In vitro assessment of the differentiation potential of bone marrow-derived mesenchymal stem cells on genipin-chitosan conjugation scaffold with surface hydroxyapatite nanostructure for bone tissue engineering

Tissue Engineering - Part A

Volumn 17, Issue 9-10, 2011, Pages 1341-1349

  Wang, Guancong ^a   Zheng, Lin ^a   Zhao, Hongshi ^a   Miao, Junying ^a   Sun, Chunhui ^a   Ren, Na ^a   Wang, Jiyang ^a   Liu, Hong ^a   Tao, Xutang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINITY; APATITE; BIOLOGICAL MATERIALS; BIOMATERIALS; BIOMIMETICS; BONE; CELL CULTURE; CHITIN; CHITOSAN; CROSSLINKING; ENZYME ACTIVITY; GROWTH KINETICS; HYDROXYAPATITE; NANOSTRUCTURES; PHOSPHATASES; PHOSPHATE MINERALS; POLYMERASE CHAIN REACTION; PRESSURE EFFECTS; STEM CELLS; SURFACE TOPOGRAPHY; TRANSCRIPTION FACTORS;

ALIZARIN RED; ALKALINE PHOSPHATASE ACTIVITY; BIOMIMETIC APATITES; BONE MARROW-DERIVED MESENCHYMAL STEM CELLS; BONE TISSUE ENGINEERING; CELL LINEAGE; CELL SHAPES; CHEMICAL COMPOSITIONS; CROSS LINKED CHITOSAN; CYTOSKELETONS; GENIPIN; IN-VITRO; MINERALIZED EXTRACELLULAR MATRIXES; MRNA EXPRESSION; NANOTOPOGRAPHIES; OSTEOCALCIN; OSTEOGENIC; OSTEOGENIC DIFFERENTIATION; OSTEOPONTIN; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; RAT BONE MARROW; SURFACE CHARACTERISTICS;

SCAFFOLDS (BIOLOGY);

RATTUS;

BIOMIMETIC MATERIAL; CHITOSAN; DIFFERENTIATION ANTIGEN; GENIPIN; HYDROXYAPATITE; IRIDOID; NANOMATERIAL; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE DEVELOPMENT; BONE MARROW; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; CYTOSKELETON; MALE; MESENCHYMAL STEM CELL; METABOLISM; METHODOLOGY; RAT; TISSUE ENGINEERING; WISTAR RAT;

ANIMALS; ANTIGENS, DIFFERENTIATION; BIOMIMETIC MATERIALS; BONE MARROW; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELLS, CULTURED; CHITOSAN; CYTOSKELETON; DURAPATITE; IRIDOID GLYCOSIDES; MALE; MESENCHYMAL STEM CELLS; NANOSTRUCTURES; OSTEOGENESIS; RATS; RATS, WISTAR; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 79955009111     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2010.0497     Document Type: Article

References (46)

