Evaluation of the effect of acetyl L-carnitine on experimental cisplatin ototoxicity and neurotoxicity

Chemotherapy

Volumn 57, Issue 3, 2011, Pages 186-194

  Gunes, Dilek ^a   Kirkim, Günay ^a   Kolatan, Efsun ^a   Guneri, Enis Alpin ^a   Ozogul, Candan ^c   Altun, Zekiye ^b   Serbetcioglu, Bülent ^a   Yilmaz, Osman ^a   Aktas, Safiye ^b   Mutafoglu, Kamer ^a   Tufekci, Ozlem ^a   Erbayraktar, Zübeyde ^b   Olgun, Nur ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b Institute of Oncology   (Turkey)

^c GAZI UNIVERSITY   (Turkey)

Author keywords

Acetyl L carnitine; Apoptosis; Cisplatin neurotoxicity; Cisplatin ototoxicity; Ultrastructural findings

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CISPLATIN; LEVACECARNINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; HAIR CELL; HEARING TEST; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; NEUROTOXICITY; NICK END LABELING; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ACETYLCARNITINE; ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; CASPASE 3; CASPASE 8; CASPASE 9; CISPLATIN; EAR, MIDDLE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; HAIR CELLS, AUDITORY; HEARING DISORDERS; ORGAN OF CORTI; RATS; RATS, WISTAR; VITAMIN B COMPLEX;

EID: 79955120403     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000323621     Document Type: Article

References (36)

