIBUTION;

EID: 79955405442     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101279a     Document Type: Article

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