Pooled analysis of brain activity in irritable bowel syndrome and controls during rectal balloon distension

Neurogastroenterology and Motility

Volumn 23, Issue 4, 2011, Pages

  Sheehan, J ^a   Gaman, A ^a   Vangel, M ^a   Kuo, B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brain imaging; Colo rectal stimulation; Irritable bowel syndrome; Pooled analysis

Indexed keywords

ANTERIOR CINGULATE; ARTICLE; BRAIN RADIOGRAPHY; ELECTROENCEPHALOGRAM; HUMAN; IRRITABLE COLON; POSTERIOR CINGULATE; PREFRONTAL CORTEX; PRIORITY JOURNAL; THALAMUS;

BALLOON DILATION; BRAIN; HUMANS; IRRITABLE BOWEL SYNDROME; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; RECTUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 79954610817     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2010.01635.x     Document Type: Article

References (54)

1. National Institute of Health. Irritable bowel syndrome, 2007. Available at: (cited 3 August 2009).
2. Adam B, Liebregts T, Gschossmann JM, et al. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Pain 2006; 123: 179-86.
3. Al-Chaer ED, Kawasaki M, Pasricha PJ. A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 2000; 119: 1276-85.
4. Andresen V, Bach DR, Poellinger A, et al. Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome. Neurogastroenterol Motil 2005; 17: 827-37.
5. Berman SM, Naliboff BD, Chang L, et al. Enhanced preattentive central nervous system reactivity in irritable bowel syndrome. Am J Gastroenterol 2002; 97: 2791-7.
6. Berman SM, Naliboff BD, Suyenobu B, et al. Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome. J Neurosci 2008; 28: 349-59.
7. Bernstein CN, Frankenstein UN, Rawsthorne P, Pitz M, Summers R, McIntyre MC. Cortical mapping of visceral pain in patients with GI disorders using functional magnetic resonance imaging. Am J Gastroenterol 2002; 97: 319-27.
8. Blomhoff S, Spetalen S, Jacobsen MB, Vatn M, Malt UF. Intestinal reactivity to words with emotional content and brain information processing in irritable bowel syndrome. Dig Dis Sci 2000; 45: 1160-5.
9. Bonaz B, Baciu M, Papillon E, et al. Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study. Am J Gastroenterol 2002; 97: 654-61.
10. Chang L, Berman S, Mayer EA, et al. Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia. Am J Gastroenterol 2003; 98: 1354-61.
11. Czimmer J, Suto G, Kiraly A, Mozsik G. Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome. J Physiol Paris 2001; 95: 153-6.
12. Dickhaus B, Mayer EA, Firooz N, et al. Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. Am J Gastroenterol 2003; 98: 135-43.
13. Drossman DA, Ringel Y, Vogt BA, et al. Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome. Gastroenterology 2003; 124: 754-61.
14. Evans PR, Kellow JE. Physiological modulation of jejunal sensitivity in health and in irritable bowel syndrome. Am J Gastroenterol 1998; 93: 2191-6.
15. Fukudo S, Kanazawa M, Kano M, et al. Exaggerated motility of the descending colon with repetitive distention of the sigmoid colon in patients with irritable bowel syndrome. J Gastroenterol 2002; 37(Suppl. 14): 145-50.
16. Hamaguchi T, Kano M, Rikimaru H, et al. Brain activity during distention of the descending colon in humans. Neurogastroenterol Motil 2004; 16: 299-309.
17. Kanazawa M, Palsson OS, Thiwan SI, et al. Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits. Am J Gastroenterol 2008; 103: 2550-61.
18. Khalif IL, Quigley EM, Makarchuk PA, Golovenko OV, Podmarenkova LF, Dzhanayev YA. Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). J Gastrointestin Liver Dis 2009; 18: 17-22.
19. Kwan CL, Diamant NE, Pope G, Mikula K, Mikulis DJ, Davis KD. Abnormal forebrain activity in functional bowel disorder patients with chronic pain. Neurology 2005; 65: 1268-77.
20. Lackner JM, Lou Coad M, Mertz HR, et al. Cognitive therapy for irritable bowel syndrome is associated with reduced limbic activity, GI symptoms, and anxiety. Behav Res Ther 2006; 44: 621-38.
21. Lawal A, Kern M, Sidhu H, Hofmann C, Shaker R. Novel evidence for hypersensitivity of visceral sensory neural circuitry in irritable bowel syndrome patients. Gastroenterology 2006; 130: 26-33.
22. Lembo T, Munakata J, Mertz H, et al. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994; 107: 1686-96.
23. Lembo T, Munakata J, Naliboff B, Fullerton S, Mayer EA. Sigmoid afferent mechanisms in patients with irritable bowel syndrome. Dig Dis Sci 1997; 42: 1112-20.
24. Lind CD. Motility disorders in the irritable bowel syndrome. Gastroenterol Clin North Am 1991; 20: 279-95.
