The Influence of Bone Type on the Gene Expression in Normal Bone and at the Bone-Implant Interface: Experiments in Animal Model

Clinical Implant Dentistry and Related Research

Volumn 13, Issue 2, 2011, Pages 146-156

  Omar, Omar ^a   Suska, Felicia ^b   Lennerås, Maria ^c   Zoric, Neven ^d   Svensson, Sara ^e   Hall, Jan ^f   Emanuelsson, Lena ^a   Nannmark, Ulf ^a   Thomsen, Peter ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b TATAA Biocenter AB   (Sweden)

^c Nobel Biocare AB   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e Institute of Biomaterials and Cell Therapy   (Sweden)

^f BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy   (Sweden)

Author keywords

Cortical bone; Gene expression; In vivo; Titanium implants; Trabecular bone

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; AUTACOID; BIOMATERIAL; BIOMEDICAL AND DENTAL MATERIALS; CATHEPSIN K; CTSK PROTEIN, RAT; INTERLEUKIN 1BETA; ISOENZYME; OSTEOCALCIN; RNA 18S; TARTRATE-RESISTANT ACID PHOSPHATASE; TITANIUM; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ANIMAL MODEL; ARTICLE; BONE; BONE DENSITY; BONE DEVELOPMENT; BONE REMODELING; CHEMISTRY; COMPARATIVE STUDY; EPIPHYSIS; FEMALE; FEMUR; GENE EXPRESSION; GENETICS; HISTOLOGY; METABOLISM; OSTEOLYSIS; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RAT; SPRAGUE DAWLEY RAT; TOOTH IMPLANTATION;

ACID PHOSPHATASE; ALKALINE PHOSPHATASE; ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE DENSITY; BONE REMODELING; BONE RESORPTION; CATHEPSIN K; DENTAL IMPLANTS; DENTAL MATERIALS; EPIPHYSES; FEMALE; FEMUR; GENE EXPRESSION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; ISOENZYMES; MODELS, ANIMAL; OSTEOCALCIN; OSTEOGENESIS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, RIBOSOMAL, 18S; TITANIUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955400553     PISSN: 15230899     EISSN: 17088208     Source Type: Journal    
DOI: 10.1111/j.1708-8208.2009.00195.x     Document Type: Article

References (39)

