Stability indicating RP-HPLC method development and validation of Sildenafil Citrate in pure form

International Journal of Research in Pharmaceutical Sciences

Volumn 2, Issue 2, 2011, Pages 187-191

  Mannur, V S ^a   Rathi, S M ^a   Mastiholimath, V S ^a   Dengale, N P ^a   Shinde, T A ^a  

^a K L E S S COLLEGE OF PHARMACY   (India)

Author keywords

HPLC method; Sildenafil citrate; Stability indicating; Validation

Indexed keywords

SILDENAFIL;

ACCURACY; ANALYTIC METHOD; ARTICLE; DRUG STABILITY; FLOW RATE; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 79955393329     PISSN: None     EISSN: 09757538     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Aboul-Enein. 'Rapid determination of sildenafil citrate in pharmaceutical preparations using monolithic sili-ca HPLC column' J Liquid Chromatography and Re-lated Technologies, vol. 26, no. 17, 2003 pp. 2897-2908.
2. Al-Omari, M. 'Determination of sildenafil citrate and related substances in the commercial products and tablet dosage form using HPLC', J Pharmaceut Bio-med Anal, 2001, 25: 483-492.
3. ICH Q1B Photostability testing of new active sub-stances and medicinal products.
4. ICH Q2B Validation of Analytical Procedures: Metho-dology International Conference on Harmonisation of Technical requirements for registration of Pharma-ceuticals for Human use, Geneva, Swizterland, 1996.
5. Indian Pharmacopoeia 2010, Volume III, Published by the controller of Publication, Ministry of Health and Family welfare, New Delhi, pp.2100-2102.
6. Rangappa, K.S. 'Stability indicating RP-LC determination of sildenafil citrate (viagra) in pure form and in phar-maceutical samples', J Pharmaceut Biomed Anal, 2002, 29: 743-748.
7. Reddy, P.B. & Reddy, R.Y. 'Validation and stability indi-cating RP-HPLC method for the determination of sil-denafil citrate in pharmaceutical formulations and human plasma', E-J.Chem, vol. 5, no. 52, 2008 pp. 1117-1122, Available: http://www.e-journals.net/0973-4945, [10 May 2008].
8. Yada, D. 'Method development and validation of stabil-ity indicating methods for assay of tadalafil ans silde-nafil citrate by HPLC', Int J of ChemTech Research, vol. 2, no. 1, Jan-Mar, 2010 pp. 329-333.