High prevalence of coronary calcifications and increased risk for coronary heart disease in adults with growth hormone deficiency

Journal of Endocrinological Investigation

Volumn 34, Issue 1, 2011, Pages 32-37

  Cannavo S ^a   Marini, F ^a   Curtò, Lorenzo ^a   Torre, M L ^a   De Gregorio, C ^b   Salamone, I ^a   Alibrandi, A ^a   Trimarchi, F ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Agatston score; Cardiovascular risk; Framingham score; GH; Hypopituitarism; IGF I

Indexed keywords

CORTISONE ACETATE; DESMOPRESSIN; LEVOTHYROXINE; SEX HORMONE; SOMATOMEDIN C;

ADULT; ARTERY CALCIFICATION; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; HYPERINSULINISM; HYPERTENSION; HYPOPITUITARISM; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY;

ADULT; AGED; CALCINOSIS; CARDIOMYOPATHIES; CASE-CONTROL STUDIES; CORONARY DISEASE; CORONARY VESSELS; FEMALE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; MALE; MIDDLE AGED; PREVALENCE; RISK FACTORS;

EID: 79955366164     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7076     Document Type: Article

References (19)

1. Leonsson M, Hulthe J, Oscarsson J, et al. Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors. Clin Endocrinol (Oxf) 2002, 57: 751-9. (Pubitemid 36963003)
2. Oflaz H, Sen F, Elitok A, et al. Coronary flow reserve is impaired in patients with adult growth hormone (GH) deficiency. Clin Endocrinol (Oxf) 2007, 66: 524-9. (Pubitemid 46434934)
3. Juul A, Scheike T, Davidsen M, Gyllenborg J, Jørgensen T. Low serum Insulin-Like Growth Factor I is associated with increased risk of ischemic heart disease. A population based case-control study. Circulation 2002, 106: 939-44. (Pubitemid 34925327)
4. Maison P, Griffin S, Nicoue-Beglah M, Haddad N, Balkau B, Chanson P. Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a metaanalysis of blinded, randomized, placebo-controlled trials. J Clin Endocrinol Metab 2004, 89: 2192-9. (Pubitemid 38619852)
5. Burger AG, Monson JP, Colao AM, Klibanski A. Cardiovascular risk in patients with growth hormone deficiency: effects of growth hormone substitution. Endocr Pract 2006, 12: 682-9.
6. Abdul Shakoor SK, Shalet SM. Effects of GH replacement on metabolism and physical performance in GH deficient adults. J Endocrinol Invest 2003, 26: 911-8. (Pubitemid 38049174)
7. Becker CR, Majeed A, Crispin A, et al. CT measurement of coronary calcium mass: impact on global cardiac risk assessment. Eur Radiol 2005, 15: 96-101. (Pubitemid 40109777)
8. Budoff MJ, Shaw LJ, Liu ST, et al. Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. J Am Coll Cardiol 2007, 49: 1860-70. (Pubitemid 46661110)
9. Cannavò S, Almoto B, Cavalli G, et al. Acromegaly and coronary disease: an integrated evaluation of conventional coronary risk factors and coronary calcifications detected by computed tomography. J Clin Endocrinol Metab 2006, 91: 3766-72. (Pubitemid 44536841)
10. Pletcher MJ, Tice JA, Pignone M, Browner WS. Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch Intern Med 2004, 164: 1285-92. (Pubitemid 38828878)
11. Budoff MJ, Nasir K, McClelland RL, et al. Coronary calcium predicts events better with absolute calcium scores than age-sex-race/ethnicity percentiles: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2009, 53: 345-52.
12. Tomlinson JW, Holden N, Hills RK, et al. Association between premature mortality and hypopituitarism. Lancet 2001, 357: 425-31. (Pubitemid 32156141)
13. Conti E, Carrozza C, Capoluongo E, et al. Insulin-like growth factor-1 as a vascular protective factor. Circulation 2004, 110: 2260-5. (Pubitemid 39372511)
14. Greenland P, Gaziano JM. Clinical practice. Selecting asymptomatic patients for coronary computed tomographic exercise testing. N Engl J Med 2003, 349: 465-73. (Pubitemid 36910026)
15. Abdu TAM, Neary R, Elhadd TA, Akber M, Clayton RN. Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities. Clin Endocrinol (Oxf) 2001, 55: 209-16. (Pubitemid 32868585)
16. Abdu TAM, Elhadd TA, Buch H, Barton D, Neary R, Clayton RN. Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk. Clin Endocrinol (Oxf) 2004, 61: 387-93. (Pubitemid 39287070)
17. Greenland P, Bonow RO, Brundage BH, et al. American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography); Society of Atherosclerosis Imaging and Prevention; Society of Cardiovascular Computed Tomography. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain. J Am Coll Cardiol 2007, 49: 378-402.
18. Colao A, Di Somma C, Cuocolo A, et al. Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency. J Clin Endocrinol Metab 2005, 90: 5146-55. (Pubitemid 41262267)
19. Centro di Epidemiologia, Sorveglianza e Promozione della Salute - Istituto Superiore di Sanità. La mortalità per causa in Italia: 1980-2002. www.iss.it/site/mortalita.