Targeting metabolomics analysis of the sunscreen agent 2-ethylhexyl 4-(N,N-dimethylamino)benzoate in human urine by automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry with liquid chromatography-time-of-flight/mass spectrometry confirmation

Journal of Chromatography A

Volumn 1218, Issue 20, 2011, Pages 3013-3021

  León González, Zacarías ^a   Ferreiro Vera, Carlos ^b   Priego Capote, Feliciano ^b   Luque de Castro, María Dolores ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

2 Ethylhexyl 4 (N,N dimethylamino)benzoate; LC MS MS; Metabolism; On line solid phase extraction; Percutaneous absorption; Urine

Indexed keywords

2-ETHYLHEXYL 4-(N,N-DIMETHYLAMINO)BENZOATE; LC-MS/MS; ON-LINE SOLID PHASE EXTRACTION; PERCUTANEOUS ABSORPTION; URINE;

ABSORPTION; BODY FLUIDS; DETOXIFICATION; ENZYMATIC HYDROLYSIS; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHYSIOLOGY; SOLVENT EXTRACTION; SUN HOODS;

LIQUID CHROMATOGRAPHY;

2 ETHYLHEXYL 4 (N,N DIMETHYLAMINO)BENZOATE; 4 (N METHYLAMINO)BENZOIC ACID; 4 (N,N DIMETHYLAMINO)BENZOIC ACID; BENZOIC ACID DERIVATIVE; DRUG METABOLITE; SUNSCREEN; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; AUTOMATION; CALIBRATION; CONTROLLED STUDY; DETOXIFICATION; DRUG METABOLISM; FEMALE; HUMAN; IN VIVO STUDY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; METABOLOMICS; ONLINE SYSTEM; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; URINE; VALIDATION STUDY; VOLUNTEER;

4-AMINOBENZOIC ACID; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FEMALE; GLUCURONIDASE; HUMANS; HYDROLYSIS; MALE; METABOLOME; METABOLOMICS; SKIN ABSORPTION; SOLID PHASE EXTRACTION; SONICATION; SULFATASES; SUNSCREENING AGENTS; TANDEM MASS SPECTROMETRY;

EID: 79955118178     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.03.045     Document Type: Article

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