Timing is everything: Stochastic origins of cell-to-cell variability in cancer cell death

Frontiers in Bioscience

Volumn 16, Issue 1, 2011, Pages 307-314

  Skommer, Joanna ^a   Raychaudhuri, Subhadip ^b   Wlodkowic, Donald ^c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Davis   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Apoptosis; Cancer; Mitochondria; Review; Stochastic variability; Systems biology

Indexed keywords

APOPTOSIS; BIOLOGICAL MODEL; CELL DEATH; GENETICS; HUMAN; NEOPLASM; REVIEW; STATISTICS; SYSTEMS BIOLOGY;

APOPTOSIS; CELL DEATH; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; STOCHASTIC PROCESSES; SYSTEMS BIOLOGY;

EID: 79955036692     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3689     Document Type: Article

References (30)

1. D.R. Green and G. Kroemer: The pathophysiology of mitochondrial cell death. Science 305, 626-9 (2004) (Pubitemid 39006738)
2. D. Wlodkowic, J. Skommer, D. McGuinness, C. Hillier and Z. Darzynkiewicz: ER-Golgi network-a future target for anti-cancer therapy. Leuk Res 33, 1440-7 (2009)
3. T.N. Chonghaile and A. Letai: Mimicking the BH3 domain to kill cancer cells. Oncogene 27 Suppl 1:S149-57 (2008)
4. A. Letai: BH3 domains as BCL-2 inhibitors: prototype cancer therapeutics. Expert Opin Biol Ther 3, 293-304 (2003) (Pubitemid 36458760)
5. N.L. Fox, R. Humphreys, T.A. Luster, J. Klein and G. Gallant: Tumor necrosis factor-related apoptosisinducing ligand (TRAIL) receptor-1 and receptor-2 agonists for cancer therapy. Expert Opin Biol Ther 10(1), 1-18 (2010)
6. E.G. de Vries, T. Timmer, N.H. Mulder, C.M. van Geelen, W.T. van der Graaf, D.C. Spierings, M.N. de Hooge, J.A. Gietema and S. de Jong: Modulation of death receptor pathways in oncology. Drugs Today 39 Suppl C:95-109 (2003) (Pubitemid 37509404)
7. J. Skommer, Z. Darzynkiewicz, D.Wlodkowic: Cell death goes LIVE: Technological advances in real-time tracking of cell death. Cell Cycle (in press)
8. A.A. Cohen, N. Geva-Zatorsky, E. Eden, M. Frenkel- Morgenstern, I. Issaeva, A. Sigal, R. Milo, C. Cohen- Saidon, Y. Liron, Z. Kam, L. Cohen, T. Danon, N. Perzov and U. Alon: Dynamic proteomics of individual cancer cells in response to a drug. Science 322(5907), 1511-6 (2008)
9. N. Rosenfeld, J.W. Young, U. Alon, P.S. Swain and M.B. Elowitz: Gene regulation at the single-cell level. Science 307(5717), 1962-5 (2005) (Pubitemid 40404705)
10. J.R. Chabot, J.M. Pedraza, P. Luitel and A. van Oudenaarden: Stochastic gene expression out-of-steadystate in the cyanobacterial circadian clock. Nature 450(7173), 1249-52 (2007)
11. S.L. Spencer, S. Gaudet, J.G. Albeck, J.M. Burke and P.K. Sorger: Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459(7245), 428-32 (2009)
12. A. Sigal, R. Milo, A. Cohen, N. Geva-Zatorsky, Y. Klein, Y. Liron, N. Rosenfeld, T. Danon, N. Perzov and Alon U: Variability and memory of protein levels in human cells. Nature 444(7119), 643-6 (2006) (Pubitemid 44864444)
13. M. Rehm, H.J. Huber, C.T. Hellwig, S. Anguissola, H. Dussmann, J.H. Prehn: Dynamics of outer mitochondrial membrane permeabilization during apoptosis. Cell Death Differ 16(4), 613-23 (2009)
14. P. Bastiaens: Systems biology: When it is time to die. Nature, 459(7245), 334-5 (2009)
15. D.T. Gillespie: Exact stochastic simulation of coupled chemical reactions. J Phys Chem, 81, 2340-2361 (1977)
16. S. Raychaudhuri, J. Skommer, K. Henty, N. Birch and T. Brittain: Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Apoptosis 15(4), 401-11 (2010)
17. S. Raychaudhuri, E. Willgohs, T.N. Nguyen, E.M. Khan and T. Goldkorn: Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis. Biophys J 95(8), 3559-62 (2008)
18. J. Skommer, T.Brittain and S. Raychaudhuri: Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death. (submitted)
19. C.T. Hellwig, B.F. Kohler, A.K. Lehtivarjo, H. Dussmann, M.J. Courtney, J.H. Prehn and M. Rehm: Real time analysis of tumor necrosis factor-related apoptosisinducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. J Biol Chem 283(31), 21676-85 (2008)
20. J.G. Albeck, J.M. Burke, S.L. Spencer, D.A. Lauffenburger and P.K. Sorger: Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol 6(12), 2831-52 (2008)
21. F. Michor, T.P. Hughes, Y. Iwasa, S. Branford, N.P. Shah, C.L. Sawyers and M.A. Nowak: Dynamics of chronic myeloid leukaemia. Nature 435(7046), 1267-70 (2005) (Pubitemid 40943094)
22. E. Quintana, M. Shackleton, M.S. Sabel, D.R. Fullen, T.M. Johnson and S.J. Morrison: Efficient tumour formation by single human melanoma cells. Nature 456(7222), 593-8 (2008)
23. R.A. Gatenby, A.S. Silva, R.J. Gillies and B.R. Frieden: Adaptive therapy. Cancer Res 69(11), 4894-903 (2009)
24. M. Collado and M. Serrano: Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 10(1), 51-7 (2010)
25. D. Wlodkowic, J. Skommer and Z. Darzynkiewicz: Cytometry in Cell Necrobiology Revisited. Recent Advances and New Vistas. Cytometry A (in press)
26. D.B. Wheeler, A.E. Carpenter and D.M. Sabatini: Cell microarrays and RNA interference chip away at gene function. Nat Genet 37 Suppl:S25-30 (2005) (Pubitemid 40770400)
27. J.R. Rettig and A. Folch: Large-scale single-cell trapping and imaging using microwell arrays. Anal Chem 77(17), 5628-34 (2005) (Pubitemid 41266059)
28. M.L. Yarmush and K.R. King: Living-cell microarrays. Annu Rev Biomed Eng 11, 235-57 (2009)
29. D. Wlodkowic, S. Faley, M. Zagnoni, J.P. Wikswo and J.M. Cooper: Microfluidic single-cell array cytometry for the analysis of tumor apoptosis. Anal Chem 81(13), 5517-23 (2009)
30. S.L. Faley, M. Copland, D. Wlodkowic, W. Kolch, K.T. Seale, J.P. Wikswo and J.M. Cooper: Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Lab Chip 9(18), 2659-64 (2009)