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Palladacycles based upon biarylmonophosphines are operationally simple to handle precatalysts which are, easily acivated and ensure formation of the catalytically active monoligated Pd(0 species.
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No product formation was observed without ligand or without palladium source under the reaction conditions.
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For the role of LiHMDS as a base to enable Pd-catalyzed C,Ncross coupling reactions in the presence of functional groups with acidic protons
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Product configuration was confirmed by NOE experiment
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Product configuration was confirmed by NOE experiment.
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The prefered C,N-cross coupling in position 3 is in accordance with selectivities observed in C,C-cross coupling reactions
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For the origin of regioselectivity in Pd-catalyzed cross-coupling reactions of polyhalogenated heterocycles.
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