Expression of the stem cell marker, nanog, in human endometrial adenocarcinoma

International Journal of Gynecological Pathology

Volumn 30, Issue 3, 2011, Pages 262-270

  Zhou, Xi ^a   Zhou, Yu Ping ^a   Huang, Guang Rong ^a   Gong, Bao Lan ^a   Yang, Bo ^a   Zhang, Dong Xia ^a   Hu, Pin ^a   Xu, Sheng Rong ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Cancer stem cell; Endometrial adenocarcinoma; Endometrium; Nanog; Tumorosphere

Indexed keywords

MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOMETRIUM; ENDOMETRIUM CANCER; ENDOMETRIUM CARCINOMA; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CELL SEPARATION; ENDOMETRIAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; NEOPLASTIC STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TISSUE ARRAY ANALYSIS; TRANSPLANTATION, HETEROLOGOUS; TUMOR MARKERS, BIOLOGICAL;

EID: 79955053607     PISSN: 02771691     EISSN: 15387151     Source Type: Journal    
DOI: 10.1097/PGP.0b013e3182055a1f     Document Type: Article

References (19)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin 2008;58:71-96. (Pubitemid 351521864)
2. Wang Y, Xue F, Broaddus RR, et al. Clinicopathological features in endometrial carcinoma associated with Lynch syndrome in China. Int J Gynecol Cancer 2009;19: 651-6.
3. Ebben JD, Treisman DM, Zorniak M, et al. The cancer stem cell paradigm: a new understanding of tumor development and treatment. Expert Opin Ther Targets 2010;14:621-32.
4. Gargett CE, Schwab KE, Zillwood RM, et al. Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium. Biol Reprod 2009;80: 1136-45.
5. Hubbard S, Gargett C. A cancer stem cell origin for human endometrial carcinoma? Reproduction 2010;140:23-32.
6. Gorai I, Yanagibashi T, Taki A, et al. Uterine carcinosarcoma is derived from a single stem cell: an in vitro study. Int J Cancer 1998;72:821-7. (Pubitemid 27431526)
7. Okumura-Nakanishi S, Saito M, Niwa H, et al. Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem 2005;280:5307-17. (Pubitemid 40280004)
8. Boer B, Kopp J, Mallanna S, et al. Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. Nucleic Acids Res 2007;35:1773-86. (Pubitemid 47061649)
9. Seigel G, Hackam A, Ganguly A, et al. Human embryonic and neuronal stem cell markers in retinoblastoma. Mol Vis 2007; 13:823-32. (Pubitemid 46908324)
10. Bae KM, Su Z, Frye C, et al. Expression of pluripotent stem cell reprogramming factors by prostate tumor initiating cells. J Urol 2010;183:2045-53.
11. Boer B, Cox J, Claassen D, et al. Regulation of the Nanog gene by both positive and negative cis-regulatory elements in embryonal carcinoma cells and embryonic stem cells. Mol Reprod Dev 2009;76:173-82.
12. Santagata S, Ligon KL, Hornick JL. Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors. Am J Surg Pathol 2007;31: 836-45. (Pubitemid 47165136)
13. Bapat S, Mali A, Koppikar C, et al. Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer. Cancer Res 2005;65:3025-9. (Pubitemid 40524578)
14. Hubbard SA, Friel AM, Kumar B, et al. Evidence for cancer stem cells in human endometrial carcinoma. Cancer Res 2009; 69:8241-8.
15. Piestun D, Kochupurakkal BS, Jacob-Hirsch J, et al. Nanog transforms NIH3T3 cells and targets cell-type restricted genes. Biochem Biophys Res Commun 2006;343:279-85.
16. Morrison S, Shah N, Anderson D. Regulatory mechanisms review in stem cell biology. Cell 1997;88:287-98. (Pubitemid 27131370)
17. Alberio R, Campbell K, Johnson A. Reprogramming somatic cells into stem cells. Reproduction 2006;132:709-20. (Pubitemid 44782521)
18. Ezeh U, Turek P, Reijo R, et al. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Genesis 2005; 104:2255-65. (Pubitemid 41579973)
19. Zhang J, Wang X, Chen B, et al. Expression of Nanog gene promotes NIH3T3 cell proliferation. Biochem Biophys Res Commun 2005;338:1098-102. (Pubitemid 41597751)