Immunologic self-tolerance Maintained by activated T cells expressing 11-2 receptor α-chains (CD25++)

Journal of Immunology

Volumn 186, Issue 7, 2011, Pages 3808-3821

  Sakaguchi, Shimon ^a,d   Sakaguchi, Noriko ^a   Asano, Masanao ^b   Itoh, Misako ^c   Toda, Masaaki ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c University of Tsukuba School of Medicine   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR ALPHA;

ADRENALITIS; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GASTRITIS; GLOMERULONEPHRITIS; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; INSULITIS; LYMPHOCYTE TRANSFER; MALE; MOUSE; NONHUMAN; OVARY INFLAMMATION; POLYARTHRITIS; PRIORITY JOURNAL; RISK FACTOR; SIALOADENITIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYROIDITIS; WASTING SYNDROME; ANIMAL; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CELL CULTURE; DISEASE MODEL; HISTORY; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NUDE MOUSE; PATHOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; SELF TOLERANCE;

EID: 79955038372     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Irvine, W., B. Clarke, L. Scharth, D. Cullcn. and L. Duncan. 1970. Thyroid and gastric autoimmimity in patients with diabetes mellitus. Lancet. ii:l63.
2. Riley, W. J., A. Winer, and D. Goldstein. 1983. Coincident presence of thyrogastric autoimmunity at onset of type 1 (insulin-dependent) diabetes. Diabetologia 24:418.
3. Ouiraby, F. W., C Jensen, D. Nawrocki, and P. Schollin. 1978, Selected autoimmune diseases in the dog. Vet. Chn. North Am. H;665.
4. Khoury, E. L,, G, F. Bottazzo, L. C. Pontes de Carvalho, G. Wick, and I. M. RoifS, 1982- Predisposition to organ-specific autoimrniiniiy in Obese strain (OS) chickens: Reactivity to thyroid, gastric, adrenal 24. and pancreatic cytoplasrnic antigens. Clin. Exp. Immunol. 49:273.
5. Sternthal, E., A. A. Like, K. Sarantis, and L. E. Braverrnan. 1981. lymphocytic thyroiditis and diabetes in the BB/W rat: A new model 25. of autoimmune endocrinopalhy. Diabetes 30:1058.
6. Elder, M. N. Maclaren, W. Riley, and T. McConnel. 1982. Gastric parietal cell and other autoantibodies in the BB rat. Diabetes 31:313.
7. Bernard. N. F., F. Ertug, and H. Margolese. 1992. High incidence of tlivroiditis and anti-thyroid autoantibodies in NOD mice. Diabetes 41:40.
8. Sakagucht, S., T. H. Ermak, M. Toda, I. J. Berg. W. Ho, B Fazekas de St. Groib. PA. Peterson, N. S.ikaguchi, and M. M. Dasis. 1994 Induction of autoimmune disease in mice by germlme alteration of the 1' cell receptor gene expression. J Immtanol. 152:1471.
9. Roitt, I. M. 1988. Essential Immunology, 6th Ed. Blackweil Scientific Publications Ltd., Oxford, pp. 238-273,
10. Andrews, B. A., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C, B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes: Clinical and inimunopathological manifestations in several strains. J. E.xp. Med. 148: 1198.
11. Gleichmann, E., S. T, Pals, A. G. Rolink, T. Radaszkiewkz, and H. Gleichmann, 1984. Graft-versus-host reactions: Clues to the etiopathology of a spectrum of immunologies! diseases. Immunol. Today 5:324.
12. Bias, W. B.. J. D. Reveille, T. H. Beaty, D. A. Meyers, and F. C Arnell. 1986. Evidence that autoimrnunity in man is a Mendelian dominant trait. Am, J. Hum. Genet. 39:584.
13. Thomas, D. J. B., A. Young, A. N. Gorsuch, G. F. Boitazzo, and A. G. Cudworth. 1983. Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease. Ann. Rheum. Dis. 42:297.
14. Miller, F. W., G. F. Moore, B. D. Weintraub, and A. D. Steinberg. 1987. Prevalence of thyroid disease and abnormal thyroid function test results in patients with systemic lupus erythematosus. Arthritis Rheum. 30:IS24.
15. Quimby, F. W., and R. S, Schwartz. 1982. Systemic lupus erythematosus in mice and dogs. In Clinical Aspects of Immunology, 4th Ed. P, J. Lachmann and D. K. Peters, eds. Blackweil Scientific Publications, Oxford, pp. 1217-1230.
16. Sakaguchi, S., and N. Sakaguchi. 1990. Thymus and autoimmunity: Capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease. J. Exp. Med. 172:537.
17. Like, A. A., A. A. Rossini, D. L. Guberski, M. C. Appel, and R. M. Williams. 1981. Spontaneous diabetes mellitus: Reversal and prevention in the BB/W rat with antiserum to rat Ivmphocyies, Science 206:1421,
