A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells

Journal of Biomolecular Screening

Volumn 16, Issue 4, 2011, Pages 383-393

  Li, Hui Fang ^a   Keeton, Adam ^b   Vitolo, Michele ^c   Maddox, Clinton ^b   Rasmussen, Lynn ^b   Hobrath, Judith ^b   Lucille White, E ^b   Ben Ho Park, ^d   Piazza, Gary A ^b   Kim, Jung Sik ^a   Waldman, Todd ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

DNA damage; high throughput screen; human somatic cell gene targeting; phenotypic screen; PIK3CA; PTEN; synthetic lethality

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIBIOTIC G 418; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CID 1340132; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; HYDRAZIDE DERIVATIVE; HYGROMYCIN; N' [(1 BENZYL 1H INDOL 3 YL)METHYLENE]BENZENESULFONOHYDRAZIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN PIK3CA; UNCLASSIFIED DRUG; WORTMANNIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ASSAY; CELL PROLIFERATION; CELL VIABILITY; CYTOTOXICITY; DNA DAMAGE; DNA SYNTHESIS; GENE MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDOLES; MUTATION; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REPRODUCIBILITY OF RESULTS; SULFONAMIDES;

EID: 79955384194     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110397357     Document Type: Article

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