The association between verbal memory, processing speed, negative symptoms and functional capacity in schizophrenia

Psychiatry Research

Volumn 187, Issue 3, 2011, Pages 329-334

  McDowd, Joan ^a   Tang, Tze Chun ^b   Tsai, Pei Chun ^b   Wang, Shing Yaw ^b   Su, Chwen Yng ^c  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cognition; Functional outcome; Mediation analysis; Symptoms

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; NEUROLEPTIC AGENT;

ADOLESCENT; ADULT; ARTICLE; COGNITION; DISEASE ASSOCIATION; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL STATUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL CAPACITY; MENTAL PERFORMANCE; MENTAL TASK; MULTIPLE REGRESSION; NEGATIVE SYNDROME; PREDICTION; PRIORITY JOURNAL; SCHIZOPHRENIA; STATISTICAL MODEL; TASK PERFORMANCE; VERBAL MEMORY;

ACTIVITIES OF DAILY LIVING; ADOLESCENT; ADULT; COGNITION DISORDERS; FACTOR ANALYSIS, STATISTICAL; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; MODELS, PSYCHOLOGICAL; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; VERBAL LEARNING; YOUNG ADULT;

EID: 79954605250     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2011.01.017     Document Type: Article

References (45)

1. Diagnostic and Statistical Manual of Mental Disorder. (DSM IV) 1994, American Psychiatric Association, American Psychiatry Press, Washington, DC. 4th Edition.
2. Bachman P., Reichenberg A., Rice P., Woolsey M., Chaves O., Martinez D., Maples N., Velligan D.I., Glahn D.C. Deconstructing processing speed deficits in schizophrenia: application of a parametric digit symbol coding test. Schizophrenia Research 2010, 118:6-11.
3. Bell M.D., Mishara A.L. Does negative symptom change relate to neurocognitive change in schizophrenia? Implications for targeted treatments. Schizophrenia Research 2006, 81:17-27.
4. Bowie C.R., Leung W.W., Reichenberg A., McClure M.M., Patterson T.L., Heaton R.K., Harvey P.D. Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures. Biological Psychiatry 2008, 63:505-511.
5. Chu T.F. Activities of Daily Living Rating Scale-Second Edition 1993, Caleb Pharmaceuticals, Taipei.
6. Chu T.F. Chu's Attention and Processing Speed Test 1997, Caleb Pharmaceuticals, Taipei.
7. Cirillo M.A., Seidman L.J. Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms. Neuropsychology Review 2003, 13:43-77.
8. D' Elia L.F., Satz P., Uchiyama C.L., White T. Color Trails Test: Professional Manual 1996, Psychological Assessment Resources, Odesa.
9. Dickinson D., Coursey R.D. Independence and overlap among neurocognitive correlates of community functioning in schizophrenia. Schizophrenia Research 2002, 56:161-170.
10. Dickinson D., Ramsey M.E., Gold J.M. Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Archives of General Psychiatry 2007, 64:532-542.
11. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured clinical interview for DSM-IV axis I disorders 1996, American Psychiatric Association, Washington, DC.
12. Fujii D.E., Wylie A.M. Neurocognition and community outcome in schizophrenia: long-term predictive validity. Schizophrenia Research 2003, 59:219-223.
13. Green M.F. What are the functional consequences of neurocognitive deficits in schizophrenia?. American Journal of Psychiatry 1996, 153:321-330.
14. Green M.F., Kern R.S., Braff D.L., Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?. Schizophrenia Bulletin 2000, 26:119-136.
15. Green M.F., Kern R.S., Heaton R.K. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophrenia Research 2004, 72:41-51.
16. Greenwood K.E., Landau S., Wykes T. Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy. Schizophrenia Bulletin 2005, 31:910-921.
17. Hai J.F., Anderson R.E., Tatham R.L., Black W.C. Multivariate Data Analysis 1998, Prentice-Hall, New Jersey.
18. Heinrichs R.W., Ammari N., Miles A., McDermid Vaz.S., Chopov B. Psychopathology and cognition in divergent functional outcomes in schizophrenia. Schizophrenia Research 2009, 109:46-51.
19. Hu L., Bentler P.M. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Structural Equation Modeling 1999, 6:1-55.
20. Joy S., Kaplan E., Fein D. Speed and memory in the WAIS-III Digit Symbol-Coding subtest across the adult lifespan. Archives of Clinical Neuropsychology 2004, 19:759-767.
21. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 1987, 13:262-276.
22. Keefe R.S.E., Eesley C.E. Neurocognitive impairment. Textbook of Schizophrenia 2006, 252. American Psychiatric Publishing, Washington, DC. J.A. Lieberman, T.S. Stroup, D.O. Perkins (Eds.).
