Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression

Pharmaceutical Biology

Volumn 49, Issue 5, 2011, Pages 477-483

  Chatterjee, Manavi ^a   Verma, Pinki ^a   Maurya, Rakesh ^a   Palit, Gautam ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

elevated plus maze; forced swim test; holeboard test; light dark test; Mixed anxiety and depressive disorders; tail suspension test

Indexed keywords

DIAZEPAM; IMIPRAMINE; OCIMUM SANCTUM EXTRACT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; LOCOMOTION; LOW DRUG DOSE; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; STEREOTYPY; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; DEPRESSION; DISEASE MODELS, ANIMAL; HINDLIMB SUSPENSION; MALE; MAZE LEARNING; MICE; MOTOR ACTIVITY; OCIMUM; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; SWIMMING;

ANIMALIA; LAMIACEAE; MUS; OCIMUM TENUIFLORUM;

EID: 79955063689     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2010.523832     Document Type: Article

References (35)

1. Adzu B, Amos S, Muazzam I, Inyang US, Gamaniel KS. (2002). Neuropharmacological screening of Diospyros mespiliformis in mice. J Ethnopharmacol 83:139-143. (Pubitemid 36164738)
2. Asha MK, Prashanth D, Murali B, Padmaja R, Amit A. (2001). Anthelmintic activity of essential oil of Ocimum sanctum and eugenol. Fitoterapia 72:669-670. (Pubitemid 32799269)
3. Baldessarini RJ. (2006). Drug therapy of depression and anxiety disorders. In: Brunton LL, Lazo JS, Parker KL, eds. Goodmann and Gillmann's the Pharmacological Basis of Therapeutics. New York: McGraw-Hill, pp. 429-459.
4. Barkow K, Heun R, Wittchen HU, Bedirhan Ustün T, Gänsicke M, Maier W. (2004). Mixed anxiety-depression in a 1 year follow-up study: Shift to other diagnoses or remission? J Affect Disord 79:235-239. (Pubitemid 38340549)
5. Bhattacharyya D, Sur TK, Jana U, Debnath PK. (2008). Controlled programmed trial of Ocimum sanctum leaf on generalized anxiety disorders. Nepal Med Coll J 10:176-179.
6. Chatterjee M, Verma P, Palit G. (2010). Comparative evaluation of Bacopa monnera and Panax ginseng in experimental anxiety and depressive models in mice. Indian J Exp Biol 48:306-313.
7. Crawley J, Goodwin FK. (1980). Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol Biochem Behav 13:167-170. (Pubitemid 11225713)
8. Dharmani P, Kuchibhotla VK, Maurya R, Srivastava S, Sharma S, Palit G. (2004). Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn. J Ethnopharmacol 93: 197-206. (Pubitemid 38962405)
9. Dunham NW, Miya TS. (1957). A note on a simple apparatus for detecting neurological deficit in rats and mice. J Am Pharm Assoc Am Pharm Assoc (Baltim) 46:208-209.
10. Geetha RK, Vasudevan DM. (2004). Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: in vivo and in vitro studies. Life Sci 76:21-28. (Pubitemid 39389168)
11. Godhwani S, Godhwani JL, Vyas DS. (1987). Ocimum sanctum: an experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. J Ethnopharmacol 21:153-163.
12. Gupta P, Yadav DK, Siripurapu KB, Palit G, Maurya R. (2007). Constituents of Ocimum sanctum with antistress activity. J Nat Prod 70:1410-1416. (Pubitemid 47584579)
13. Gupta S, Mediratta PK, Singh S, Sharma KK, Shukla R. (2006). Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil. Indian J Exp Biol 44:300-304.
14. Haefely W. (1992). The role of GABA in anxiolytic/antidepressant drug action. In: Elliott JM, Heal DJ, Marsden CA, eds. Experimental Approaches to Anxiety and Depression. Chichester: John Wiley, pp. 151-168.
15. Hogg S. (1996). A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol Biochem Behav 54:21-30. (Pubitemid 26146661)
