Pharmacological intervention against bubble-induced platelet aggregation in a rat model of decompression sickness

Journal of Applied Physiology

Volumn 110, Issue 3, 2011, Pages 724-729

  Pontier, Jean Michel ^a,b,c,e   VallÉe, Nicolas ^b   Ignatescu, Mihaela ^d   Bourdon, Lionel ^b  

^a Centre D'expertise Plongée pour la Marine Nationale   (France)

^b ERRSO   (France)

^c UMR MD 2 Physiologie et Physiopathologie en Condition d'Oxygénation Extrême   (France)

^d WHIPPS CROSS UNIVERSITY HOSPITAL   (United Kingdom)

^e French Navy Diving School   (France)

Author keywords

Bubble formation; Platelet activation

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; FIBRINOLYTIC AGENT;

AIR EMBOLISM; ANIMAL; ARTICLE; COMPARATIVE STUDY; DECOMPRESSION SICKNESS; DISEASE MODEL; DRUG EFFECT; HUMAN; MALE; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; THROMBOCYTE AGGREGATION; TREATMENT OUTCOME;

ANIMALS; ANTICOAGULANTS; DECOMPRESSION SICKNESS; DISEASE MODELS, ANIMAL; EMBOLISM, AIR; FIBRINOLYTIC AGENTS; HUMANS; MALE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 79954611583     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00230.2010     Document Type: Article

References (37)

