Injection of Wild Type Embryonic Stem Cells into Mst1 Transgenic Blastocysts Prevents Adult-Onset Cardiomyopathy

Stem Cell Reviews and Reports

Volumn 7, Issue 2, 2011, Pages 326-330

  Zhao, Qingshi ^a   Beck, Amanda J ^a   Vitale, Joseph M ^a   Schneider, Joel S ^a   Chang, Corey ^a   Gao, Shumin ^a   del Re, Dominic ^a   Bhaumik, Mantu ^b   Yehia, Ghassan ^a   Sadoshima, Junichi ^a   Fraidenraich, Diego ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Cardiomyopathy; Chimera; ESCs; Mst1

Indexed keywords

PROTEIN SERINE THREONINE KINASE; STK4 PROTEIN, HUMAN;

ANIMAL; ARTICLE; BLASTOCYST; C57BL MOUSE; CARDIOMYOPATHY; CYTOLOGY; EMBRYONIC STEM CELL; FEMALE; GENETICS; HEART MUSCLE; HUMAN; MALE; METABOLISM; MOUSE; PATHOLOGY; TRANSGENIC MOUSE; TRANSPLANTATION; UPREGULATION;

ANIMALS; BLASTOCYST; CARDIOMYOPATHIES; EMBRYONIC STEM CELLS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIUM; PROTEIN-SERINE-THREONINE KINASES; UP-REGULATION;

MAMMALIA; MUS;

EID: 79954998481     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-010-9206-6     Document Type: Article

References (15)

1. Schneider, J. S., Vitale, J. M., Terzic, A., & Fraidenraich, D. (2009). Blastocyst injection of embryonic stem cells: a simple approach to unveil mechanisms of corrections in mouse models of human disease. Stem Cell Reviews and Reports, 5(4), 369-377.
2. Zhao, Q., et al. (2009). Rescue of developmental defects by blastocyst stem cell injection: towards elucidation of neomorphic corrective pathways. Journal of Cardiovascular Translational Research, 3(1), 66.
3. Fraidenraich, D., & Benezra, R. (2006). Embryonic stem cells prevent developmental cardiac defects in mice. Nature Clinical Practice. Cardiovascular Medicine, 3(Suppl 1), S14-17.
4. Fraidenraich, D., et al. (2004). Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science, 306(5694), 247-252.
5. Chien, K. R., Moretti, A., & Laugwitz, K. L. (2004). Development. ES cells to the rescue. Science, 306(5694), 239-240.
6. Cossu, G., & Sampaolesi, M. (2007). New therapies for Duchenne muscular dystrophy: challenges, prospects and clinical trials. Trends in Molecular Medicine, 13(12), 520-526.
7. Durbeej, M., & Campbell, K. P. (2002). Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models. Current Opinion in Genetics & Development, 12(3), 349-361.
8. Bulfield, G., Siller, W. G., Wight, P. A., & Moore, K. J. (1984). X chromosome-linked muscular dystrophy (mdx) in the mouse.Proceedings of the National Academy of Sciences of the United States of America, 81(4), 1189-1192.
9. Stillwell, E., et al. (2009). Blastocyst injection of wild type embryonic stem cells induces global corrections in mdx mice. PLoS ONE, 4(3), e4759.
10. Yamada, S., et al. (2009). Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype. Stem Cells, 27(7), 1697-1705.
11. Ling, P., Lu, T. J., Yuan, C. J., & Lai, M. D. (2008). Biosignaling of mammalian Ste20-related kinases. Cellular Signalling, 20(7), 1237-1247.
12. Radu, M., & Chernoff, J. (2009). The DeMSTification of mammalian Ste20 kinases. Current Biology, 19(10), R421-425.
13. Yamamoto, S., et al. (2003). Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. Journal of Clinical Investigation, 111(10), 1463-1474.
14. Odashima, M., et al. (2007). Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circulation Research, 100(9), 1344-1352.
15. Peter, P. S., et al. (2007). Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor. Journal of Clinical Investigation, 117(5), 1335-1343.