Complications of methylene blue dye in breast surgery: Case reports and review of the literature

Journal of Cancer

Volumn 2, Issue 1, 2011, Pages 20-25

  Reyes, F J ^a   Noelck, M B ^b   Valentino, C ^b   Grasso LeBeau, L ^b   Lang, J E ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Adverse reactions; Blue dye; Breast; Complications; Methylene blue; Sentinel node; Surgery

Indexed keywords

ANTIBIOTIC AGENT; METHYLENE BLUE;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CONTAMINATION; BACTERIUM CULTURE; BREAST NECROSIS; BREAST REDUCTION; CANCER LOCALIZATION; CANCER SURGERY; CASE REPORT; DEBRIDEMENT; DISEASE SEVERITY; FEMALE; GRANULOMA; HUMAN; INJECTION; INTRADUCTAL CARCINOMA; MAMMOGRAPHY; MASTITIS; MEDICAL HISTORY; MYCOPLASMA; MYCOPLASMOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTOPERATIVE COMPLICATION; SEGMENTAL MASTECTOMY; SENTINEL LYMPH NODE BIOPSY; SKIN; SKIN INCISION; SKIN NECROSIS; SURGEON; SURGICAL RISK; TUMOR VOLUME; VACUUM ASSISTED CLOSURE;

EID: 79955074575     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.2.20     Document Type: Article

References (31)