1. Haider R, Watzek G, Plenk H. Effects of drill cooling and bone structure on IMZ implant fixation. Int J Oral Maxillofac Implants 1993; 8:83-91.
2. Davies JE. Understanding peri-implant endosseous healing. J Dent Educ 2003; 67:932-949.
3. Malmstrom J, Adolfsson E, Arvidsson A, Thomsen P. Bone response inside free-form fabricated macroporous hydroxyapatite scaffolds with and without an open microporosity. Clin Implant Dent Relat Res 2007; 9:79-88.
4. Mohammadi S, Esposito M, Hall J, Emanuelsson L, Krozer A, Thomsen P. Short-term bone response to titanium implants coated with thin radiofrequent magnetron-sputtered hydroxyapatite in rabbits. Clin Implant Dent Relat Res 2003; 5:241-253.
5. Omar O, Svensson S, Zoric N, etal. In vivo gene expression in response to anodically oxidized versus machined titanium implants. J Biomed Mater Res A 2009. (In press)
6. Gabbay JS, Heller J, Spoon DB, etal. Noggin underexpression and runx-2 overexpression in a craniosynostosis rabbit model. Ann Plast Surg 2006; 56:306-311.
7. Honsawek S, Powers RM, Wolfinbarger L. Extractable bone morphogenetic protein and correlation with induced new bone formation in an in vivo assay in the athymic mouse model. Cell Tissue Bank 2005; 6:13-23.
8. McKee MD, Farach-Carson MC, Butler WT, Hauschka PV, Nanci A. Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and alpha 2HS-glycoprotein) proteins in rat bone. J Bone Miner Res 1993; 8:485-496.
9. Pufe T, Scholz-Ahrens KE, Franke AT, etal. The role of vascular endothelial growth factor in glucocorticoid-induced bone loss: evaluation in a minipig model. Bone 2003; 33:869-876.
10. Wildemann B, Kadow-Romacker A, Pruss A, Haas NP, Schmidmaier G. Quantification of growth factors in allogenic bone grafts extracted with three different methods. Cell Tissue Bank 2007; 8:107-114.
11. Zhang J, Lu Y, Dai J, etal. In vivo real-time imaging of TGF-beta-induced transcriptional activation of the RANK ligand gene promoter in intraosseous prostate cancer. Prostate 2004; 59:360-369.
12. Hopwood B, Tsykin A, Findlay DM, Fazzalari NL. Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling. Arthritis Res Ther 2007; 9:R100.
13. Ikeda T, Nagai Y, Yamaguchi A, Yokose S, Yoshiki S. Age-related reduction in bone matrix protein mRNA expression in rat bone tissues: application of histomorphometry to in situ hybridization. Bone 1995; 16:17-23.
14. Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S. Expression profile of genes related to osteoclastogenesis in mouse growth plate and articular cartilage. Histochem Cell Biol 2006; 125:593-602.
15. Ozawa S, Ogawa T, Iida K, etal. Ovariectomy hinders the early stage of bone-implant integration: histomorphometric, biomechanical, and molecular analyses. Bone 2002; 30:137-143.
16. Schierano G, Canuto RA, Navone R, etal. Biological factors involved in the osseointegration of oral titanium implants with different surfaces: a pilot study in minipigs. J Periodontol 2005; 76:1710-1720.
17. Suttapreyasri S, Koontongkaew S, Phongdara A, Leggat U. Expression of bone morphogenetic proteins in normal human intramembranous and endochondral bones. Int J Oral Maxillofac Surg 2006; 35:444-452.
18. Zhu WQ, Wang X, Wang XX, Wang ZY. [Molecular mechanism of bone remodelling during mandibular distraction osteogenesis in rats. Zhonghua Kou Qiang Yi Xue Za Zhi 2007; 42:729-732. (In Chinese)
19. Masaki C, Schneider GB, Zaharias R, Seabold D, Stanford C. Effects of implant surface microtopography on osteoblast gene expression. Clin Oral Implants Res 2005; 16:650-656.
20. Schneider GB, Zaharias R, Seabold D, Keller J, Stanford C. Differentiation of preosteoblasts is affected by implant surface microtopographies. J Biomed Mater Res A 2004; 69:462-468.
21. Tan KS, Qian L, Rosado R, Flood PM, Cooper LF. The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Biomaterials 2006; 27:5170-5177.
22. Guo J, Padilla RJ, Ambrose W, De Kok IJ, Cooper LF. The effect of hydrofluoric acid treatment of TiO2 grit blasted titanium implants on adherent osteoblast gene expression in vitro and in vivo. Biomaterials 2007; 28:5418-5425.
23. Kochanowska I, Chaberek S, Wojtowicz A, etal. Expression of genes for bone morphogenetic proteins BMP-2, BMP-4 and BMP-6 in various parts of the human skeleton. BMC Musculoskelet Disord 2007; 8:128.
24. Preti G, Martinasso G, Peirone B, etal. Cytokines and growth factors involved in the osseointegration of oral titanium implants positioned using piezoelectric bone surgery versus a drill technique: a pilot study in minipigs. J Periodontol 2007; 78:716-722.
25. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132:365-386.
26. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29:e45.
27. Lo YJ, Liu CM, Wong MY, Hou LT, Chang WK. Interleukin 1beta-secreting cells in inflamed gingival tissue of adult periodontitis patients. Cytokine 1999; 11:626-633.
28. Zhou FH, Foster BK, Zhou XF, Cowin AJ, Xian CJ. TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats. J Bone Miner Res 2006; 21:1075-1088.
29. Roberts WE, Smith RK, Zilberman Y, Mozsary PG, Smith RS. Osseous adaptation to continuous loading of rigid endosseous implants. Am J Orthod 1984; 86:95-111.
30. Sennerby L, Thomsen P, Ericson LE. Early tissue response to titanium implants inserted in rabbit cortical bone: part I light microscopic observations. J Mater Sci Mater Med 1993; 4:240-250.
31. Lu JX, Gallur A, Flautre B, etal. Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits. J Biomed Mater Res 1998; 42:357-367.
32. Susin C, Qahash M, Hall J, Sennerby L, Wikesjo UM. Histological and biomechanical evaluation of phosphorylcholine-coated titanium implants. J Clin Periodontol 2008; 35:270-275.
33. Albrektsson T, Johansson C, Lundgren A-K, Sul Y-T, Gottlow J. Experimental studies on oxidized implants. A histomorphometrical and biomechanical analysis. Appl Osseointegration Res 2000; 1:21-24.
34. Gottlow J, Johansson C, Albrektsson T, Lundgren A-K. Biomechanical and histologic evaluation of the TiUnite and Osseotite implant surfaces in rabbits after 6 weeks of healing. Appl Osseointegration Res 2000; 1:25-30.
35. Rocci A, Martignoni M, Gottlow J. Immediate loading of Branemark System TiUnite and machined-surface implants in the posterior mandible: a randomized open-ended clinical trial. Clin Implant Dent Relat Res 2003; 5(Suppl 1):57-63.
36. Schupbach P, Glauser R, Rocci A, etal. The human bone-oxidized titanium implant interface: a light microscopic, scanning electron microscopic, back-scatter scanning electron microscopic, and energy-dispersive x-ray study of clinically retrieved dental implants. Clin Implant Dent Relat Res 2005; 7(Suppl 1):S36-S43.
37. Sul YT, Johansson C, Albrektsson T. Which surface properties enhance bone response to implants? Comparison of oxidized magnesium, TiUnite, and Osseotite implant surfaces. Int J Prosthodont 2006; 19:319-328.
38. Zechner W, Tangl S, Furst G, etal. Osseous healing characteristics of three different implant types. Clin Oral Implants Res 2003; 14:150-157.
39. Ivanoff CJ, Sennerby L, Lekholm U. Influence of initial implant mobility on the integration of titanium implants. An experimental study in rabbits. Clin Oral Implants Res 1996; 7:120-127.