18. Dc Calvalho. L. C, G. Wick, and I. M. Roitt. 1981. Requirement of T cells for the development of spontaneous autoimmune thyroiditis 37. in Obese strain (OS) chickens. ./. Immunol. 126:750.
19. Londei, M., G. F. Bottazo. and M Feldman. 1985. Human T ceil clones from autoimmune thyroid glands: Specific recognition of autologous thyroid cells. Science 228:85.
20. Shizuru, J. A.. C. Taylor-Edwards, B. A, Banks, A. K. Gregory, and C. G. Fathmaii. 1988. Immunotherapy of the nonobese diabetic mouse: Treatment with an antibody to T-hcIper lymphocytes. Science 240:659.
21. Wofsy, D,, and W. E. Seaman. 1985. Successful treatment of autoimmunity in NZB/NZW Fl mice with monoclonal antibody to L3T4, J. Exp. Med. 161:378.
22. Sakaguchi, S., K- Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T-cell subset. I. Evidence for the active participation of T cells in natural self-tolerance: Deficit of a T-cell subset as a possible cause of autoimmune disease, J. Exp, Med. 161:72.
23. bright normal T cells for the induction of thyroiditis. J. Immunol. 141:105.
24. Smith, H., Y.-H. Lou, P. Lacy, and K. S. K. Tung. 1992. Tolerance mechanism in experimental ovarian and gastric autoimmune disease. J. Immunol. 149:2212.
25. low subset. J. Exp Med. 172:1701.
26. McKeever. U., J. P. Mordes, D. L. Greiner, M. C. Appel, J. Rozing, E. S. Handler, and A. A. Rossini. 1990. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc. Natl. Acad. Sci. USA 87:7618.
27. Powrie, F., M. W, Leach, S. Mauze, L. Barcomb Caddie, and R. L. Coffman. 1993. Phenotypically distinct subsets of CD4 ' T cells induce or protect from chronic intestinal inflammation in C.B.-17 scid mice. Int. Immunol. 5:1461.
28. + T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice; disease development is prevented by cotransfer of purified CD4f T cells. J. Exp. Med, 178:327.
29. Ortega-R G., R. J. Robb, E. M. Shevach. and T. R, Malek. 1984, The murine 1L-2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. / Immunol. 133:1970.
30. Dialynas, D. P., Z. S. Ouan, K. A. Wall A. Pierres, J. Quintans, M. R. Loken, M. Pierres, and F. W. Fitch. 1984. Characterization of the murine T cell surface molecule, designated L3T4, identified by a monoclonal antibody GK1.5: Similarity of L3T4 to the human Lcu3/T4 molecule. J. Immunol. 131:2445.
31. Nakayarmt, E., W. Dippold, H. Shiku. H. F. Oettgcn, and L. J. Old. 1980. Alloantigen-induced T-cell proliferation: Ly phenotvpe of responding cells and blocking of proliferation by Lyt antisera. Proc, Natl. Acad. Sci. USA 77:2890.
32. Shen, F.-W. 1981. Monoclonal antibodies to mouse lymphocyte differentiation alloantigens- In Monoclonal Antibodies and T Cell Hyhridomas. G. J. Haemmerling, U. Haemmerling, and J. F. Kearney, eds. Elsevier/North-Hoiland Biomedical Press. New York, pp. 25- 31.
33. Wysocki. L. J., and V, L Sato. 1978, "Panning" for lymphocytes: A method for cell selection, proc. Natl Acad. Sci. USA 75:2844.
34. Lowemhai. J. W.; P. Corthesy, C. Tougne, R. Lees, H. R. Mac- Donald, and M. Nabholz. 1985. High and low affinity IL-2 receptors: Analysts by IL-2 dissociation rate and reactivity with monoclonal anti-receptor antibody PC61. J. Immunol. 135:3988.
35. Ledbetter, J, A., and L. A. Hcrzenberg. 1979. Xenogenic monoclonal antibodies to mouse lymphoid differentiation antigens- Immunol. Rev. 47:63.
36. Leo, O., M. Foo, D. Sachs, I- E. Samelson, and J. A, Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
37. Kubo. R. T., W. Born, J. W. Kappler, P, Marrack, and M. Pigeon. J989. Characterization of a monoclonal antibody which detects al! murine αβ T cell receptors, J. Immunol. 142:2736.
38. Budd, R., J. Cerottini, C. Horvath, C. Bron. T. PedrazzinL R. Howe, and R. MacDonald. 1987. Distinction of virgin and memory T lymphocytes. J. Immunol. 138:3120.
39. Reicheri, R., M, Gallatin, E. Butcher, and I. Weissman, 1984. A homing receptor-bearing cortical thymocytes subset; implications for thymus cell migration and the nature of cortisone-resistani thymocytes. Cell 38:89.
40. Yokoyarna, W., F, Koning, P. Kehn, G. Pereira, G. Stingl, j. Coligan. and E. Shevach. 1988. Characterization of a cell surface expressed disulfide-linked dimer involved in murine T cell activation. J. Immunol. 141:369.
41. Bottomly, K... M. Luqman, L. Greenbaum, S. Carding, J. West, T. Pasqualini, and D. B. Murphy. 1989, A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur. J. Immunol. 19:617.
