Long-term efficacy of serenoa repens treatment in patients with mild and moderate symptomatic benign prostatic hyperplasia

Urologia Internationalis

Volumn 86, Issue 3, 2011, Pages 284-289

  Sinescu, Ioanel ^a   Geavlete, Petrisor ^b   Multescu, Razvan ^b   Gangu, Constantin ^a   Miclea, Florin ^d   Coman, Ioan ^f   Ioiart, Ioan ^e   Ambert, Valentin ^c   Constantin, Traian ^c   Petrut, Bogdan ^g   Feciche, Bogdan ^f  

^a FUNDENI CLINICAL INSTITUTE   (Romania)

^b Department of Urology   (Romania)

^c Urology Clinical Hospital   (Romania)

^d Emergency Clinical Hospital   (Romania)

^e VASILE GOLDIS WESTERN UNIVERSITY OF ARAD   (Romania)

^f University City Hospital   (Romania)

^g THE ONCOLOGY INSTITUTE PROF DR ION CHIRICUTA   (Romania)

Author keywords

Benign prostatic hyperplasia; Lower urinary tract symptoms; Phytotherapy; Serenoa repens

Indexed keywords

ALCOHOL; PROSTAMOL UNO; PROSTATE SPECIFIC ANTIGEN; SABAL EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; HUMAN; INTERNATIONAL PROSTATE SYMPTOM SCORE; LONG TERM CARE; LOWER URINARY TRACT SYMPTOM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; QUALITY OF LIFE; SCORING SYSTEM; SEXUAL FUNCTION; URINE FLOW RATE; URINE VOLUME;

ETHANOL; HUMANS; MALE; MODELS, STATISTICAL; PENILE ERECTION; PHYTOTHERAPY; PLANT EXTRACTS; PROSTATE; PROSTATIC HYPERPLASIA; QUALITY OF LIFE; SERENOA; TIME FACTORS; TREATMENT OUTCOME; URINARY TRACT; URINATION;

EID: 79955104986     PISSN: 00421138     EISSN: None     Source Type: Journal    
DOI: 10.1159/000322645     Document Type: Article

References (24)

1. Andersen JT, Nickel JC, Marshall VR, Schulman CC, Boyle P: Finasteride significantly reduces acute urinary retention and need for surgery in patients with symptomatic benign prostatic hyperplasia. Urology 1997; 49: 839-845. (Pubitemid 27246950)
2. Debruyne F, Boyle P, Calais Da Silva F, Gillenwater JG, Hamdy FC, Perrin P, Teillac P, Vela-Navarrete R, Raynaud JP, Schulman CC: Evaluation of the clinical benefit of permixon and tamsulosin in severe BPH patients - PERMAL study subset analysis. Eur Urol 2004; 45: 773-779.
3. Carraro JC, Raynaud JP, Koch G, Chisholm GD, Di Silverio F, Teillac P, Da Silva FC, Cauquil J, Chopin DK, Hamdy FC, Hanus M, Hauri D, Kalinteris A, Marencak J, Perier A, Perrin P: Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996; 29: 231-240, discussion 241-242. (Pubitemid 26365288)
4. Gerber GS, Kuznetsov D, Johnson BC, Burstein JD: Randomized, double-blind, placebo- controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology 2001; 58: 960-964, discussion 964-965.
5. Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, Santos PB, Stonebrook KA, deKernion JB: Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000; 163: 1451-1456. (Pubitemid 30226294)
6. Bauer HW, Casarosa C, Cosci M, Fratta M, Blessmann G: Saw palmetto fruit extract for treatment of benign prostatic hyperplasia. Results of a placebo-controlled double-blind study (in German). MMW Fortschr Med 1999; 141: 62. (Pubitemid 29323118)
7. Giannakopoulos X, Baltogiannis D, Giannakis D, Tasos A, Sofikitis N, Charalabopoulos K, Evangelou A: The lipidosterolic extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a comparison of two dosage regimens. Adv Ther 2002; 19: 285-296. (Pubitemid 36249776)
8. Tacklind J, MacDonald R, Rutks I, Wilt TJ: Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev 2009; 15:CD001423.
9. Willetts KE, Clements MS, Champion S, Ehsman S, Eden JA: Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial. BJU Int 2003; 92: 267-270. (Pubitemid 36966591)
10. Descotes JL, Rambeaud JJ, Deschaseau P, et al: Placebo-controlled evaluation of the efficacy and tolerability of Permixon in benign prostatic hyperplasia after exclusion of placebo responders. Clin Drug Invest 1995; 9: 291-297.
11. Gerber GS, Zagaja GP, Bales GT, Chodak GW, Contreras BA: Saw palmetto (Serenoa repens) in men with lower urinary tract symptoms: effects on urodynamic parameters and voiding symptoms. Urology 1998; 51: 1003-1007. (Pubitemid 28240862)
12. Pytel YA, Vinarov A, Lopatkin N, Sivkov A, Gorilovsky L, Raynaud JP: Long-term clinical and biologic effects of the lipidosterolic extract of Serenoa repens in patients with symptomatic benign prostatic hyperplasia. Adv Ther 2002; 19: 297-306. (Pubitemid 36249777)
13. Gerber GS, Kuznetsov D, Johnson BC, Burstein JD: Randomized, double-blind, placebo- controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology 2001; 58: 960-964.
14. Habib FK, Wyllie MG. Not all brands are created equal: a comparison of selected components of different brands of Serenoa repens extract. Prostate Cancer Prostatic Dis 2004; 7: 195-200. (Pubitemid 41741502)
15. Scaglione F, Lucini V, Pannacci M, Caronno A, Leone C: Comparison of the potency of different brands of Serenoa repens extract on 5alpha-reductase types I and II in prostatic co-cultured epithelial and fibroblast cells. Pharmacology 2008; 82: 270-275.
16. Breza J, Kliment J, Valansky L, Capova G: Phytotherapy of symptomatic benign prostatic hyperplasia using alcohol extract of Serenoa repens fruit (Prostamol Uno). Urologia 2005;11: 6-10.
17. Alyaev YG, Apolikhin OI, Mazo EB, Vinarov AZ, Lokshin KL, Medvedev AA, Permyakova OV, Spivak LG, Shkol'nikov ME: First results of a clinical trial of the efficacy and safety of Prostamolh Uno in patients with the early signs of prostatic hyperplasia. Eff Pharmacother Urol 2007;11:8-11.
18. Vinarov AZ, Aliaev IuG, Lokshin KL: Safety of continuous (more than 1 year) intake of Serenoa repens extract by patients with prostatic adenoma (in Russian). Urologiia 2009; 1: 84, 86-87.
19. Agbabiaka TB, Pittler MH, Wider B, Ernst E: Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009; 32: 637-647.
20. Avins AL, Bent S, Staccone S, Badua E, Padula A, Goldberg H, Neuhaus J, Hudes E, Shinohara K, Kane C: A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008; 16: 147-154.
21. Giuliano F: Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU Int 2006; 97(suppl 2):34-38, discussion 44-45. (Pubitemid 43356994)
22. Zlotta AR, Teillac P, Raynaud JP, Schulman CC: Evaluation of male sexual function in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) treated with a phytotherapeutic agent (Permixon), Tamsulosin or Finasteride. Eur Urol 2005; 48: 269-276. (Pubitemid 40957102)
23. Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, Avins AL: Saw palmetto for benign prostatic hyperplasia. N Engl J Med 2006; 354: 557-566. (Pubitemid 43209103)
24. Hizli F, Uygur MC: A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia. Int Urol Nephrol 2007; 39: 879-886. (Pubitemid 47365400)