Isolation of marinobufotoxin from the supernatant of cultured PC12 cells

Clinical and Experimental Pharmacology and Physiology

Volumn 38, Issue 5, 2011, Pages 334-337

  Yoshika, Masamichi ^a   Komiyama, Yutaka ^a   Takahashi, Hakuo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Adrenal medulla; ELISA; Endogenous digitalis; Marinobufotoxin; PC12 cells

Indexed keywords

ADRENOMEDULLIN; ARGININE ESTERASE; MARINOBUFAGENIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL STRAIN; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; NONHUMAN; RAT; SUPERNATANT; TANDEM MASS SPECTROMETRY;

ADRENAL GLAND NEOPLASMS; ANIMALS; CARDANOLIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; MASS SPECTROMETRY; PC12 CELLS; PHEOCHROMOCYTOMA; RATS; TUMOR CELLS, CULTURED;

EID: 79955386596     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05512.x     Document Type: Article

References (34)

1. Fedorova OV, Shapiro JI, Bagrov AY. Endogenous cardiotonic steroids and salt-sensitive hypertension. Biochim. Biophys. Acta. 2010; 1802: 1230-6.
2. Schoner W, Scheiner-Bobis G. Endogenous and exogenous cardiac glycosides. Their roles in hypertension, salt metabolism, and cell growth. Am. J. Physiol. Cell Physiol. 2007; 293: C509-36.
3. Hamlyn JM, Blaustein MP, Bova S et al. Identification and characterization of an ouabain-like compound from human plasma. Proc. Natl Acad. Sci. USA 1991; 88: 6259-63.
4. Bauer N, Muller-Ehmsen J, Kramer U et al. Ouabain-like compound changes rapidly on physical exercise in humans and dogs. Hypertension 2005; 45: 1024-8.
5. +-ATPase inhibitor in patients after acute myocardial infarction. Hypertension 1998; 31: 1097-103.
6. Komiyama Y, Dong XH, Nishimura N et al. A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clin. Biochem. 2005; 38: 36-45.
7. Yoshika M, Komiyama Y, Konishi M et al. Novel digitalis-like factor, marinobufotoxin, isolated from cultured Y-1 cells, and its hypertensive effect in rats. Hypertension 2007; 49: 209-14.
8. Yamada H, Naruse M, Naruse K et al. Histological study on ouabain immunoreactivities in the mammalian hypothalamus. Neurosci. Lett. 1992; 141: 143-6.
9. Kawamura A, Guo J, Itagaki Y et al. On the structure of endogenous ouabain. Proc. Natl Acad. Sci. USA 1999; 96: 6654-9.
10. Kawamura A, Abrell LM, Maggiali F et al. Biological implication of conformational flexibility in ouabain: Observations with two ouabain phosphate isomers. Biochemistry 2001; 40: 5835-44.
11. Perrin A, Brasmes B, Chambaz EM, Defaye G. Bovine adrenocortical cells in culture synthesize an ouabain-like compound. Mol. Cell. Endocrinol. 1997; 126: 7-15.
12. Schneider R, Wray V, Nimtz M et al. Bovine adrenals contain, in addition to ouabain, a second inhibitor of the sodium pump. J. Biol. Chem. 1998; 273: 784-92.
13. Laredo J, Hamilton BP, Hamlyn JM. Secretion of endogenous ouabain from bovine adrenocortical cells: Role of the zona glomerulosa and zona fasciculata. Biochem. Biophys. Res. Commun. 1995; 212: 487-93.
14. Komiyama Y, Mori T, Okuda K et al. Effects of intracerebroventricular administration of 6-hydroxydopamine on ouabain-like immunoreactivity in plasma and the hypothalamo-pituitary axis in rats. J. Hypertens. 1996; 14: 447-52.
15. Takahashi H, Ihara N, Terano Y, Yamada H, Nishimura M, Nakanishi T. Ouabain-like immunoreactive substances exist in the hypothalamus and the adrenal medulla in rats. Pathophysiology 1994; 1: 25-8.
16. Komiyama Y, Nishimura N, Munakata M et al. Increases in plasma ouabainlike immunoreactivity during surgical extirpation of pheochromocytoma. Hypertens. Res. 1999; 22: 135-9.
17. Komiyama Y, Nishimura N, Munakata M et al. Identification of endogenous ouabain in culture supernatant of PC12 cells. J. Hypertens. 2001; 19: 229-36.
18. Komiyama Y, Nishimura N, Dong XH et al. Liquid chromatography mass spectrometric analysis of ouabainlike factor in biological fluid. Hypertens. Res. 2000; 23(Suppl.): S21-7.
19. Fridman AI, Matveev SA, Agalakova NI, Fedorova OV, Lakatta EG, Bagrov AY. Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. J. Hypertens. 2002; 20: 1189-94.
20. Fedorova OV, Talan MI, Agalakova NI, Lakatta EG, Bagrov AY. Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride-dependent hypertension. Circulation 2002; 105: 1122-7.
21. Fedorova OV, Kolodkin NI, Agalakova NI et al. Antibody to MBG lowers blood pressure in pregnant rats on a high NaCl intake. J. Hypertens. 2005; 23: 835-42.
22. Dmitrieva RI, Bagrov AY, Lalli E, Sassone-Corsi P, Stocco DM, Doris PA. Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage. Hypertension 2000; 36: 442-8.
23. Matsukawa M, Mukai T, Akizawa T et al. Isolation and characterization of novel endogenous digitalis-like factors in the ovary of the giant toad, Bufo marinus. J. Nat. Prod. 1998; 61: 1476-81.
24. i-independent signaling in C7-MDCK cells. J. Biol. Chem. 2005; 280: 832-9.
25. Hamlyn JM, Laredo J, Shah JR, Lu ZR, Hamilton BP. 11-Hydroxylation in the biosynthesis of endogenous ouabain: Multiple implications. Ann. NY Acad. Sci. 2003; 986: 685-93.
26. Shimojo M, Whorwood CB, Stewart PM. 11beta-Hydroxysteroid dehydrogenase in the rat adrenal. J. Mol. Endocrinol. 1996; 17: 121-30.
27. Murrell JR, Randall JD, Rosoff J et al. Endogenous ouabain: Upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Circulation 2005; 112: 1301-8.
28. Brown N, Swart P, Fenhalls G et al. Baboon CYP11B1: The localization and catalytic activity in baboon adrenal tissue. Endocr. Res. 2002; 28: 477-84.
29. Carballeira A, Fishman LM. Steroid enzyme activities in extraadrenal pheochromocytomas. J. Clin. Endocrinol. Metab. 1982; 54: 619-24.
30. Shimada K, Miyashiro Y, Nishio T. Characterization of in vitro metabolites of toad venom using high-performance liquid chromatography and liquid chromatography-mass spectrometry. Biomed. Chromatogr. 2006; 20: 1321-7.
31. Miyashiro Y, Nishio T, Shimada K. Characterization of in vivo metabolites of toad venom using liquid chromatography-mass spectrometry. J. Chromatogr. Sci. 2008; 46: 534-8.
32. +] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet. Am. J. Physiol. Heart Circ. Physiol. 2004; 287: H1160-6.
33. Zhao X, White R, Huang BS, Van Huysse J, Leenen FH. High salt intake and the brain renin-angiotensin system in Dahl salt-sensitive rats. J. Hypertens. 2001; 19: 89-98.
34. Leenen FH. The central role of the brain aldosterone-'ouabain' pathway in salt-sensitive hypertension. Biochim. Biophys. Acta. 2010; 1802: 1132-9.