Prostaglandin E2 vaginal gel or tablets for the induction of labour at term: A randomised controlled trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 118, Issue 6, 2011, Pages 719-725

  Taher, S E ^a   Inder, J W ^a   Soltan, S A ^a   Eliahoo, J ^a   Edmonds, D K ^a   Bennett, P R ^a,b  

^a IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Gel; induction; labour; prostaglandin; tablet

Indexed keywords

OXYTOCIN; PLACEBO; PROSTAGLANDIN E2;

ADULT; AMNIOTOMY; ARTICLE; CEPHALIC PRESENTATION; CESAREAN SECTION; CONTROLLED STUDY; DELIVERY; DRUG DOSAGE FORM COMPARISON; DRUG TREATMENT FAILURE; EPIDURAL ANESTHESIA; FAILED INDUCTION; FEMALE; FETUS BLOOD SAMPLING; FETUS DISTRESS; GEL; GESTATIONAL AGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; LABOR COMPLICATION; LABOR INDUCTION; MAJOR CLINICAL STUDY; MATERNAL AGE; MATERNAL HYPERTENSION; MATERNITY WARD; MECONIUM; MULTIPLE PREGNANCY; OUTCOME ASSESSMENT; OVARY HYPERSTIMULATION; POSITION; PREGNANCY OUTCOME; PREGNANT WOMAN; PREMATURE FETUS MEMBRANE RUPTURE; PRIMIGRAVIDA; PRIORITY JOURNAL; PROLONGED PREGNANCY; RANDOMIZED CONTROLLED TRIAL; TABLET FORMULATION; TREATMENT INDICATION; TREATMENT OUTCOME; UNITED KINGDOM; UNIVERSITY HOSPITAL; UTERINE CERVIX DILATATION; UTERINE CERVIX RIPENING;

ADMINISTRATION, INTRAVAGINAL; ADULT; CESAREAN SECTION; DINOPROSTONE; FEMALE; HUMANS; LABOR, INDUCED; OBSTETRIC LABOR COMPLICATIONS; OXYTOCICS; PARITY; PREGNANCY; PREGNANCY OUTCOME; TABLETS; TERM BIRTH; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 79954627093     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2011.02901.x     Document Type: Article

References (12)

1. National Collaborating Centre for Women's and Children's Health. Induction of labour. Clinical Guideline. London: NICE press, 2008.
2. Royal College of Obstetricians and Gynaecologists; RCOG Clinical Effectiveness Support Unit. Induction of labour. Evidence-based Clinical Guideline Number 9. London: RCOG Press, 2001.
3. Kelly AJ, Cavanaugh J, Thomas J,. Vaginal prostaglandin (PGE2 and PGF2a) for Induction of labour at term. Cochrane Database Syst Rev 2003; 4: CD003101.
4. Joint Formulary Committee. British National Formulary, 54th edn. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2007.
5. Mahmood TA,. A prospective comparative study on the use of prostaglandin E2 gel (2 mg) and prostaglandin E2 tablet (3 mg) for the induction of labour in primigravid women with unfavourable cervices. Eur J Obstet Gynecol Reprod Biol 1989; 33 (2): 169-75. (Pubitemid 19286507)
6. Murray HG, Buonocore A, Hawley J,. A randomized trial of two preparations of vaginal prostaglandin for pre-induction cervical ripening. Obstet Gynecol 1995; 86 (6): 880-5. (Pubitemid 27331477)
7. Greer IA, MacLaren M, Calder AA,. Vaginal administration of PGE2 for induction of labour stimulates endogenous PGF2α production. Acta Obstet Gynecol Scand 1990; 69: 621-5.
8. Payne E, Reed MF, Cietak KA, Anderson WR, Sant-Cassia LJ,. A comparison of prostaglandin E2 vaginal tablets with vaginal gel for ripening the unfavourable cervix and induction of labour. J Obstet Gynaecol 1993; 13: 103-6. (Pubitemid 23137993)
9. Al-Sebai MAH, Manasse PR,. Induction of labour in primigravid women with an unfavourable cervix: a prospective comparative study of prostaglandin E2 vaginal tablets and gel. J Obstet Gynaecol 1993; 13: 112-3. (Pubitemid 23137996)
10. Kelly AJ, Malik S, Smith L, Kavanagh J, Thomas J,. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Cochrane Database Syst Rev 2009; 4: CD003246.
11. Van Gemund N, Scherjon S, LeCessie S, van Leeuwen JH, van Roosmalen J, Kanhai HHA,. Randomised trial comparing low dose vaginal misoprostol and dinoprostone for labour induction. BJOG 2004; 111: 42-9. (Pubitemid 38223332)
12. Pocock SJ,. When to stop a clinical trial. BMJ 1992; 305: 235-40.