Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features

American Journal of Clinical Pathology

Volumn 135, Issue 5, 2011, Pages 686-696

  Huh, Yang O ^a   Schweighofer, Carmen D ^a   Ketterling, Rhett P ^b   Knudson, Ryan A ^b   Vega, Francisco ^a   Kim, Ji E ^a   Luthra, Rajyalakshmi ^a   Keating, Michael J ^a   Medeiros, L Jeffrey ^a   Abruzzo, Lynne V ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Atypical morphology; BCL3; Chronic lymphocytic leukemia; IGHV somatic mutation; t(14; 19)(q32; q13)

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 13Q; CHROMOSOME 14; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; HUMAN; IMMUNOPHENOTYPING; KARYOTYPE; LYMPHADENOPATHY; LYMPHOCYTOMA; MALE; MOLECULAR GENETICS; PRIORITY JOURNAL; TRISOMY 12;

ADULT; AGED; AGED, 80 AND OVER; B-LYMPHOCYTES; BONE MARROW; CELL SIZE; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; HUMANS; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTOSIS; MALE; MIDDLE AGED; MUTATION; NEOPLASTIC STEM CELLS; ONCOGENE PROTEINS, FUSION; TRANSLOCATION, GENETIC; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 79955046604     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPOEFP3SLX6HXJ     Document Type: Article

References (33)

1. Michaux L, Dierlamm J, Wlodarska I, et al. t (14;19)/BCL3 rearrangements in lymphoproliferative disorders: a review of 23 cases. Cancer Genet Cytogenet. 1997;94:36-43. (Pubitemid 27133499)
2. Bloomfield CD, Arthur DC, Frizzera G, et al. Nonrandom chromosome abnormalities in lymphoma. Cancer Res. 1983;43:2975-2984. (Pubitemid 13100576)
3. Au WY, Horsman DE, Ohno H, et al. Bcl-3/IgH translocation (14;19) (q32;q13) in non-Hodgkin's lymphomas. Leuk Lymphoma. 2002;43:813-816. (Pubitemid 34428668)
4. Soma LA, Gollin SM, Remstein ED, et al. Splenic small B-cell lymphoma with IGH/BCL3 translocation. Hum Pathol. 2006;37:218-230. (Pubitemid 43099843)
5. Huh YO, Abruzzo LV, Rassidakis GZ, et al. The t (14;19) (q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases. Br J Haematol. 2007;136:220-228. (Pubitemid 46020749)
6. Huh YO, Keating MJ, Saffer HL, et al. Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. Am J Clin Pathol. 2001;116:437-443. (Pubitemid 32851978)
7. Matutes E, Owusu-Ankomah K, Morilla R, et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994;8:1640-1645. (Pubitemid 24323778)
8. Moreau EJ, Matutes E, A'Hern RP, et al. Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b). Am J Clin Pathol. 1997;108:378-382. (Pubitemid 27411287)
9. Kanungo A, Medeiros LJ, Abruzzo LV, et al. Lymphoid neoplasms associated with concurrent t (14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol. 2006;19:25-33. (Pubitemid 43250976)
10. Canoz O, Rassidakis GZ, Admirand JH, et al. Immunohistochemical detection of BCL-3 in lymphoid neoplasms: a survey of 353 cases. Mod Pathol. 2004;17:911-917. (Pubitemid 38993775)
11. Admirand JH, Rassidakis GZ, Abruzzo LV, et al. Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma. Mod Pathol. 2004;17:954-961. (Pubitemid 38993780)
12. Yin CC, Medeiros LJ, Cromwell CC, et al. Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma. Mod Pathol. 2007;20:1-7. (Pubitemid 44967943)
13. Brochet X, Lefranc MP, Giudicelli V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 2008;36: W503-W508.
14. Ghia P, Stamatopoulos K, Belessi C, et al. ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia [editorial]. Leukemia. 2007;21:1-3. (Pubitemid 44921826)
15. Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998;102:1515-1525. (Pubitemid 28492218)
16. Pardanani A, Ketterling RP, Brockman SR, et al. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood. 2003;102:3093-3096. (Pubitemid 37314742)
17. Sukov WR, Cheville JC, Carlson AW, et al. Utility of ALK-1 protein expression and ALK rearrangements in distinguishing inflammatory myofibroblastic tumor from malignant spindle cell lesions of the urinary bladder. Mod Pathol. 2007;20:592-603. (Pubitemid 46632001)
18. Martin-Subero JI, Ibbotson R, Klapper W, et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t (14;19) (q32;q13) or variant BCL3-translocation. Leukemia. 2007;21:1532-1544. (Pubitemid 46969871)
19. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910-1916. (Pubitemid 32064784)
20. Nicoloso MS, Kipps TJ, Croce CM, et al. MicroRNAs in the pathogeny of chronic lymphocytic leukaemia. Br J Haematol. 2007;139:709-716. (Pubitemid 350115732)
21. Reid A, Naresh K, Wagner S, et al. Interphase FISH using a BCL3 probe to diagnose the t (14;19) (q32;q13)-positive small B-cell leukemia. Leuk Lymphoma. 2008;49:356-358. (Pubitemid 351193933)
22. Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840-1847. (Pubitemid 29430399)
23. H genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854. (Pubitemid 29430400)
24. Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003;348:1764-1775. (Pubitemid 36514707)
25. H mutational status in B-cell chronic lymphocytic leukemia. Cytometry B Clin Cytom. 2007;72:96-102. (Pubitemid 46365538)
26. Rassenti LZ, Huynh L, Toy TL, et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med. 2004;351:893-901. (Pubitemid 39096916)
27. Admirand JH, Knoblock RJ, Coombes KR, et al. Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression [published online ahead of print July 23, 2010]. Mod Pathol. 2010;23:1518-1523. doi:10.1038/modpathol.2010. 131.
28. Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 2007;109:259-270. (Pubitemid 46070124)
29. Damle RN, Ghiotto F, Valetto A, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 2002;99:4087-4093. (Pubitemid 35332051)
30. Klein U, Tu Y, Stolovitzky GA, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194:1625-1638. (Pubitemid 33126813)
31. Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med. 2001;194:1639-1647. (Pubitemid 33126814)
32. Ghiotto F, Fais F, Valetto A, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest. 2004;113:1008-1016. (Pubitemid 38544122)
33. Schweighofer CD, Huh YO, Luthra R, et al. The B cell antigen receptor in atypical chronic lymphocytic leukemia with t (14;19) (q32;q13) demonstrates remarkable stereotypy. Int J Cancer. In press.