The temporal fate of drugs in decomposing porcine tissue

Journal of Forensic Sciences

Volumn 56, Issue 3, 2011, Pages 694-699

  Wyman, John F ^a,b,d   Dean, Dorothy E ^b   Yinger, Rachel ^a   Simmons, Amber ^a   Brobst, David ^a   Bissell, Michael ^b   Silveira, Fernando ^c   Kelly, Nancy ^a   Shott, Robert ^b   Ohr, Joseph ^a   Howard, Rick ^c   Lewis, Bradley ^a  

^a Franklin County Coroner's Office   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d Cuyahoga County Regional Forensic Science Laboratory   (United States)

Author keywords

Blood; Decomposing tissue; Drugs; Forensic science; Liver; Muscle; Pig

Indexed keywords

DRUG;

ANIMAL; ARTICLE; BRAIN LEVEL; CADAVER; CHEMISTRY; FORENSIC TOXICOLOGY; KIDNEY; LIVER; MASS FRAGMENTOGRAPHY; PHARMACOKINETICS; SKELETAL MUSCLE; SOIL; SWINE; TIME; TISSUE DISTRIBUTION;

ANIMALS; BRAIN CHEMISTRY; FORENSIC TOXICOLOGY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KIDNEY; LIVER; MUSCLE, SKELETAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; POSTMORTEM CHANGES; SOIL; SWINE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 79955149450     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2011.01725.x     Document Type: Article

References (18)

1. Paterson S. Drugs and decomposition. Med Sci Law 1993;33(2):103-9.
2. Drummer OH, Gerostamoulos J. Postmortem drug analysis: analytical and toxicological aspects. Ther Drug Monit 2002;24(2):199-209.
3. Pélissier-Alicot AL, Gaulier JM, Champsaur P, Marquet P. Mechanisms underlying postmortem redistribution of drugs: a review. J Anal Toxicol 2003;27(8):533-44.
4. Drummer OH. Postmortem toxicology of drugs of abuse. Forensic Sci Int 2004;142(2-3):109-13.
5. Flanagan RJ, Connally G. Interpretation of analytical toxicology results in life and at postmortem. Toxicol Rev 2005;24(1):51-62.
6. Drummer OH. Post-mortem toxicology. Forensic Sci Int 2007;165(2-3):199-203.
7. McIntyre LM, King CV, Boratto M, Drummer OH. Post-mortem drug analyses in bone and bone marrow. Ther Drug Monit 2000;22(1):79-83.
8. Flanagan RJ, Amin A, Seinen W. Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozaine concentrations in the domestic pig (Sus Scrofa). Forensic Sci Int 2003;132(1):9-17.
9. Pond WG, Mersmann HJ, editors. Biology of the domestic pig. Ithica, NY: Comstock Pub, 2001.
10. Stevens HM. The stability of some drugs and poisons in putrefying human liver tissues. J Forensic Sci Soc 1984;24:577-89.
11. Baselt RC, editor. Disposition of toxic drugs and chemicals in man, 6th edn. Foster City, CA: Biomedical Pub, 2002.
12. Winek's Drug and Chemical Blood-Level Data 2001,
13. Amendt J, Krettek R, Zehner R. Forensic entomology. Naturwissenschaften 2004;91:51-65.
14. UCT, Inc. Therapeutic and abused drugs in plasma/serum and urine for acid/neutral and basic drugs for GC or GC/MS confirmations using: 200mg Clean Screen® extraction columns. In: ????? ?????, editors. 2009 UCT Solid Phase Extraction Applications Manual. Bristol, PA: UCT, Inc., 2008;42-3.
15. Dolinak D. Toxicology. In: Dolinak D, Matshes EW, Lew EO, editors. Forensic pathology principles and practice. London, U.K.: Elsevier Academic Press, 2005;489.
16. Lewis R, Johnson RD, Southern TL, Canfield DV. Distribution of butalbital in postmortem tissues and fluids from non-overdose cases. J Anal Toxicol 2003;27(3):145-8.
17. Garriott JC. Skeletal muscle as an alternative specimen for alcohol and drug analysis. J Forensic Sci 1991;36(1):60-9.
18. Shiota H, Nakashima M, Terazono H, Sasaki H, Nishida K, Nakamura J, et al. Postmortem changes in tissue concentrations of triazolam and diazepam in rats. Leg Med (Tokyo) 2004;6(4):224-32.