25. Mayer EA, Berman S, Suyenobu B, et al. Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis. Pain 2005; 115: 398-409.
26. Mertz H, Morgan V, Tanner G, et al. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distension. Gastroenterology 2000; 118: 842-8.
27. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995; 109: 40-52.
28. Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 2005; 54: 601-7.
29. Naliboff BD, Berman S, Chang L, et al. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 2003; 124: 1738-47.
30. Naliboff BD, Berman S, Suyenobu B, et al. Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients. Gastroenterology 2006; 131: 352-65.
31. Naliboff BD, Derbyshire SW, Munakata J, et al. Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation. Psychosom Med 2001; 63: 365-75.
32. Nozu T, Kudaira M. Corticotropin-releasing factor induces rectal hypersensitivity after repetitive painful rectal distention in healthy humans. J Gastroenterol 2006; 41: 740-4.
33. Okano S, Ikeura Y, Inatomi N. Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits. J Pharmacol Exp Ther 2002; 300: 925-31.
34. Price DD, Craggs J, Nicholas Verne G, Perlstein WM, Robinson ME. Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients. Pain 2007; 127: 63-72.
35. Ringel Y, Drossman DA, Leserman JL, et al. Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an FMRI study. Gastroenterology 2008; 134: 396-404.
36. Ringel Y, Drossman DA, Turkington TG, et al. Regional brain activation in response to rectal distension in patients with irritable bowel syndrome. Dig Dis Sci 2003; 48: 1774-81.
37. Sidhu H, Kern M, Shaker R. Absence of increasing cortical fMRI activity volume in response to increasing visceral stimulation in IBS patients. Am J Physiol Gastrointest Liver Physiol 2004; 287: G425-35.
38. Silverman DH, Munakata JA, Ennes H, Mandelkern MA, Hoh CK, Mayer EA. Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology 1997; 112: 64-72.
39. Song GH, Venkatraman V, Ho KY, Chee MW, Yeoh KG, Wilder-Smith CH. Cortical effects of anticipation and endogenous modulation of visceral pain assessed by functional brain MRI in irritable bowel syndrome patients and healthy controls. Pain 2006; 126: 79-90.
40. Verne GN, Himes NC, Robinson ME, et al. Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome. Pain 2003; 103: 99-110.
41. Wang W, Pan G, Qian J. Effect of psychological factors on visceral sensation of patients with irritable bowel syndrome. Zhonghua Yi Xue Za Zhi 2002; 82: 308-11.
42. Wilder-Smith CH, Schindler D, Lovblad K, Redmond SM, Nirkko A. Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls. Gut 2004; 53: 1595-601.
43. Yuan YZ, Tao RJ, Xu B, et al. Functional brain imaging in irritable bowel syndrome with rectal balloon-distention by using fMRI. World J Gastroenterol 2003; 9: 1356-60.
44. Zuo XL, Li YQ, Huang KM, et al. Alterations in cerebral potentials evoked by rectal distention and drinking ice water in patients with irritable bowel syndrome. J Gastroenterol Hepatol 2006; 21: 1844-9.
45. Zuo XL, Li YQ, Shi L, et al. Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome. J Gastroenterol 2006; 41: 311-7.
46. Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER. Affective disturbances modulate the neural processing of visceral pain stimuli in irritable bowel syndrome: an fMRI Study. Gut 2010; 59: 489-95.
47. Hall GB, Kamath MV, Collins S, et al. Heightened central affective response to visceral sensations of pain and discomfort in IBS. Neurogastroenterol Motil 2010; 22: 276-E80.
48. Lotze M, Wietek B, Birbaumer N, Ehrhardt J, Grodd W, Enck P. Cerebral activation during anal and rectal stimulation. Neuroimage 2001; 14: 1027-34.
49. Mayer EA, Aziz Q, Coen S, et al. Brain imaging approaches to the study of functional GI disorders: a Rome Working Team Report. Neurogastroenterol Motil 2009; 21: 579-96.
50. Knowles CH, Aziz Q. Basic and clinical aspects of gastrointestinal pain. Pain 2009; 141: 191-209.
51. Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in clinical research. Lancet 1991; 337: 867-72.
52. Huston P, Moher D. Redundancy, disaggregation, and the integrity of medical research. Lancet 1996; 347: 1024-6.
53. Tillisch K, Mayer EA, Labus JS. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology 2010; doi: 10.1053/j.gastro.2010.07.053.
54. Mueller SG, Weiner MW, Thal LJ, et al. The Alzheimer's disease neuroimaging initiative. Neuroimaging Clin N Am 2005; 15: 869-77, xi-xii.