Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves

Journal of Analytical Toxicology

Volumn 35, Issue 4, 2011, Pages 238-241

  Persico, Andrea ^a   Bacis, Giuseppe ^b   Uberti, Francesca ^a   Panzeri, Claudia ^b   di Lorenzo, Chiara ^a   Moro, Enzo ^a   Restani, Patrizia ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Bergamo Poison Control Center   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

10 DEACETHYLBACCATINE; 3,5 DIMETHOXYPHENOL; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CASE REPORT; CONTROLLED STUDY; HEART ARRHYTHMIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOTENSION; MALE; PLANT INTOXICATION; PLANT LEAF; SUICIDE ATTEMPT; TAXUS BACCATA; URINALYSIS; URINE LEVEL;

CONIFEROPHYTA; TAXUS; TAXUS BACCATA;

EID: 79954595715     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/anatox/35.4.238     Document Type: Article

References (12)

1. C.R. Wilson, J. Sauer, and S.B. Hooser. Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids. Toxicon 39: 175-185 (2001).
2. J.D. Weaver and D.L. Brown. Incubation of european yew (Taxus baccata) with white-tailed deer (Odocoilesu virginianus) rumen fluid reduces taxine A concentrations. Vet. Hum. Toxicol. 46: 300-302 (2004).
3. K. Handeland. Acute yew (Taxus) poisoning in moose (Alces alces). Toxicon 52: 829-832 (2008).
4. C. Panzeri, G. Bacis, F. Ferri, G. Rinaldi, A. Persico, F. Uberti, and P. Restani. Extracorporeal life support in a severe Taxus baccata poisoning. Clin. Toxicol. 48: 463-465 (2010).
5. R. Feldman, J.M.Szajewski, J. Chrobak, and Z.M. Liberek. Four cases of self-poisoning with yew leaves decoction. Vet. Hum. Toxicol. 29: 72 (1987).
6. J. Pietsch, K. Schulz, U. Schmidt, H. Andresen, B. Schwarze, and J. Dressler. A comparative study of five fatal cases of Taxus poisoning. Int. J. Legal Med. 121: 417-422 (2007).
7. L.E. Sinn and J.F. Porterfield. Fatal taxine poisoning from yew leaf ingestion. J. Forensic Sci. 36: 599-601 (1991).
8. G. Van Ingen, R. Visser, H. Peltenburg, A.M. Van Der Art, and M.Voortman. Sudden unexpected death due to Taxus poisoning. A report of four cases, with review of the literature. Forensic Sci. Int. 56: 81-87 (1992).
9. B. Yersin, J.G. Frey, M.D. Schaller, P. Nicod, and C. Perret. Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann. Emerg. Med. 16: 1396-1397 (1987).
10. Medical Toxicology, 3rd ed., R.C. Dart, Ed. LippincottWilliams & Wilkins, Philadelphia, PA, 2004, p 1667.
11. R. Froldi, P.F. Croci, L. Dell'Acqua, F. Farè, G. Tassoni, and V. Gambaro. Preliminary gas chromatography with mass spectrometry determination of 3,5-dimethoxyphenol in biological specimens as evidence of Taxus poisoning. J. Anal. Toxicol. 34: 53-56 (2010).
12. R.W. Miller. A brief survey of Taxus alkaloids and other taxane derivatives. J. Nat. Prod. 43: 425-437 (1980).