1. Bennet PB, Brock AJ. Action of selected drugs on decompression sickness in rats. Aerospace Med 40: 607-610, 1969.
2. Bove AA. The basis for drug therapy in decompression sickness. Undersea Biomed Res 9: 91-111, 1982. (Pubitemid 12050594)
3. Broome JR. Association of CNS hemorrhage with failure to respond to recompression treatment-implications for management of refractory cases of decompression illness. In: Undersea and Hyperbaric Medical Society, edited by Moon RE and Sheffield PJ, 1996, p. 364-373.
4. Broussolle B, Hyacinthe R, Mainart G, Stoltz JF. Use of anti platelet aggregation substances in the treatment of decompression accidents in the rats. J Physiol 67: 334-344, 1973.
5. Butler BD, Hills BA. Transpulmonary passage of venous air emboli. J Appl Physiol 59: 543-547, 1985. (Pubitemid 15248974)
6. Clay JR. Histopathologiy of experimental decompression sickness. Aerospace Med 34: 1107-1110, 1963.
7. Gachet C. ADP receptors of platelets and their inhibition. Thromb Haemost 86: 222-232, 2001. (Pubitemid 32663953)
8. Geller F. Uber die Blutgerinung unter dem Einfluss von Gasen (Coagulation and circulating gas bubble). Arch Gesamte Physiol Menschen Tiere 244: 687-695, 1941.
9. Giry P, Porlier G, Eastman D, Radomski MW. Dive-induced modifications in platelet kinetics in rats. Undersea Biomed Res 4: 147-157, 1977. (Pubitemid 8125332)
10. Hallenbeck JM, Bove AA, Moquin RB. Accelerated coagulation of whole blood and cell-free plasma by bubbling in vitro. Aerospace Med 44: 712-714, 1973.
11. Holland HA. Discussion of disseminated intravascular coagulation in decompression sickness. Report 585. Groton, CT: US Naval Submarine Medical Center, 1969.
12. Inwood BM. Experimental evidence in support of the hypothesis that intravascular bubbles activate the hemostatic process. In: Symposium of Blood-Bubble Interactions in Decompression Sickness DCIEM Rep N° 73-CP-960: 171-200, 1973.
13. Jacey MJ, Heyder E, Williamson RA. Biochemistry and haematology of decompression sickness: A case report. Aviat Space Environ Med 47: 657-661, 1976.
14. Jacobs MH, Stewart DR. Observations on the blood of albino rats following rapid decompression. US National Research Council Comm. Aviat Med 1-5, 1942.
15. Laborit H, Barthelemy L, Perrimond-Trouchet R. Action of heparin in the treatment of complications of decompression. Agressologie 2: 229-236, 1961.
16. Lillo RS, Parker EC. Mixed-gas model for predicting decompression sickness in rats. J Appl Physiol 89: 2107-2116, 2000.
17. Michibayashi T. Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathways. J Atheroscler Thromb 12: 154-162, 2005.
18. Montcalm-Smith EA, Fahlman A, Kayar SR. Pharmacological interventions to decompression sickness in rats: Comparison of five agents. Aviat Space Environ Med 79: 7-13, 2008.
19. Moon RE, Fawcett TA, Exposito AJ. Platelet count in deep saturation diving. Undersea Biomed Res 19: 279-286, 1992.
20. Nishi RY. Doppler evaluation of decompression tables. In: Man in the Sea, edited by Lin YC, Shida KK. Honolulu: University of Hawaii Press, 1990, p. 297-316.
21. Nossum V, Koten S, Brubakk AO. Endothelial damage by bubbles in the pulmonary artery of the pig. Undersea Hyperb Med 26: 1-8, 1999.
22. Olszanski R, Sicko Z, Baj Z. Effect of nitrox saturation diving upon platelet hemostasis. Bull Inst Marit Trop Med Gdynia 41: 59-62, 1990.
23. Philp RB. The ameliorative effects of heparine and depolymerized hyaluronate on decompression sickness in rats. Can J Physiol Pharmacol 42: 819-829, 1964.
24. Philp RB. A review of blood changes associated with compressiondecompression: Relationship to decompression sickness. Undersea Biomed Res 1: 117-150, 1974.
25. Philp RB, Bennet PB, Andersen JC, Fields GN. Effects of aspirin and dipyridamole on platelet function, hematology and blood chemistry of saturation divers. Undersea Biomed Res 6: 127-146, 1979. (Pubitemid 9232592)
26. Philp RB, Inwood MJ, Warren BA. Interactions between gas bubbles and components of the blood: Implications in decompression sickness. Aerospace Med 43: 946-953, 1972.
27. Philp RB, Schacham P, Gowdey CW. Involvement of platelets and microthrombi in experimental decompression sickness: Similarities with disseminated intravascular coagulation. Aerospace Med 41: 1358-1361, 1971.
28. Pontier JM, Blatteau JE, Vallée N. Blood platelet count and severity of decompression sickness in rats after a provocative dive. Aviat Space Environ Med 79: 761-764, 2008.
29. Pontier JM, Jimenez C, Blatteau JE. Blood platelet count and bubble formation after a dive to 30 msw for 30 min. Aviat Space Environ Med 79: 1-4, 2008.
30. Pontier JM, Vallée N, Bourdon L. Bubble-induced platelet aggregation in a rat model of decompression sickness. J Appl Physiol 107: 1825-1829, 2009.
31. Popovic P, Popovic V, Honeycutt C. Levodopa and aspirin pretreatment beneficial in experimental decompression sickness. Proc Soc Exp Biol Med 169: 140-143, 1982. (Pubitemid 12121075)
32. Reeves E, Workman RD. Use of heparin for the therapeutic-prophylactic treatment of decompression sickness. Aerospace Med 42: 20-23, 1971.
33. Savi P, Nurden P, Nurden AT, Levy-Toledano S, Herbert JM. Clopidogrel: A review of its mechanism of action. Platelets 9: 251-255, 1998. (Pubitemid 28312689)
34. Tanoue K, Mano Y, Kuroiwa K. Consumption of platelets in decompression sickness of rabbits. J Appl Physiol 62: 1772-1779, 1987. (Pubitemid 17108119)
35. Thorsen T, Dalen H, Bjerkvig R, Holmsen H. Transmission and scanning electron microscopy of N2 microbubble-activated human platelets in vitro. Undersea Biomed Res 14: 45-58, 1987. (Pubitemid 17003139)
36. Thorsen T, Ovstedal T, Vereide A, Holmsen H. Effects of platelet antagonist on the reduction in platelet density caused by microbubbles in vitro. Undersea Biomed Res 13: 289-303, 1986. (Pubitemid 17207022)
37. Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res 110: 255-258, 2003. (Pubitemid 37329821)