1. Varghese P, Abdel-Rahman AT, Akberali S, Mostafa A, Gattuso JM, Carpenter R. Methylene blue dye--a safe and effective alternative for sentinel lymph node localization. Breast J. 2008;14(1):61-7.
2. Mathelin C, Croce S, Brasse D, Gairard B, Gharbi M, Andriamisandratsoa N, et al. Methylene blue dye, an accurate dye for sentinel lymph node identification in early breast cancer. Anticancer Res. 2009 Oct;29(10):4119-25.
3. Soni M, Saha S, Korant A, Fritz P, Chakravarty B, Sirop S, et al. A prospective trial comparing 1% lymphazurin vs 1% methylene blue in sentinel lymph node mapping of gastrointestinal tumors. Ann Surg Oncol. 2009 Aug;16(8):2224-30.
4. Zakaria S, Hoskin TL, Degnim AC. Safety and technical success of methylene blue dye for lymphatic mapping in breast cancer. Am J Surg. 2008 Aug;196(2):228-33.
5. Stradling B, Aranha G, Gabram S. Adverse skin lesions after methylene blue injections for sentinel lymph node localization. Am J Surg. 2002 Oct;184(4):350-2.
6. Salhab M, Al Sarakbi W, Mokbel K. Skin and fat necrosis of the breast following methylene blue dye injection for sentinel node biopsy in a patient with breast cancer. Int Semin Surg Oncol. 2005 Nov 28;2:26.
7. Lyman GH, Giuliano AE, Somerfield MR, Benson AB3rd, Bodurka DC, Burstein HJ, et al. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol. 2005;23(30):7703-20.
8. Thevarajah S, Huston TL, Simmons RM. A comparison of the adverse reactions associated with isosulfan blue versus methylene blue dye in sentinel lymph node biopsy for breast cancer. Am J Surg. 2005 Feb;189(2):236-9.
9. Stoeckel WT, David L, Levine EA, Argenta AE, Perrier ND. Vacuum-assisted closure for the treatment of complex breast wounds. Breast. 2006 Oct;15(5):610-3.
10. Leininger BE, Rasmussen TE, Smith DL, Jenkins DH, Coppola C. Experience with wound VAC and delayed primary closure of contaminated soft tissue injuries in Iraq. J Trauma. 2006 Nov;61(5):1207-11.
11. Centers for Disease Control and Prevention (CDC). Mycobacterium chelonae infections associated with face lifts--New Jersey, 2002-2003. MMWR Morb Mortal Wkly Rep. 2004;53(9):192-4.
12. Govaert GA, Oostenbroek RJ, Plaisier PW. Prolonged skin staining after intradermal use of patent blue in sentinel lymph node biopsy for breast cancer. Eur J Surg Oncol. 2005 May;31(4):373-5.
13. Komenaka GS, Bouton M. Prolonged Injection Site Mass Can Occur with Methylene Blue but Not Lymphazurin Blue After the Sentinel Node Procedure; Thirty-Second Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 10-13, 2009. San Antonio, TX: American Association for Cancer Research. 2009.
14. Singh-Ranger G, Mokbel K. Capsular contraction following immediate reconstructive surgery for breast cancer - An association with methylene blue dye. Int Semin Surg Oncol. 2004 May 11;1(1):3.
15. Roisman I, Barak V, Manny J, Libson E, Wygoda M, Neuman A, et al. Fat necrosis below musculocutaneous flap mimicking carcinoma of breast. Ann Plast Surg. 1991 May;26(5):479-82.
16. Giuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg. 1994;220(3):391-8.
17. Veronesi U, Paganelli G, Galimberti V, Viale G, Zurrida S, Bedoni M, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet. 1997;349(9069):1864-7.
18. Rubio IT, Klimberg VS. Techniques of sentinel lymph node biopsy. Semin Surg Oncol. 2001;20(3):214-23.
19. Layeeque R, Henry-Tillman R, Korourian S, Kass R, Klimberg VS. Subareolar sentinel node biopsy for multiple breast cancers. Am J Surg. 2003;186(6):730-5.
20. Kern KA. Sentinel lymph node mapping in breast cancer using subareolar injection of blue dye. J Am Coll Surg. 1999;189(6):539-45.
21. Kern KA. Concordance and validation study of sentinel lymph node biopsy for breast cancer using subareolar injection of blue dye and technetium 99m sulfur colloid. J Am Coll Surg. 2002;195(4):467-75.
22. Klimberg VS, Rubio IT, Henry R, Cowan C, Colvert M, Korourian S. Subareolar versus peritumoral injection for location of the sentinel lymph node. Ann Surg. 1999;229(6):860-4.
23. Rodier JF, Velten M, Wilt M, Martel P, Ferron G, Vaini-Elies V, et al. Prospective multicentric randomized study comparing periareolar and peritumoral injection of radiotracer and blue dye for the detection of sentinel lymph node in breast sparing procedures: FRANSENODE trial. J Clin Oncol. 2007 Aug 20;25(24):3664-9.
24. Samphao S, Eremin JM, El-Sheemy M, Eremin O. Management of the axilla in women with breast cancer: current clinical practice and a new selective targeted approach. Ann Surg Oncol. 2008 May;15(5):1282-96.
25. Newman EA, Newman LA. Lymphatic mapping techniques and sentinel lymph node biopsy in breast cancer. Surg Clin North Am. 2007;87(2):353-64.
26. Blessing WD, Stolier AJ, Teng SC, Bolton JS, Fuhrman GM. A comparison of methylene blue and lymphazurin in breast cancer sentinel node mapping. Am J Surg. 2002 Oct;184(4):341-5.
27. Liu Y, Truini C, Ariyan S. A randomized study comparing the effectiveness of methylene blue dye with lymphazurin blue dye in sentinel lymph node biopsy for the treatment of cutaneous melanoma. Ann Surg Oncol. 2008 Sep;15(9):2412-7.
28. Simmons R, Thevarajah S, Brennan MB, Christos P, Osborne M. Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization. Ann Surg Oncol. 2003 Apr;10(3):242-7.
29. Sandhu S, Farag E, Argalious M. Anaphylaxis to isosulfan blue dye during sentinel lymph node biopsy. J Clin Anesth. 2005 Dec;17(8):633-5.
30. Raut CP, Hunt KK, Akins JS, Daley MD, Ross MI, Singletary SE, et al. Incidence of anaphylactoid reactions to isosulfan blue dye during breast carcinoma lymphatic mapping in patients treated with preoperative prophylaxis: results of a surgical prospective clinical practice protocol. Cancer. 2005 Aug 15;104(4):692-9.
31. Golshan M, Nakhlis F. Can methylene blue only be used in sentinel lymph node biopsy for breast cancer? Breast J. 2006;12(5):428-30.