42. Tanaka. T., M. Tsudo, H. Karasuyama, F. Kitamura, T. Kono, M. Hatakcyama, T, Taniguchi. and M, Miyasaka. 1991. A novel monoclonal antibody against tnurine IL-2 receptor /3-chain: Characterization of receptor expression in normal lymphoid cells and EL-4 cells, /. Immunol. 147:2222.
43. Brace, J., F. Symington, T. Mckearn, and J. Sprent, 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol 127:2496.
44. Sakaguchi, S., and N. Sakaguchi. 1989. Organ-specific autoimmune diseases induced in mice by elimination of T-cell subset. V. Neonatal administration of cyclosporin A causes autoimmune disease. J. Immunol. 142:471.
45. Biilingham, R. E., and P. B. Medawar. 1951. The technique of free skin grafting in mammals. J. Exp. Biol. 28:385.
46. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Ceil 65:305.
47. Oldstone, M. B. A., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response. Cell 65:319.
48. Heath, W. R., j. Allison, M. W. Hoffmann, G. Schoenrich, G. Haemmerling, B. Arnold, and J. F. A. P. Miller. 1992. Autoimmune diabetes as consequence of locally produced interleukin 2.Nature (Loud.) 359:547.
49. Bottazzo, G. F., R. Pujol-Borrell, T. Hanafusa, and M. Feldman. 1983. Role of aberant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet ii:l 115.
50. Sprent, J., and H. Kosaka. 1993. T cell tolerance and self/non-self discrimination. Autoimmunity 15:155.
51. Oldstone, M. B. A. 1987. Molecular mimicry and autoimmune disease. Cell 50:819.
52. Izui, S., P. J. McConahey, A. N. Theofilopoulos, and F. J. Dixon. 1979. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. J. Exp, Med. 149:1099.
53. Uchiyama, T., S. Broder, and T. A. Waldrnann, 1981. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac(+) cells. J. Immunol. 126:1393.
54. Smith, K. A. 1989. The interleukin 2 receptor. Ami. Rev. Cell Biol. 5:397.
55. Jackson, A. L., H. Matsumoto, M. Janszen, V. Maino, A. Blidy, and S. Sheye. 1990. Restricted expression of p55 interleukin 2 receptor (CD25) on human T cells. Clin. Immunol. Immunopathol. 54:126.
56. + and CD8+ T cells. Immunology 72:15.
57. Bradley, L. M., M. Croft, and S. L. Swain. 1993. T-cell memory:. new perspectives. Immunol Today 14:197.
58. Vitetta, E. S., M. T. Berton, C. Burrger, M. Kepron, W. T. Lee, and X-M. Yin. 1991. Memory B and T cells. Annu. Rev. Immunol. 9:193.
59. + T cells expressing IL-2 receptor a-chain (CD25) and having a functionally transitional nature into memory cells. Int. Immunol. 3:1349.
60. Ramsdell, F., T. Lantz, and B. J. Fowlkes. 1989. A nondeletional mechanism of thymic self tolerance. Science 246:1038.
61. Lamb, J. R., E, D. Zanders, W. Sewed, M. J. Crumpton, M. Feldmann, and M. J. Owen. 1987. Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways. Ear. J. Immunol. 17:1641.
62. + T lymphocytes on immunizing Mls-lb mice with Mis-1a expressing cells. Nature 339:541.
63. Lo, D., L. C. Burkly, R. A. Flavell, R. D. Palmiter, and R. L. Brinster. 1989. Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells. /. Exp. Med. 170:87.
64. Minami, Y., T. Kono, T. Miyazaki, and T. Taniguchi. 1993. The IL-2 receptor complex: Its structure, function, and target genes. Annu. Rev. Immunol 11:245.
65. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
66. Moore, K., A. O'Garra, R. W. Malefyt, P. Vieira, and T. Mosmann. 1993. InterIeukin-10. Annu. Rev. Immunol. 11:165.
67. Sakaguchi, N., K. Miyai, and S. Sakaguchi. 1994. Ionizing radiation and autoimmunity: Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. J. Immunol. 152:2586.
68. Oldstone, M. B. A. 1988. Prevention of type 1 diabetes in nonobese diabetic mice by virus infection. Science 239:500.
69. Like, A. A., D. L. Guberski, and L. Butler. 1991. Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats. Diabetes 40:259.
70. Wilberz, S., H. J. Partke, F. Dagnaes-Hansen, and L. Herberg. 1991.Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice. Oiabetologia 34:2.
71. Sakaguchi, S., and N. Sakaguchi. 1994. Thymus, T cells and autoimmunity: Various causes but a common mechanism of autoimmune disease. In Autoimmunity: Physiology and Disease. A. Coutinho and M. Kazatchkine, eds. Wiley-Liss, New York, pp. 203-227.
72. Glazier, A., P. J. Tutschka, E. R. Farmer, and G. W. Santos. 1983.Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution. J. Exp. Med. 158:1.