Uniformity of drug payload and its effect on stability of solid lipid nanoparticles containing an ester prodrug

ACS Nano

Volumn 5, Issue 1, 2011, Pages 209-216

  Kim, Jin Ki ^a   Howard, Melissa D ^b   Dziubla, Thomas D ^c   Rinehart, John J ^d   Jay, Michael ^e   Lu, Xiuling ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of Kentucky   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e USA and North Carolina State University   (United States)

Author keywords

Dexamethasone; Encapsulation; Gel filtration chromatography; Nanoparticle; Stability

Indexed keywords

BIOLOGICAL ENVIRONMENTS; CHEMOTHERAPEUTIC AGENTS; DEXAMETHASONES; DRUG DISTRIBUTION; DRUG ENCAPSULATION; DRUG ENCAPSULATION EFFICIENCY; ENGINEERING METHODS; GEL FILTRATION CHROMATOGRAPHY; HUMAN PLASMAS; HUMAN SERUM ALBUMINS; IN-VIVO; INTERSTITIAL FLUID PRESSURES; MATRIX; NANOCARRIERS; NANOTEMPLATES; PRODRUGS; PROTEIN ADSORPTION; SOLID LIPID NANOPARTICLES; TUMOR UPTAKE;

ADSORPTION; CHROMATOGRAPHY; DRUG PRODUCTS; ENCAPSULATION; ESTERIFICATION; ESTERS; FILTRATION; GEL PERMEATION CHROMATOGRAPHY; GELS; PARTICLE SIZE ANALYSIS; SIZE DISTRIBUTION; SURFACE PROPERTIES; TUMORS;

NANOPARTICLES;

CARBON; DEXAMETHASONE; DRUG CARRIER; ESTER; FATTY ALCOHOL; LIPID; NANOPARTICLE; OCTADECANOL; PRODRUG; SERUM ALBUMIN; TRITIUM;

ARTICLE; BLOOD; CHEMISTRY; DRUG STABILITY; GEL CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM;

CARBON ISOTOPES; CHROMATOGRAPHY, GEL; DEXAMETHASONE; DRUG CARRIERS; DRUG STABILITY; ESTERS; FATTY ALCOHOLS; HUMANS; LIPIDS; NANOPARTICLES; PRODRUGS; SERUM ALBUMIN; TRITIUM;

EID: 79955089199     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn102357y     Document Type: Article

References (23)

