Intra-tablet coating variability for several pharmaceutical tablet shapes

Chemical Engineering Science

Volumn 66, Issue 12, 2011, Pages 2535-2544

  Freireich, Ben ^a   Ketterhagen, William R ^b   Wassgren, Carl ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Coating; Computation; Granular materials; Particle processing; Pharmaceuticals; Variability

Indexed keywords

A-COEFFICIENT; AREA RATIOS; ASYMPTOTIC VALUES; BED SURFACE; COATING THICKNESS; COEFFICIENT OF VARIATION; COEFFICIENTS OF VARIATIONS; COMPUTATION; DEM SIMULATION; DISCRETE ELEMENT METHOD; FILL LEVEL; MONTE CARLO SIMULATION; NON-SPHERICAL; PARTICLE PROCESSING; PHARMACEUTICAL TABLETS; PHARMACEUTICALS; PREFERRED ORIENTATIONS; RELATIVE ORDER; SQUARE ROOTS; TABLET COATINGS; VARIABILITY;

ASPECT RATIO; COMPUTER SIMULATION; DRUG PRODUCTS; GRANULAR MATERIALS; MONTE CARLO METHODS; PARTICLES (PARTICULATE MATTER); THICKNESS MEASUREMENT;

COATINGS;

EID: 79955034743     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2011.02.052     Document Type: Article

References (21)

1. Altman S. Rotations, Quaternions, and Double Groups 2005, Dover.
2. Devroye L. Non-Uniform Random Variate Generation 1986, Springer-Verlag.
3. Di Renzo A., Di Maio F.P. Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes. Chemical Engineering Science 2004, 59:525-541.
4. Freireich B., Litster J., Wassgren C. Using the discrete element method to predict collision-scale behavior: a sensitivity analysis. Chemical Engineering Science 2009, 64:3407-3416.
5. Freireich B., Wassgren C. Intra-particle coating variability: analysis and Monte-Carlo simulations. Chemical Engineering Science 2010, 65:1117-1124.
6. Heywood H. Particle shape coefficients. Journal of the Imperial College Chemical Engineering Society 1954, 8:25-33.
7. Ho L., Müller R., Römer M., Gordon K.C., Heinämäki J., Kleinebudde, Pepper M., Rades T., Shen Y.C., Strachan C.J., Taday P.F., Zeitler J.A. Analysis of sustained-release tablet film coats using terahertz pulsed imaging. Journal of Controlled Release 2007, 119(3):253-261.
8. Ji S., Shen H. Effect of contact force models on granular flow dynamics. Journal of Engineering Mechanics 2006, 132:1252-1259.
9. Kalbag A., Wassgren C. Inter-tablet coating variability: tablet residence time variability. Chemical Engineering Science 2009, 64(11):2705-2717.
10. Ketterhagen, W.R., 2011. Modeling the motion and orientation of various pharmaceutical tablet shapes in a film coating pan using DEM. Int. J Pharm., In press.
11. Kodam M., Bharadwaj R., Curtis J., Hancock B., Wassgren C. Force model considerations for glued-sphere discrete element method simulations. Chemical Engineering Science 2009, 64(15):3466-3475.
12. Kruggel-Emden H., Rickelt S., Wirtz S., Scherer V. A study on the validity of the multi-sphere discrete element method. Powder Technology 2008, 188(2):153-165.
13. Langston P.A., Tüzün U., Heyes D.M. Discrete element simulation of granular flow in 2D and 3D hoppers: dependence of discharge rate and wall stress on particle interactions. Chemical Engineering Science 1995, 50(6):967-987.
14. Madamba M.C., Mullet W.M., Debnath S., Kwong E. Characterization of tablet film coatings using a laser-induced breakdown spectroscopic technique. AAPS PharmSciTech 2007, 8(4). Article 103.
15. Mellman J. The transverse motion of solids in rotating cylinders-forms of motion and transition behavior. Powder Technology 2001, 118:251-270.
16. Müller J., Knop K., Thies J., Uerpmann C., Kleinebudde P. Feasibility of Raman spectroscopy as a PAT tool in active coating. Drug Development and Industrial Pharamacy 2010, 36(2):234-243.
17. Pérez-Ramos, J.D, 2007. Monitoring and modeling of film coating in a side vented pan coater using near-infrared reflectance spectroscopy, digital video imaging, and computational methods, Ph.D. Thesis, Purdue University, West Lafayette, IN.
18. Shoemake K. Uniform random rotations. Graphic Gems III 1992, Academic Press. D. Kirk (Ed.).
19. Song Y., Turton R., Kayihan F. Contact detection algorithms for DEM simulations of tablet-shaped particles. Powder Technology 2006, 161:32-40.
20. Taday P.F. Terahertz pulsed imaging for nondestructive testing of pharmaceutical products. Spectroscopy 2008, 24(4):28-36.
21. Wilson K.E., Crossman E. The influence of tablet shape and pan speed on intra-tablet film coating uniformity. Drug Development and Industrial Pharmacy 1997, 23(12):1239-1243.