Liprin-α1 regulates breast cancer cell invasion by affecting cell motility, invadopodia and extracellular matrix degradation

Oncogene

Volumn 30, Issue 15, 2011, Pages 1841-1849

  Astro, V ^a   Asperti, C ^a   Cangi, G ^a   Doglioni, C ^a   De Curtis, I ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

cell migration; invadopodia; invasion; lamellipodia; liprins

Indexed keywords

CELL PROTEIN; CORTACTIN; LIPRIN ALPHA 1; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER INVASION; CELL INVADOPODIA; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL SPREADING; DEGRADATION KINETICS; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE, TUMOR; CELL MOVEMENT; EXTRACELLULAR MATRIX; FEMALE; HUMANS;

EID: 79954613016     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.562     Document Type: Article

References (23)

1. Al-Kuraya K, Schraml P, Torhorst J, Tapia C, Zaharieva B, Novotny H et al. (2004). Prognostic relevance of gene amplifications and coamplifications in breast cancer. Cancer Res 64: 8534-8540. (Pubitemid 39552065)
2. Albiges-Rizo C, Destaing O, Fourcade B, Planus E, Block MR. (2009). Actin machinery and mechanosensitivity in invadopodia, podo-somes and focal adhesions. J Cell Sci 122: 3037-3049.
3. Artym VV, Zhang Y, Seillier-Moiseiwitsch F, Yamada KM, Mueller SC. (2006). Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res 66: 3034-3043.
4. Asperti C, Astro V, Totaro A, Paris S, De Curtis I. (2009). Liprin-alpha1 promotes cell spreading on the extracellular matrix by affecting the distribution of activated integrins. J Cell Sci 122: 3225-3232.
5. Asperti C, Pettinato E, De Curtis I. (2010). Liprin-alpha1 affects the distribution of low-affinity beta1 integrins and stabilizes their permanence at the cell surface. Exp Cell Res 316: 915-926.
6. Cao H, Orth JD, Chen J, Weller SG, Heuser JE, McNiven MA. (2003). Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol 23: 2162-2170. (Pubitemid 36278824)
7. De Curtis I. (2011). Function of liprins in cell motility. Exp Cell Res 317: 1-8.
8. Frank SR, Adelstein MR, Hansen SH. (2006). GIT2 represses Crk-and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J 25: 1848-1859.
9. Jarvinen AK, Autio R, Haapa-Paananen S, Wolf M, Saarela M, Grenman R et al. (2006). Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses. Oncogene 25: 6997-7008. (Pubitemid 44684840)
10. Katoh M, Katoh M. (2005). Comparative genomics on mammalian Fgf3-Fgf4 locus. Int J Oncol 27: 281-285.
11. Kim S, Chin K, Gray JW, Bishop JM. (2004). A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci USA 101: 16251-16256. (Pubitemid 39552831)
12. Lenter M, Uhlig H, Hamann A, Jeno P, Imhof B, Vestweber DA. (1993). A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1. Proc Natl Acad Sci USA 90: 9051-9055. (Pubitemid 23306449)
13. Nachat R, Cipolat S, Sevilla LM, Chhatriwala M, Groot KR, Watt FM. (2009). KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules. J Cell Sci 122: 4035-4041.
14. Pankov R, Endo Y, Even-Ram S, Araki M, Clark K, Cukierman E et al. (2005). A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol 170: 793-802. (Pubitemid 41242111)
15. Qiao F, Bowie JU. (2005). The many faces of SAM. Sci STKE 2005: re7.
16. Serra-Pages C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M. (1995). The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J 14: 2827-2838.
17. Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M. (1998). Liprins, a family of LAR transmembrane protein-tyrosine phos-phatase-interacting proteins. J Biol Chem 273: 15611-15620. (Pubitemid 28298175)
18. Shaw LM. (2005). Tumor cell invasion assays. Methods Mol Biol 294: 97-105.
19. Shen JC, Unoki M, Ythier D, Duperray A, Varticovski L, Kumamoto K et al. (2007). Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. Cancer Res 67: 2552-2558. (Pubitemid 46548940)
20. Spangler SA, Hoogenraad CC. (2007). Liprin-alpha proteins: scaffold molecules for synapse maturation. Biochem Soc Trans 35: 1278-1282. (Pubitemid 350206478)
21. Tan KD, Zhu Y, Tan HK, Rajasegaran V, Aggarwal A, Wu J et al. (2008). Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma. Genes Chromosomes Cancer 47: 353-362. (Pubitemid 351323765)
22. Totaro A, Paris S, Asperti C, De Curtis I. (2007). Identification of an intramolecular interaction important for the regulation of GIT1 functions. Mol Biol Cell 18: 5124-5138. (Pubitemid 350246711)
23. Weaver AM. (2008). Invadopodia. Curr Biol 18: R362-R364. (Pubitemid 351626587)