1. Meng, H.; Liong, M.; Xia, T.; Li, Z.; Ji, Z.; Zink, J. I.; Nel, A. E. Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line. ACS Nano 2010, 4, 4539-4550.
2. Tang, Y.; Lei, T.; Manchanda, R.; Nagesetti, A.; Fernandez-Fernandez, A.; Srinivasan, S.; McGoron, A. J. Simultaneous Delivery of Chemotherapeutic and Thermal-Optical Agents to Cancer Cells by a Polymeric (PLGA) Nanocarrier: An In Vitro Study. Pharm. Res. 2010, 27, 2242-2253.
3. Heidel, J. D.; Davis, M. E. Clinical Developments in Nanotechnology for Cancer Therapy. Pharm. Res. 2010, DOI 10.1007/s11095-010-0178-7.
4. Gil, P. R.; Parak, W. J. Composite Nanoparticles Take Aim at Cancer. ACS Nano 2008, 2, 2200-2205.
5. Li, S. D.; Huang, L. Pharmacokinetics and Biodistribution of Nanoparticles. Mol. Pharm. 2008, 5, 496-504.
6. Farrell, D.; Ptak, K.; Panaro, N. J.; Grodzinski, P. Nanotechnology-Based Cancer Therapeutics-Promise and Challenge-Lessons Learned Through the NCI Alliance for Nanotechnology in Cancer. Pharm. Res. 2010, DOI 10.1007/s11095-010-0214-7
7. Brown, S. C.; Palazuelos, M.; Sharma, P.; Powers, K. W.; Roberts, S. M.; Grobmyer, S. R.; Moudgil, B. M. Nanoparticle Characterization for Cancer Nanotechnology and Other Biological Applications. Methods Mol. Biol. 2010, 624, 39-65.
8. Hall, J. B.; Dobrovolskaia, M. A.; Patri, A. K.; McNeil, S. E. Characterization of Nanoparticles for Therapeutics. Nanomedicine (London, U.K.) 2007, 2, 789-803.
9. Lu, X.; Howard, M. D.; Mazik, M.; Eldridge, J.; Rinehart, J. J.; Jay, M.; Leggas, M. Nanoparticles Containing Anti-Inflammatory Agents as Chemotherapy Adjuvants: Optimization and Characterization. AAPS J. 2008, 10, 133-140.
10. Lu, X.; Howard, M. D.; Talbert, D. R.; Rinehart, J. J.; Jay, M.; Leggas, M. Nanoparticles Containing Anti-Inflammatory Agents as Chemotherapy Adjuvants II: Role of Plasma Esterases in Drug Release. AAPS J. 2009, 11, 120-122.
11. Wang, H.; Li, M.; Rinehart, J. J.; Zhang, R. Pretreatment with Dexamethasone Increases Antitumor Activity of Carboplatin and Gemcitabine in Mice Bearing Human Cancer Xenografts: In Vivo Activity, Pharmacokinetics, and Clinical Implications for Cancer Chemotherapy. Clin. Cancer Res. 2004, 10, 1633-1644. (Pubitemid 38435553)
12. Wang, H.; Li, M.; Rinehart, J. J.; Zhang, R. Dexamethasone as a Chemoprotectant in Cancer Chemotherapy: Hematoprotective Effects and Altered Pharmacokinetics and Tissue Distribution of Carboplatin and Gemcitabine. Cancer Chemother. Pharmacol. 2004, 53, 459-467. (Pubitemid 38680242)
13. Leggas, M.; Kuo, K. L.; Robert, F.; Cloud, G.; Deshazo, M.; Zhang, R.; Li, M.; Wang, H.; Davidson, S.; Rinehart, J. Intensive Anti-Inflammatory Therapy with Dexamethasone in Patients with Non-Small Cell Lung Cancer: Effect on Chemotherapy Toxicity and Efficacy. Cancer Chemother. Pharmacol. 2009, 63, 731-743.
14. Maeda, H. Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects. Bioconjugate Chem. 2010, 21, 797-802.
15. Torchilin, V. P. Passive and Active Drug Targeting: Drug Delivery to Tumors as an Example. Handb. Exp. Pharmacol. 2010, 197, 3-53.
16. Susan, L. P.; Roth, R. B.; Adkins, W. C. Regression of Prostatic Cancer Metastasis by High Doses of Diethylstilbestrol Diphosphate. Urology 1976, 7, 598-601.
17. Liederer, B. M.; Borchardt, R. T. Enzymes Involved in the Bioconversion of Ester-Based Prodrugs. J. Pharm. Sci. 2006, 95, 1177-1195. (Pubitemid 43874435)
18. Oyewumi, M. O.; Yokel, R. A.; Jay, M.; Coakley, T.; Mumper, R. J. Comparison of Cell Uptake, Biodistribution and Tumor Retention of Folate-Coated and PEG-Coated Gadolinium Nanoparticles in Tumor-Bearing Mice. J. Controlled Release 2004, 95, 613-626. (Pubitemid 38340510)
19. Brissova, M.; Petro, M.; Lacik, I.; Powers, A. C.; Wang, T. Evaluation of Microcapsule Permeability via Inverse Size Exclusion Chromatography. Anal. Biochem. 1996, 242, 104-111. (Pubitemid 26378522)
20. Mori, S. Secondary Effects in Aqueous Size Exclusion Chromatography of Sodium Poly(styrenesulfonate) Compounds. Anal. Chem. 1989, 61, 530-534.
21. Haumaier, L.; Zech, W.; Franke, G. Gel Permeation Chromatography of Water-Soluble Organic Matter with Deionized Water as Eluent-I. Examination of the Method. Org. Geochem. 1990, 15, 413-417. (Pubitemid 20736421)
22. Aggarwal, P.; Hall, J. B.; McLeland, C. B.; Dobrovolskaia, M. A.; McNeil, S. E. Nanoparticle Interaction with Plasma Proteins as It Relates to Particle Biodistribution, Biocompatibility and Therapeutic Efficacy. Adv. Drug Delivery Rev. 2009, 61, 428-437.
23. Owens, D. E.; Peppas, N. A. Opsonization, Biodistribution, and Pharmacokinetics of Polymeric Nanoparticles. Int. J. Pharm. 2006, 307, 93-102. (Pubitemid 41773257)