1. Rose, F.R., and Oreffo, R.O. Bone tissue engineering: hope vs hype. Biochem biophys commun 292, 1, 2002.
2. Linkhart, T.A., Mohan, S., and Baylink, D.J. Growth factors for bone growth and repair: IGF, TGFb and BMP. Bone 19, 1S, 1996.
3. Ohgushi, H., Kotobuki, N., Funaoka, H., Machida, H., Hirose, M., Tanaka, Y., and Takakura, Y. Tissue engineered ceramic artificial joint-ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis. Biomaterials 26, 4654, 2005.
4. Rahaman, M.N., and Mao, J.J. Stem cell-based composite tissue constructs for regenerative medicine. Biotechnol Bioeng 91, 261, 2005.
5. Stevens, M.M., and George, J.H. Exploring and engineering the cell surface interface. Science 310, 1135, 2005.
6. Dalby, M.J., Gadegaard, N., Tare, R., Andar, A., Riehle, M.O., Herzyk, P., Wilkinson, C.D., and Oreffo, R.O. the control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nat Mater 6, 997, 2007.
7. Bettinger, C.J., Zhang, Z., Gerecht, S., Borenstein, J.T., and Langer, R. Enhancement of in vitro capillary tube formation by substrate nanotopography. Adv Mater 20, 99, 2008.
8. Brammer, K.S., Oh, S., Gallagher, J.O., and Jin, S. Enhanced cellular mobility guided by TiO2 nanotube surfaces. Nano Lett 8, 786, 2008.
9. Kaur, G., Valarmathi, M.T., Potts, J.D., Jabbari, E., Sabo- Attwood, T., and Wang, Q. Regulation of osteogenic differentiation of rat bone marrow stromal cells on 2D nanorod substrates. Biomaterials 31, 1732, 2010.
10. Mendonca, G., Mendonca, D.B., Simoes, L.G., Araujo, A.L., Leite, E.R., Duarte, W.R., Aragao, F.J., and Cooper, L.F. The effects of implant surface nanoscale features on osteoblastspecific gene expression. Biomaterials 30, 4053, 2009.
11. Christopherson, G.T., Song, H., and Mao, H.Q. The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials 30, 556, 2009.
12. Kokubo, T., and Takadama, H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 27, 2907, 2006.
13. Kokubo, T., Kim, H.M., and Kawashita, M. Novel bioactive materials with different mechanical properties. Biomaterials 24, 2161, 2003.
14. Kim, S.S., Park, M.S., Gwak, S.J., Choi, C.Y., and Kim, B.S. Accelerated bonelike apatite growth on porous polymer/ ceramic composite scaffolds in vitro. Tissue Eng 12, 2997, 2006.
15. Li, X., Xie, J., Lipner, J., Yuan, X., Thomopoulos, S., and Xia, Y. Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett 9, 2763, 2009.
16. Zhang, R., and Ma, P.X. Porous poly(l-lactic acid)/apatite composites created by biomimetic process. J Biomed Mater Res 45, 285, 1999.
17. Burdick, J.A., and Vunjak-Novakovic, G. Engineered microenvironments for controlled stem cell differentiation. Tissue Eng Part A 15, 205, 2009.
18. Ma, P.X. Biomimetic materials for tissue engineering. Biomaterials 24, 4353, 2003.
19. Vogel, V., and Sheetz, M. Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol 7, 265, 2006.
20. Bettinger, C.J., Langer, R., and Borenstein, J.T. Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl 48, 5406, 2009.
21. Guilak, F., Cohen, D.M., Estes, B.T., Gimble, J.M., Liedtke, W., and Chen, C.S. Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell 5, 17, 2009.
22. Geiger, B., Spatz, J.P., and Bershadsky, A.D. Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 10, 21, 2009.
23. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
24. Wang, N., Xie, K., Huo, S.W., Zhao, J., Zhang, S., and Miao, J. Suppressing phosphatidylcholine- specific phospholipase C and elevating ROS level, NADPH oxidase activity and Rb level induced neuronal differentiation in mesenchymal stem cells. J Cell Biochem 100, 1548, 2007.
25. Livak, K.J., and Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCt method. Method 25, 402, 2001.
26. Gough, J.E., Jones, J.R., and Hench, L.L. Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold. Biomaterials 25, 2039, 2004.
27. Fu, Q., Rahaman, M.N., Bal, B.S., and Brown, R.F. In vitro cellular response to hydroxyapatite scaffolds with oriented pore architectures. Mater Sci Eng C 20, 2147, 2009.
28. Choi, Y.A., Lim, J., Kim, K.M., Acharya, B., Cho, J.Y., Bae, Y.C., Shin, H.I., Kim, S.Y., and Park, E.K. Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation. J Proteome Res 9, 2947, 2010.
29. Carey, L.E., Xu, H.H., Simon, C.G.Jr., Takagi, S., and Chow, L.C. Premixed rapid-setting calcium phosphate composites for bone repair. Biomaterials 26, 5002, 2005.
30. Zhang, Y., Ni, M., Zhang, M., and Ratner, B. Calcium phosphate-chitosan composite scaffolds for bone tissue engineering. Tissue Eng 9, 337, 2003.
31. Byers, B.A., and García, A.J. Exogenous Runx2 expression enhances in vitro osteoblastic differentiation and mineralization in primary bone marrow stromal cells. Tissue Eng 10, 1623, 2004.
32. Jankovska, I., Pilmane, M., and Urtane, I. Osteopontin and osteocalcin in maxilla tissue of skeletal class III patients. Stomatologija 11, 125, 2009.
33. Ekaputra, A.K., Zhou, Y., Cool, S.M., and Hutmacher, D.W. Composite electrospun scaffolds for engineering tubular bone grafts. Tissue Eng Part A 15, 3779, 2009.
34. Spiegelman, B.M., and Ginty, C.A. Fibronectin modulation Of cell shape and lipogenic gen eexpression in 3T3-adipocytes. Cell 35, 657, 1983.
35. Thomas, C.H., Collier, J.H., Sfeir, C.S., and Healy, K.E. Engineering gene expression and protein synthesis by modulating nu-clear shape. Proc Natl Acad Sci USA 99, 1972, 2002.
36. Dalby, M.J., Biggs, M.J., Gadegaard, N., Kalna, G., Wilkinson, C.D., and Curtis, A.S. Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning. J Cell Biochem 100, 326, 2007.
37. Yim, E.K., Darling, E.M., Kulangara, K., Guilak, F., and Leong, K.W. Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomaterials 31, 1299, 2010.
38. Beck, Jr.G.R., Sullivan, E.C., Moran, E., and Zerler, B. Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in differentiating MC3T3-E1 osteoblasts. J Cell Biochem 68, 269, 1998.
39. Beck, Jr.G.R, Zerler, B., and Moran, E. Phosphate is a specific signal for induction of osteopontin gene expression. J Cell Biochem 97, 8352, 2000.
40. Beck, G.R., Jr. Inorganic phosphate as a signaling molecule in osteoblast differentiation. J Cell Biochem 90, 234, 2003.
41. Zaidi, S.K., Javed, A., Choi, J.Y., van Wijnen, A.J., Stein, J.L., Lian, J.B., and Stein, G.S. A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. J Cell Sci 114, 3093, 2001.
42. Sasano, Y., Zhu, J.X., Kamakura, S., Kusunoki, S., Mizoguchi, I., and Kagayama, M. Expression of major bone extracellular matrix proteins during embryonic osteogenesis in rat mandibles. Anat Embryol (Berl) 202, 31, 2000.
43. McBeath, R., Pirone, D.M., Nelson, C.M., Bhadriraju, K., and Chen, C.S. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6, 483, 2004.
44. Song, J., Malathong, V., and Bertozzi, C.R. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc 127, 3366, 2005.
45. Kikuchi, M., Itoh, S., Ichinose, S., Shinomiya, K., and Tanaka, J. Selforganization mechanism in a bone-like hydroxyapatite/ collagen nanocomposite synthesized in vitro and its biological reaction in vivo. Biomaterials 22, 1705, 2001.
46. Bradt, J., Mertig, M., Teresiak, A., and Pompe, W. Biomimetic mineralization of collagen by combined fibril assembly and calcium phosphate formation. Chem Mater 11, 2694, 1999.