Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting KUANG

RNA

Volumn 17, Issue 5, 2011, Pages 892-902

  Shen, Kuang ^a   Zhang, Xin ^b   Shan, Shu Ou ^a  

^a California Institute of Technology   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Catalytic RNA; Fluorescence; GTPases; Protein targeting; Signal Recognition Particle

Indexed keywords

PROTEIN FTSY; RECEPTOR PROTEIN; RNA; SIGNAL RECOGNITION PARTICLE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DISSOCIATION; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN TARGETING; RIBOSOME; RNA TRANSLATION;

BACTERIAL PROTEINS; ESCHERICHIA COLI; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN TRANSPORT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RIBOSOMES; RNA; SIGNAL RECOGNITION PARTICLE;

EID: 79955005771     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2610411     Document Type: Article

References (36)

1. Batey RT, Rambo RP, Lucast L, Rha B, Doudna JA. 2000. Crystal structure of the ribonucleoprotein core of the signal recognition particle. Science 287: 1232-1239. (Pubitemid 30112139)
2. Bradshaw N, Neher SB, Booth DS, Walter P. 2009. Signal sequences activate the catalytic switch of SRP RNA. Science 323: 127-130.
3. Buskiewicz I, Peske F, Wieden HJ, Gryczynski I, Rodnina MV, Wintermeyer W. 2005. Conformations of the signal recognition particle protein Ffh from Escherichia coli as determined by FRET. J Mol Biol 351: 417-430. (Pubitemid 41007759)
4. Egea PF, Shan SO, Napetschnig J, Savage DF, Walter P, Stroud RM. 2004. Substrate twinning activates the signal recognition particle and its receptor. Nature 427: 215-221. (Pubitemid 38112032)
5. Estrozi LF, Boehringer D, Shan SO, Ban N, Schaffitzel C. 2011. Cryo- EM structure of the E. coli translating ribosome in complex with SRP and its receptor. Nat Struct Mol Biol 18: 88-90.
6. Flanagan JJ, Chen JC, Miao Y, Shao Y, Lin J, Bock PE, Johnson AE. 2003. Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens. J Biol Chem 278: 18628-18637. (Pubitemid 36799490)
7. Focia PJ, Shepotinovskaya IV, Seidler JA, Freymann DM. 2004. Heterodimeric GTPase core of the SRP targeting complex. Science 303: 373-377. (Pubitemid 38095777)
8. Freymann DM, Keenan RJ, Stroud RM, Walter P. 1997. Structure of the conserved GTPase domain of the signal recognition particle. Nature 385: 361-364. (Pubitemid 27053109)
9. Gilmore R, Blobel G, Walter P. 1982a. Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol 95: 463-469. (Pubitemid 13215861)
10. Gilmore R, Walter P, Blobel G. 1982b. Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol 95: 470-477. (Pubitemid 13215862)
11. Gu SQ, Peske F, Wieden HJ, Rodnina MV, Wintermeyer W. 2003. The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome. RNA 9: 566-573. (Pubitemid 36505454)
12. Halic M, Becker T, Pool MR, Spahn CM, Grassucci RA, Frank J, Beckmann R. 2004. Structure of the signal recognition particle interacting with the elongation-arrested ribosome. Nature 427: 808-814. (Pubitemid 38297736)
13. Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R. 2006. Following the signal sequence from ribosomal tunnel exit to signal recognition particle. Nature 444: 507-511. (Pubitemid 44809070)
14. Janda CY, Li J, Oubridge C, Hernandez H, Robinson CV, Nagai K. 2010. Recognition of a signal peptide by the signal recognition particle. Nature 465: 507-510.
15. Keenan RJ, Freymann DM, Walter P, Stroud RM. 1998. Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell 94: 181-191. (Pubitemid 28348006)
16. Moazed D, Noller HF. 1989. Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites. Cell 57: 585-597. (Pubitemid 19140644)
17. Montoya G, Svensson C, Luirink J, Sinning I. 1997. Crystal structure of the NG domain from the signal-recognition particle receptor FtsY. Nature 385: 365-368. (Pubitemid 27053110)
18. Peluso P, Herschlag D, Nock S, Freymann DM, Johnson AE, Walter P. 2000. Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor. Science 288: 1640-1643. (Pubitemid 30387429)
19. Peluso P, Shan SO, Nock S, Herschlag D, Walter P. 2001. Role of SRP RNA in the GTPase cycles of ffh and FtsY. Biochemistry 40: 15224-15233. (Pubitemid 33151937)
20. Pool MR, Stumm J, Fulga TA, Sinning I, Dobberstein B. 2002. Distinct modes of signal recognition particle interaction with the ribosome. Science 297: 1345-1348. (Pubitemid 34913172)
21. Rosendal KR, Wild K, Montoya G, Sinning I. 2003. Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication. Proc Natl Acad Sci 100: 14701-14706. (Pubitemid 37517954)
22. Schaffitzel C, Ban N. 2007. Generation of ribosome nascent chain complexes for structural and functional studies. J Struct Biol 158: 463-471. (Pubitemid 46764575)
23. Schaffitzel C, Oswald M, Berger I, Ishikawa T, Abrahams JP, Koerten HK, Koning RI, Ban N. 2006. Structure of the E-coli signal recognition particle bound to a translating ribosome. Nature 444: 503-506. (Pubitemid 44809069)
24. Shan SO, Stroud RM, Walter P. 2004. Mechanism of association and reciprocal activation of two GTPases. PLoS Biol 2: 1572-1581.
25. Shen K, Shan SO. 2010. Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting. Proc Natl Acad Sci 107: 7698-7703.
26. Siegel V, Walter P. 1988. The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J 7: 1769-1775.
27. Siu FY, Spanggord RJ, Doudna JA. 2007. SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. RNA 13: 240-250. (Pubitemid 46147899)
28. Spanggord RJ, Siu F, Ke AL, Doudna JA. 2005. RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. Nat Struct Mol Biol 12: 1116-1122. (Pubitemid 41746783)
29. Ullers RS, Houben EN, Raine A, ten Hagen-Jongman CM, Ehrenberg M, Brunner J, Oudega B, Harms N, Luirink J. 2003. Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome. J Cell Biol 161: 679-684. (Pubitemid 36648750)
30. Walter P, Johnson AE. 1994. Signal sequence recognition and protein targeting to the endoplasmic-reticulum membrane. Annu Rev Cell Biol 10: 87-119. (Pubitemid 24372817)
31. Zhang X, Kung S, Shan SO. 2008. Demonstration of a multistep mechanism for assembly of the SRP-SRP receptor complex: Implications for the catalytic role of SRP RNA. J Mol Biol 381: 581-593.
32. Zhang X, Schaffitzel C, Ban N, Shan SO. 2009. Multiple conformational switches in a GTPase complex control co-translational protein targeting. Proc Natl Acad Sci 106: 1754-1759.
33. Zhang X, Rashid R, Wang K, Shan SO. 2010. Sequential checkpoints govern substrate selection during cotranslational protein targeting. Science 328: 757-760.
34. Zhang X, Lam VQ, Mou Y, Kimura T, Chung J, Chandrasekar S, Winkler JR, Mayo SL, Shan SO. 2011. Direct visualization reveals dynamics of a transient intermediate during protein assembly. Proc Natl Acad Sci (in press).
35. Zheng N, Gierasch LM. 1996. Signal sequences: The same yet different. Cell 86: 849-852. (Pubitemid 26336788)
36. Zopf D, Bernstein HD, Johnson AE, Walter P. 1990. The methioninerich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence. EMBO J 9: 4511-4517. (Pubitemid 120026009)