Adipogenic hotspots: Where the action is

EMBO Journal

Volumn 30, Issue 8, 2011, Pages 1418-1419

  Steger, David J ^a   Lazar, Mitchell A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; STAT5 PROTEIN;

ADIPOGENESIS; ARTICLE; CELL CULTURE; EPIGENETICS; GENOME ANALYSIS; HISTONE MODIFICATION; PRIORITY JOURNAL;

ADIPOGENESIS; ANIMALS; CHROMATIN ASSEMBLY AND DISASSEMBLY; HUMANS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 79955039896     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.80     Document Type: Article

References (10)

1. Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M (2005) Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122: 33-43 (Pubitemid 40977938)
2. Farmer SR (2006) Transcriptional control of adipocyte formation. Cell Metab 4: 263-273 (Pubitemid 44430910)
3. Gerstein MB, Lu ZJ, Van Nostrand EL, Cheng C, Arshinoff BI, Liu T, Yip KY, Robilotto R, Rechtsteiner A, Ikegami K, Alves P, Chateigner A, Perry M, Morris M, Auerbach RK, Feng X, Leng J, Vielle A, Niu W, Rhrissorrakrai K et al (2010) Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330: 1775-1787
4. Lefterova MI, Steger DJ, Zhuo D, Qatanani M, Mullican SE, Tuteja G, Manduchi E, Grant GR, Lazar MA (2010) Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Mol Cell Biol 30: 2078-2089
5. Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert Jr CJ, Liu XS, Lazar MA (2008) PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 22: 2941-2952
6. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED (2010) Comparative epigenomic analysis of murine and human adipogenesis. Cell 143: 156-169
7. modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD et al (2010) Identification of functional elements and regulatory circuits by Drosophila modENCODE, Science, 330, 1787-1797.
8. Nielsen R, Pedersen TA, Hagenbeek D, Moulos P, Siersbaek R, Megens E, Denissov S, Borgesen M, Francoijs KJ, Mandrup S, Stunnenberg HG (2008) Genome-wide profiling of PPARgamma: RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev 22: 2953-2967
9. Siersbaek R, Nielsen R, John S, Sung M-H, Baek S, Loft A, Hager GL, Mandrup S (2011) Extensive chromatin remodeling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J 30: 1459-1472
10. Steger DJ, Grant GR, Schupp M, Tomaru T, Lefterova MI, Schug J, Manduchi E, Stoeckert Jr CJ, Lazar MA (2010) Propagation of adipogenic signals through an epigenomic transition state. Genes Dev 24: 1035-1044