23. Leifker F.R., Bowie C.R., Harvey P.D. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophrenia Research 2009, 115:82-87.
24. Lipkovich I.A., Deberdt W., Csernansky J.G., Sabbe B., Keefe R.S., Kollack-Walker S. Relationships among neurocognition, symptoms and functioning in patients with schizophrenia: a path-analytic approach for associations at baseline and following 24weeks of antipsychotic drug therapy. BMC Psychiatry 2009, 9:44.
25. MacKinnon D.P. Introduction to Statistical Mediation Analysis 2008, Lawrence Erlbaum Associates, Mahwah, NJ.
26. McClure M.M., Bowie C.R., Patterson T.L., Heaton R.K., Weaver C., Anderson H., Harvey P.D. Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: evidence for specificity of relationships?. Schizophrenia Research 2007, 89:330-338.
27. Milev P., Ho B.C., Arndt S., Andreasen N.C. Predictive values of neurocognition and negative symptoms on functional outcome in schizophrenia: a longitudinal first-episode study with 7-year follow-up. American Journal of Psychiatry 2005, 162:495-506.
28. Mohamed S., Rosenheck R., Swartz M., Stroup S., Lieberman J.A., Keefe R.S. Relationship of cognition and psychopathology to functional impairment in schizophrenia. American Journal of Psychiatry 2008, 165:978-987.
29. Muthén B.O., Muthén L.K. Mplus User's Guide 2007, Muthen & Muthen, Los Angeles. 5th Edition.
30. Norman R.M., Malla A.K., Cortese L., Cheng S., Diaz K., McIntosh E., McLean T.S., Rickwood A., Voruganti L.P. Symptoms and cognition as predictors of community functioning: a prospective analysis. American Journal of Psychiatry 1999, 156:400-405.
31. Ojeda N., Peña J., Sánchez P., Elizagárate E., Ezcurra J. Processing speed mediates the relationship between verbal memory, verbal fluency, and functional outcome in chronic schizophrenia. Schizophrenia Research 2008, 101:225-233.
32. O'Leary D.S., Flaum M., Kesler M.L., Flashman L.A., Arndt S., Andreasen N.C. Cognitive correlates of the negative, disorganized, and psychotic symptom dimensions of schizophrenia. Journal of Neuropsychiatry and Clinical Neurosciences 2000, 12:4-15.
33. Preacher K.J., Hayes A.F. Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavioral Research Methods 2008, 40:879-891.
34. Puig O., Penadés R., Gastó C., Catalán R., Torres A., Salamero M. Verbal memory, negative symptomatology and prediction of psychosocial functioning in schizophrenia. Psychiatry Research 2008, 158:11-17.
35. Raykov T., Marcoulides G.A. Can there be infinitely many models equivalent to a given covariance structure model?. Structural Equation Modeling 2001, 8:142-149.
36. Rempfer M.V., Hamera E.K., Brown C.E., Cromwell R.L. The relations between cognition and the independent living skill of shopping in people with schizophrenia. Psychiatry Research 2003, 117:103-112.
37. Revheim N., Schechter I., Kim D., Silipo G., Allingham B., Butler P., Javitt D.C. Neurocognitive and symptom correlates of daily problem-solving skills in schizophrenia. Schizophrenia Research 2006, 83:237-245.
38. Sánchez P., Ojeda N., Peña J., Elizagárate E., Yoller A.B., Gutiérrez M., Ezcurra J. Predictors of longitudinal changes in schizophrenia: the role of processing speed. Journal of Clinical Psychiatry 2009, 70:888-896.
39. Shamsi S., Lau A., Lencz T., Burdick K.E., Derosse P., Brenner R., Lindenmayer J.P., Malhotra A.K. Cognitive and symptomatic predictors of functional disability in schizophrenia. Schizophrenia Research. 2011, 126:257-264.
40. Tan M.Y. Validity and reliability of the Hooper Visual Organization Test in schizophrenia 2009, Unpublished master's thesis, Kaohsiung Medical University, Taiwan.
41. Velligan D.I., Mahurin R.K., Diamond P.L., Hazleton B.C., Eckert S.L., Miller A.L. The functional significance of symptomatology and cognitive function in schizophrenia. Schizophrenia Research 1997, 25:21-31.
42. Ventura J., Hellemann G.S., Thames A.D., Koellner V., Nuechterlein K.H. Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophrenia Research 2009, 113:189-199.
43. Villalta-Gil V., Vilaplana M., Ochoa S., Haro J.M., Dolz M., Usall J., Cervilla J. Neurocognitive performance and negative symptoms: are they equal in explaining disability in schizophrenia outpatients?. Schizophrenia Research 2006, 87:246-253. NEDENA Group.
44. Wechsler D. Wechsler Adult Intelligence Scale-III 1993, Psychology Corporation, San Antonio, TX.
45. Wechsler D. Wechsler Memory Scale-Third Edition (WMS-III) 1997, Harcourt Assessment, San Antonio, TX.