16. Karthikeyan K, Gunasekaran P, Ramamurthy N, Govindasamy S. (1999). Anticancer activity of Ocimum sanctum. Pharm Biol 37:285-290. (Pubitemid 30035143)
17. Labrid C, Mocaër E, Kamoun A. (1992). Neurochemical and pharmacological properties of tianeptine, a novel antidepressant. Br J Psychiatry 160:56-60.
18. Lister RG. (1987). The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl) 92:180-185. (Pubitemid 17072893)
19. Moreira EG, Nascimento N, Rogero JR, Vassilieff VS. (2000). Gabaergicbenzodiazepine system is involved in the crotoxin-induced anxiogenic effect. Pharmacol Biochem Behav 65:7-13. (Pubitemid 30017987)
20. Murphy DL, Mitchell PB, Potter WZ. (1995). Novel pharmacological approaches to the treatment of depression. In: Bloom FE, Kupfer DJ, eds. Psychopharmacology: Fourth Generation of Progress. New York: Raven Press, pp. 1143-1153.
21. Porsolt RD, Le Pichon M, Jalfre M. (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732. (Pubitemid 8073804)
22. Reus VI. (2008). Mental disorders. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine. New York: McGraw-Hill, pp. 2710-2723.
23. Samson J, Sheela Devi R, Ravindran R, Senthilvelan M. (2006). Biogenic amine changes in brain regions and attenuating action of Ocimum sanctum in noise exposure. Pharmacol Biochem Behav 83:67-75.
24. Sanberg PR, Zoloty SA, Willis R, Ticarich CD, Rhoads K, Nagy RP, Mitchell SG, Laforest AR, Jenks JA, Harkabus LJ. (1987). Digiscan activity: automated measurement of thigmotactic and stereotypic behavior in rats. Pharmacol Biochem Behav 27:569-572. (Pubitemid 17107033)
25. Shader RI, Greenblatt DJ. (1995). Pharmacotherapy of acute anxiety. In: Bloom FE, Kupfer DJ, eds. Psychopharmacology: Fourth Generation of Progress. New York: Raven Press, pp. 1341-1348.
26. Singh S, Malhotra M, Majumdar DK. (2005). Antibacterial activity of Ocimum sanctum L. fixed oil. Indian J Exp Biol 43:835-837. (Pubitemid 41277289)
27. Steru L, Chermat R, Thierry B, Simon P. (1985). The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl) 85:367-370. (Pubitemid 15123115)
28. Takeda H, Tsuji M, Miyamoto J, Matsumiya T. (2002). Rosmarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress. Psychopharmacology (Berl) 164:233-235. (Pubitemid 36015589)
29. The World Health Report (WHO). (2001). Mental Health: New Understanding, New Hope. Geneva. Retrieved from http://www. who.int/whr/2001/en/whr01-en.pdf
30. Walter G, Rey JM. (1999). The relevance of herbal treatments for psychiatric practice. Aust NZ J Psychiatry 33:482-489; discussion 490-493. (Pubitemid 29386867)
31. Weissman MM, Markowitz JS, Ouellette R, Greenwald S, Kahn JP. (1990). Panic disorder and cardiovascular/cerebrovascular problems: Results from a community survey. Am J Psychiatry 147:1504-1508. (Pubitemid 20365441)
32. Willner P, Muscat R. (1991). Animal models for investigating the symptoms of depression and the mechanisms of action of antidepressant drugs. In: Oliver B, Mos J, Slagen J, eds. Animal Models in Psychopharmacology: Advances in Pharmacology Sciences. Birkhäuser Verlag Basel, pp. 183-198.
33. Yocca FD. (1990). Neurochemistry and neurophysiology of buspirone and gepirone: Interactions at presynaptic and postsynaptic 5-HT1A receptors. J Clin Psychopharmacol 10:6S-12S. (Pubitemid 20212923)
34. Young R, Johnson DN. (1991). A fully automated light/dark apparatus useful for comparing anxiolytic agents. Pharmacol Biochem Behav 40:739-743.
35. Zhang ZJ. (2004). Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sci 75:1659-1699.