Differential requirements for Th1 and Th17 responses to a systemic self-antigen

Journal of Immunology

Volumn 186, Issue 8, 2011, Pages 4668-4673

  Katzman, Shoshana D ^a   Gallo, Eugenio ^a   Hoyer, Katrina K ^a   Abbas, Abul K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD86 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL INTERACTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; INFLAMMATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL TIME; TH1 CELL; TH17 CELL;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD40; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN; TH1 CELLS; TH17 CELLS;

EID: 79954993362     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1003786     Document Type: Article

References (25)

1. Harrington, L. E., P. R. Mangan, and C. T. Weaver. 2006. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 18:349-356.
2. Martinez, G. J., R. I. Nurieva, X. O. Yang, and C. Dong. 2008. Regulation and function of proinflammatory TH17 cells. Ann. N. Y. Acad. Sci. 1143:188-211.
3. *). Annu. Rev. Immunol. 28:445-489.
4. Bouguermouh, S., G. Fortin, N. Baba, M. Rubio, and M. Sarfati. 2009. CD28 costimulation down regulates Th17 development. PLoS ONE 4: e5087.
5. Weigmann, B., H. A. Lehr, G. Yancopoulos, D. Valenzuela, A. Murphy, S. Stevens, J. Schmidt, P. R. Galle, S. Rose-John, and M. F. Neurath. 2008. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. J. Exp. Med. 205:2099-2110.
6. Dardalhon, V., T. Korn, V. K. Kuchroo, and A. C. Anderson. 2008. Role of Th1 and Th17 cells in organ-specific autoimmunity. J. Autoimmun. 31:252-256.
7. Katzman, S. D., W. E. O'Gorman, A. V. Villarino, E. Gallo, R. S. Friedman, M. F. Krummel, G. P. Nolan, and A. K. Abbas. 2010. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc. Natl. Acad. Sci. USA 107:18085-18090.
8. Lohr, J., B. Knoechel, D. Caretto, and A. K. Abbas. 2009. Balance of Th1 and Th17 effector and peripheral regulatory T cells. Microbes Infect. 11:589-593.
9. Lohr, J., B. Knoechel, J. J. Wang, A. V. Villarino, and A. K. Abbas. 2006. Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J. Exp. Med. 203:2785-2791. (Pubitemid 46026156)
10. Wildbaum, G., Y. Zohar, and N. Karin. 2010. Antigen-specific CD25-Foxp3-IFN-gamma (high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am. J. Pathol. 176:2764-2775.
11. Benvenuti, F., C. Lagaudrière-Gesbert, I. Grandjean, C. Jancic, C. Hivroz, A. Trautmann, O. Lantz, and S. Amigorena. 2004. Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes. J. Immunol. 172:292-301. (Pubitemid 38020483)
12. Langenkamp, A., M. Messi, A. Lanzavecchia, and F. Sallusto. 2000. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 1:311-316.
13. Reis e Sousa, C. 2006. Dendritic cells in a mature age. Nat. Rev. Immunol. 6:476-483.
14. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685-711. (Pubitemid 37174545)
15. Lohr, J., B. Knoechel, E. C. Kahn, and A. K. Abbas. 2004. Role of B7 in T cell tolerance. J. Immunol. 173:5028-5035. (Pubitemid 39387785)
16. Kim, J., K. Park, H. J. Kim, J. Kim, H. A. Kim, D. Jung, H. J. Kim, H. J. Choi, S. Y. Choi, K. W. Seo, et al. 2008. Breaking of CD8+ T cell tolerance through in vivo ligation of CD40 results in inhibition of chronic graft-versus-host disease and complete donor cell engraftment. J. Immunol. 181:7380-7389.
17. Nie, Y. J., M. Y. Mok, G. C. Chan, A. W. Chan, O. U. Jin, S. Kavikondala, A. K. Lie, and C. S. Lau. 2010. Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus. Arthritis Res. Ther. 12: R91.
18. Peters, A. L., L. L. Stunz, and G. A. Bishop. 2009. CD40 and autoimmunity: the dark side of a great activator. Semin. Immunol. 21:293-300.
19. Elgueta, R., M. J. Benson, V. C. de Vries, A. Wasiuk, Y. Guo, and R. J. Noelle. 2009. Molecular mechanism and function of CD40/CD40L engagement in the immune system. Immunol. Rev. 229:152-172.
20. O'Sullivan, B., and R. Thomas. 2003. CD40 and dendritic cell function. Crit. Rev. Immunol. 23:83-107. (Pubitemid 36875475)
21. Quezada, S. A., L. Z. Jarvinen, E. F. Lind, and R. J. Noelle. 2004. CD40/CD154 interactions at the interface of tolerance and immunity. Annu. Rev. Immunol. 22:307-328. (Pubitemid 38680425)
22. Perona-Wright, G., S. J. Jenkins, R. A. O'Connor, D. Zienkiewicz, H. J. McSorley, R. M. Maizels, S. M. Anderton, and A. S. MacDonald. 2009. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J. Immunol. 182:2808-2815.
23. Knoechel, B., J. Lohr, E. Kahn, and A. K. Abbas. 2005. The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance. J. Immunol. 175:21-26. (Pubitemid 40884296)
24. Knoechel, B., J. Lohr, E. Kahn, J. A. Bluestone, and A. K. Abbas. 2005. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202:1375-1386. (Pubitemid 41668740)
25. Czerniecki, B. J., P. A. Cohen, M. Faries, S. Xu, J. G. Roros, and I. Bedrosian. 2001. Diverse functional activity of CD83+ monocyte-derived dendritic cells and the implications for cancer vaccines. Crit. Rev. Immunol. 21:157-178. (Pubitemid 32959359)