1. Adamson PC, Balis FM, Berg S, Blaney SM: General principles of chemotherapy; in Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology. Philadelphia, Lippincott, Williams & Wilkins, 2006, pp 290-365.
2. Bertolini P, Lassalle M, Mercier G, Raquin MA, Izzi G, Corradini N, Hartmann O: Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss. J Pediatr Hematol Oncol 2004;26:649-655. (Pubitemid 39350398)
3. Brock P, Pritchard J, Bellman S, Pinkerton CR: Ototoxicity of high-dose cis-platinum in children. Med Pediatr Oncol 1988;16:368-369.
4. Brock PR, Bellman SC, Yeomans EC, Pinkerton CR, Pritchard J: Cisplatin ototoxicity in children: a practical grading system. Med Pediatr Oncol 1991;19:295-300.
5. McHaney VA, Thibadoux G, Hayes FA, Green AA: 1983. Hearing loss in children receiving cisplatin chemotherapy. J Pediatr 1983;102:314-317. (Pubitemid 13194726)
6. Skinner R: Best practice in assessing ototox-icity in children with cancer. Eur J Cancer 2004;40:2352-2354. (Pubitemid 39424946)
7. Clerici WJ, Hensley K, DiMartino DL, Butterfield DA: Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants. Hear Res 1996;98:116-124. (Pubitemid 26306760)
8. Rybak LP, Husain K, Morris C, Whitworth C, Somani S: Effect of protective agents against cisplatin ototoxicity. Am J Otol 2000;21:513-520. (Pubitemid 30432460)
9. Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V: Mechanisms of cisplatin-in-duced ototoxicity and prevention. Hear Res 2007;226:157-167.
10. Kitada N, Takara K, Itoh C, Minegaki T, Tsujimoto M, Sakaeda T, Yokoyama T: Comparative analysis of cell injury after exposure to antitumor platinum derivatives in kidney tubular epithelial cells. Chemotherapy 2008;54:217-223. (Pubitemid 351929273)
11. Yin HY, Ma XF, Liu F, Xia M, Xu AT: Protective effect of geranylgeranylacetone on cis-platin ototoxicity. Chemotherapy 2009;55:1-5.
12. Bremer J: Carnitine-metabolism and functions. Physiol Rev 1983;63:1420-1480.
13. Calabrese V, Giuffrida Stella AM, Calvani M, Butterfield DA: Acetylcarnitine and cellular stress response: roles in nutritional redox ho-meostasis and regulation of longevity genes. J Nutr Biochem 2006;17:73-88. (Pubitemid 43082141)
14. Bianchi G, Vitali G, Caraceni A, Ravaglia S, Capri G, Cundari S, Zanna C, Gianni L: Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. Eur J Cancer 2005;41:1746-1750. (Pubitemid 41132636)
15. De Grandis D: Acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy: a short review. CNS Drugs 2007;21(suppl 1):39-43, discussion 45-46.
16. Maestri A, De Pasquale Ceratti A, Cundari S, Zanna C, Cortesi E, Crinò L: A pilot study on the effect of acetyl- L -carnitine in pacli-taxel- and cisplatin-induced peripheral neuropathy. Tumori 2005;91:135-138. (Pubitemid 40705085)
17. Pisano C, Pratesi G, Laccabue D, Zunino F, Lo Giudice P, Bellucci A, Pacifici L, Camerini B, Vesci L, Castorina M, Cicuzza S, Tredici G, Marmiroli P, Nicolini G, Galbiati S, Calvani M, Carminati P, Cavaletti G: Paclitaxel and cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. Clin Cancer Res 2003;9:5756-5767. (Pubitemid 37499500)
18. Altun ZS, Güneş D, Aktaş S, Erbayraktar Z, Olgun N: Protective effects of acetyl- L-car-nitine on cisplatin cytotoxicity and oxidative stress in neuroblastoma. Neurochem Res 2010;35:437-443.
19. Di Cesare Mannelli L, Ghelardini C, Calvani M, Nicolai R, Mosconi L, Vivoli E, Pacini A, Bartolini A: Protective effect of acetyl-L-car-nitine on the apoptotic pathway of peripheral neuropathy. Eur J Neurosci 2007;26:820-827. (Pubitemid 47274617)
20. Pillich RT, Scarsella G, Risuleo G: Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-L-carnitine to mouse fibroblasts in culture. Exp Cell Res 2005;306:1-8. (Pubitemid 40692766)
21. Zhu X, Sato EF, Wang Y, Nakamura H, Yodoi J, Inoue M: Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells. Arch Biochem Biophys 2008;478:154-160.
22. Tüfekçi Ö, Gunes D, Özoǧul C, Kolatan E, Altun Z, Yilmaz O, Aktaş S, Erbayraktar Z, Kirkim G, Mutafoǧlu K, Soylu A, Şerbetçioǧlu B, Güneri EA, Olgun N: Evaluation of the effect of acetyl-L-carnitine on experimental cisplatin nephrotoxicity. Chemotherapy 2009;55:451-459.
23. Akdogan O, Selcuk A, Take G, Erdoǧan D, Dere H: Continuous or intermittent noise exposure, does it cause vestibular damage? An experimental study. Auris Nasus Larynx 2009;36:2-6.
24. Kopke RD, Liu W, Gabaizadeh R, Jacono A, Feghali J, Spray D, Garcia P, Steinman H, Malgrange B, Ruben RJ, Rybak L, Van de Water TR: Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-in-duced damage of auditory hair cells. Am J Otol 1997;18:559-571. (Pubitemid 27428342)
25. Liu W, Staecker H, Stupak H, Malgrange B, Lefebvre P, Van De Water TR: Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport 1998;9:2609-2614. (Pubitemid 28387158)
26. Huang T, Cheng AG, Stupak H, Liu W, Kim A, Staecker H, Lefebvre PP, Malgrange B, Kopke R, Moonen G, Van De Water TR: Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci 2000;18:259-270. (Pubitemid 30129199)
27. Cardinaal RM, de Groot JC, Huizing EH, Veldman JE, Smoorenburg GF: Dose-dependent effect of 8-day cisplatin administration upon the morphology of the albino guinea pig cochlea. Hear Res 2000;144:135-146. (Pubitemid 30301682)
28. Jordan P, Carmo-Fonseca M: Molecular mechanisms involved in cisplatin cytotoxic-ity. Cell Mol Life Sci 2000;57:1229-1235. (Pubitemid 30663480)
29. Huang X, Whitworth CA, Rybak LP: Ginkgo biloba ext ract (EGb 761) protects a gainst cis-platin-induced ototoxicity in rats. Otol Neurotol 2007;28:828-833. (Pubitemid 47329900)
30. Alam SA, Ikeda K, Oshima T, Suzuki M, Kawase T, Kikuchi T, Takasaka T: Cisplat in-induced apoptotic cell death in Mongolian gerbil cochlea. Hear Res 2000;141:28-38. (Pubitemid 30125313)
31. Teranishi M, Nakashima T, Wakabayashi T: Effects of alpha-tocopherol on cisplatin-in-duced ototoxicity in guinea pigs. Hear Res 2001;151:61-70.
32. Ashkenazi A, Dixit VM: Death receptors: signaling and modulation. Science 1998;281:1305-1308. (Pubitemid 28406815)
33. Gross A, McDonnell JM, Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999;13:1899-1911. (Pubitemid 29407357)
34. Harris MH, Thompson CB: The role of the Bcl-2 family in the regulation of outer mito-chondrial membrane permeability. Cell Death Differ 2000;7:1182-1191. (Pubitemid 32042225)
35. Thornberry NA, Lazebnik Y: Caspases: enemies within. Science 1998;281:1312-1316. (Pubitemid 28406817)
36. Matsui JI, Ogilvie JM, Warchol ME: Inhibition of caspases prevents ototoxic and ongoing hair cell death. J Neurosci 2002;22:1218-1227. (Pubitemid 34163723)