The use of human embryonic stem cells in drug discovery

Clinical Pharmacology and Therapeutics

Volumn 89, Issue 5, 2011, Pages 641-643

  Esteso, P ^a   Gearhart, J D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

DRUG RESEARCH; DRUG SCREENING; EMBRYONIC STEM CELL; GOLD STANDARD; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW;

DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; EMBRYONIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS;

EID: 79955367117     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.19     Document Type: Review

References (7)

1. Ding, S. et al. Synthetic small molecules that control stem cell fate. Proc. Natl. Acad. Sci. USA 100, 7632-7637 (2003). (Pubitemid 36760021)
2. McNeish, J. et al. High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5- methyl-4-isoxazolepropionate-type glutamate receptors. J. Biol. Chem. 285, 17209-17217 (2010).
3. Desbordes, S.C. et al. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2, 602-612 (2008). (Pubitemid 351729221)
4. Xu, Y. et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. USA 107, 8129-8134 (2010).
5. Tzukerman, M. et al. The influence of a human embryonic stem cell-derived microenvironment on targeting of human solid tumor xenografts. Cancer Res 66, 3792-3801 (2006).
6. Karumbayaram, S., Et al. Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS. Dis. Model Mech. 2, 189-195 (2009).
7. Jensen, J., Hyllner, J. & Björquist, P. Human embryonic stem cell technologies and drug discovery. J. Cell Physiol. 219, 513-519 (2009).