Defining rare variants by their frequencies in controls may increase type i error

Nature Genetics

Volumn 43, Issue 5, 2011, Pages 391-392

  Lemire, Mathieu ^a  

^a ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; HEREDITY; HUMAN; HYPERTRIGLYCERIDEMIA; LETTER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN VARIANT; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; CASE-CONTROL STUDIES; COMPUTER SIMULATION; GENE FREQUENCY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERTRIGLYCERIDEMIA; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79955372100     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.818     Document Type: Letter

References (5)

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3. Madsen, B.E. & Browning, S.R. PLoS Genet. 5, e1000384 (2009).
4. Li, B. & Leal, S.M. Am. J. Hum. Genet. 83, 311-321 (2008).
5. Sasieni, P.D. Biometrics 53, 1253-1261 (1997).