Differential changes in expression of intestinal antimicrobial peptide genes during ascarislumbricoides infection in zambian adults do not respond to helminth eradication

Journal of Infectious Diseases

Volumn 203, Issue 10, 2011, Pages 1464-1473

  Kapulu, Melissa C ^a,d   Simuyandi, Michelo ^b   Sianongo, Sandie ^b   Mutale, Mubanga ^b   Katubulushi, Max ^b   Kelly, Paul ^b,c  

^a Biological Sciences Department   (Zambia)

^b UNIVERSITY OF ZAMBIA   (Zambia)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; ALPHA DEFENSIN; BETA DEFENSIN; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 22; IVERMECTIN; POLYPEPTIDE ANTIBIOTIC AGENT; PRAZIQUANTEL; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; ASCARIASIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; EXPRESSION VECTOR; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REPRESSION; HELMINTHIASIS; HUMAN; INTESTINE ENDOSCOPY; MALE; MIXED INFECTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMIASIS MANSONI; SINGLE DRUG DOSE; STRONGYLOIDIASIS; T LYMPHOCYTE; TAENIASIS; TH1 GENE; UPREGULATION; ZAMBIA;

ADULT; ANIMALS; ANTHELMINTICS; ANTIMICROBIAL CATIONIC PEPTIDES; ASCARIASIS; ASCARIS LUMBRICOIDES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTESTINES; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTE SUBSETS; YOUNG ADULT; ZAMBIA;

EID: 79954996812     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir035     Document Type: Article

References (37)

1. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: The great neglected tropical diseases. J Clin Invest 2008; 118:1311-21. (Pubitemid 351500423)
2. Wang LJ, Cao Y, Shi HN. Helminth infections and intestinal inflammation. World J Gastroenterol 2008; 14:5125-32.
3. Maizels RM, Pearce EJ, Artis D, Yazdanbakhsh M, Wynn TA. Regulation of pathogenesis and immunity in helminth infections. J Exp Med 2009; 206:2059-66.
4. Elliott AM, Kizza M, Quigley MA, et al. The impact of helminths on the response to immunization and on the incidence of infection and disease in childhood in Uganda: Design of a randomized, double-blind, placebo-controlled, factorial trial of deworming interventions delivered in pregnancy and early childhood [ISRCTN32849447]. Clin Trials 2007; 4:42-57.
5. Cooper PJ, Chico M, Sandoval C, et al. Human infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgR. Infect Immun 2001; 69:1574-80. (Pubitemid 32187611)
6. Harris JB, Podolsky MJ, Bhuiyan TR, et al. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl Trop Dis 2009; 3:e403.
7. Cooper PJ. Mucosal immunology of geohelminth infections in humans. Mucosal Immunol 2009; 2:288-99.
8. Liu Q, Sundar K, Mishra PK, et al. Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms. Infect Immun 2009; 77:5347-58.
9. de Silva HJ, de Silva NR, de Silva AP, Jewell DP. Emergence of inflammatory bowel disease 'beyond theWest': Do prosperity and improved hygiene have a role? Trans R Soc TropMed Hyg 2008; 102:857-60.
10. Summers RW, Elliott DE, Urban JJF, Thompson RA, Weinstock JV. Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial. Gastroenterology 2005; 128:825-32. (Pubitemid 40523535)
11. Yazdanbakhsh M, Tai P, Spry C, Gleich G, Roos D. Synergism between eosinophil cationic protein and oxygen metabolites in killing of schistosomula of Schistosoma mansoni. J Immunol 1987; 138:3443-7. (Pubitemid 17071931)
12. Else KJ, Grencis RK. Helper T-cell subsets in mouse trichuriasis. Parasitol Today 1991; 7:313-6. (Pubitemid 121007897)
13. Artis D, Humphreys NE, Bancroft AJ, Rothwell NJ, Potten CS, Grencis RK. Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection. J Exp Med 1999; 190:953-62. (Pubitemid 29480824)
14. Artis D, Shapira S, Mason N, et al. Differential requirement for NF-kappaB family members in control of helminth infection and intestinal inflammation. J Immunol 2002; 169:4481-7. (Pubitemid 35178225)
15. deSchoolmeester ML, Manku H, Else KJ. The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response. Infect Immun 2006; 74:6280-6.
16. Ohnmacht C, Voehringer D. Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells. J Immunol 2010; 184:344-50.
17. Helmby H, Grencis Richard K. Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection. Eur J Immunol 2003; 33:2974-9. (Pubitemid 37428329)
18. Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 2003; 422:522-6. (Pubitemid 36433647)
19. Islam D, Bandholtz L, Nilsson J, et al. Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 2001; 7:180-5. (Pubitemid 32148484)
20. Kelly P, Bajaj-Elliott M, Katubulushi M, et al. Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults. J Infect Dis 2006; 193:1464-70.
21. Salzman NH, Hung K, Haribhai D, et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2009; 11:76-82.
22. Mclaren DJ. mckean JR, Olsson I, Venge P, Kay AB. Morphological studies on the killing of schistosomula of Schistosoma mansoni by human eosinophil and neutrophil cationic proteins in vitro. Parasite Immunol 1981; 3:359-73. (Pubitemid 12216776)
23. Datta R, deSchoolmeester ML, Hedeler C, Paton NW, Brass AM, Else KJ. Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite. Infect Immun 2005; 73:4025-33. (Pubitemid 40923142)
24. Wehkamp J, Schauber J, Stange EF. Defensins and cathelicidins in gastrointestinal infections. Curr Opin Gastroenterol 2007; 23:32-8. (Pubitemid 44875907)
25. Kelly P, Todd J, Sianongo S, et al. Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count. BMC Gastroenterol 2009; 9:7.
26. Dhaliwal W, Bajaj-Elliott M, Kelly P. Intestinal defensin gene expression in human populations. Mol Immunol 2003; 40: 469-75. (Pubitemid 37244040)
27. Turner Joseph D, Faulkner H, Kamgno J, et al. Th2 cytokines are associated with reduced worm burdens in a human intestinal helminth infection. J Infec Dis 2003; 188:1768-75. (Pubitemid 38010689)
28. Cooper PJ, Chico Martha E, Sandoval C, et al. Human infection with Ascaris lumbricoides is associated with a polarized cytokine response. J Infect Dis 2000; 182:1207-13.
29. Dhaliwal W, Kelly P, Bajaj-Elliott M. Differential effects of staphylococcal enterotoxin B-mediated immune activation on intestinal defensins. Clin Exp Immunol 2009; 156:263-70.
30. Helmby H. Gastrointestinal nematode infection exacerbates malariainduced liver pathology. J Immunol 2009; 182:5663-71.
31. Laurence A, O'Shea JJ, Watford WT. Interleukin-22: A sheep in wolf's clothing. Nat Med 2008; 14:247-9. (Pubitemid 351347904)
32. Colonna M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity 2009; 31:15-23.
33. Naito T, Shiohara T, Hibi T, Suematsu M, Ishikawa H. RORct is dispensable for the development of intestinal mucosal T cells. Mucosal Immunol 2008; 1:198-207. (Pubitemid 351541305)
34. Sukhdeo MVK, O'Grady RT, Hsu SC. The site selected by the larvae of Heligmosomoides polygyrus. J Helminthol 1984; 58:19-23.
35. Harn DA, McDonald J, Atochina O, Da'dara AA. Modulation of host immune responses by helminth glycans. Immunol Rev 2009; 230:247-57.
36. Borkow G, Bentwich Z. Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: Role of hyporesponsiveness and anergy. ClinMicrobiol Rev 2004; 17:1012-30. (Pubitemid 39372528)
37. Dhaliwal W, Shawa T, Khanam M, et al. Intestinal antimicrobial gene expression: Impact of micronutrients in malnourished adults during a randomized trial. J Infect Dis 2010; 202:971-8.