Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 300, Issue 3, 2011, Pages

  Hicks, Caitlin W ^a,b,c   Li, Yan ^a   Okugawa, Shu ^d   Solomon, Steven B ^a   Moayeri, Mahtab ^d   Leppla, Stephen H ^d   Mohanty, Ajana ^a   Subramanian, G Mani ^e   Mignone, Thi S ^e   Fitz, Yvonne ^a   Cui, Xizhong ^a   Eichacker, Peter Q ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Heart function

Indexed keywords

ADEFOVIR; ADENYLATE CYCLASE; ANTHRAX EDEMA TOXIN; ANTHRAX TOXIN; CYCLIC AMP; DOBUTAMINE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DEPRESSION; EFFLUENT; HEART AFTERLOAD; HEART EJECTION FRACTION; HEART FUNCTION; HEART MUSCLE; HEART PERFUSION; HEART PRELOAD; HEART RATE; HEART VENTRICLE PRESSURE; IN VIVO STUDY; INOTROPISM; ISOLATED HEART; MALE; MASKING; NONHUMAN; PRIORITY JOURNAL; RAT; SHOCK; TACHYCARDIA; VASODILATATION;

ADENINE; ADRENERGIC BETA-1 RECEPTOR AGONISTS; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CYCLIC AMP; DOBUTAMINE; HEART; HEART RATE; MALE; MYOCARDIUM; PHOSPHONIC ACIDS; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; VASODILATION; VASODILATOR AGENTS;

EID: 79955058509     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01128.2010     Document Type: Article

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