Crystal structure of human FAF1 UBX domain reveals a novel FcisP touch-turn motif in p97/VCP-binding region

Biochemical and Biophysical Research Communications

Volumn 407, Issue 3, 2011, Pages 531-534

  Kang, Wonchull ^a   Yang, Jin Kuk ^a  

^a Soongsil University   (South Korea)

Author keywords

Grasp fold; Fas associated factor 1; P97; Touch turn motif; UBX domain

Indexed keywords

PROTEIN P97; TUMOR SUPPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN FAF1; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; UBX PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 79954592679     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.052     Document Type: Article

References (27)

1. Vij N. AAA ATPase p97/VCP: cellular functions, disease and therapeutic potential. J. Cell. Mol. Med. 2008, 12:2511-2518.
2. Dreveny I., Pye V.E., Beuron F., Briggs L.C., Isaacson R.L., Matthews S.J., McKeown C., Yuan X., Zhang X., Freemont P.S. P97 and close encounters of every kind: a brief review. Biochem. Soc. Trans. 2004, 32:715-720.
3. Yeung H.O., Kloppsteck P., Niwa H., Isaacson R.L., Matthews S., Zhang X., Freemont P.S. Insights into adaptor binding to the AAA protein p97. Biochem. Soc. Trans. 2008, 36:62-67.
4. Song E.J., Yim S.H., Kim E., Kim N.S., Lee K.J. Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway. Mol. Cell. Biol. 2005, 25:2511-2524.
5. Yuan X., Shaw A., Zhang X., Kondo H., Lally J., Freemont P.S., Matthews S. Solution structure and interaction surface of the C-terminal domain from p47: a major p97-cofactor involved in SNARE disassembly. J. Mol. Biol. 2001, 311:255-263.
6. McNeill H., Knebel A., Arthur J.S., Cuenda A., Cohen P. A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem. J. 2004, 384:391-400.
7. Alexandru G., Graumann J., Smith G.T., Kolawa N.J., Fang R., Deshaies R.J. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell 2008, 134:804-816.
8. Schuberth C., Buchberger A. UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97. Cell. Mol. Life Sci. 2008, 65:2360-2371.
9. Buchberger A., Howard M.J., Proctor M., Bycroft M. The UBX domain: a widespread ubiquitin-like module. J. Mol. Biol. 2001, 307:17-24.
10. Dreveny I., Kondo H., Uchiyama K., Shaw A., Zhang X., Freemont P.S. Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47. EMBO J. 2004, 23:1030-1039.
11. Chu K., Niu X., Williams L.T. A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis. Proc. Natl. Acad. Sci. USA 1995, 92:11894-11898.
12. Ryu S.W., Chae S.K., Lee K.J., Kim E. Identification and characterization of human Fas associated factor 1, hFAF1. Biochem. Biophys. Res. Commun. 1999, 262:388-394.
13. Ryu S.W., Lee S.J., Park M.Y., Jun J.I., Jung Y.K., Kim E. Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. J. Biol. Chem. 2003, 278:24003-24010.
14. Park M.Y., Moon J.H., Lee K.S., Choi H.I., Chung J., Hong H.J., Kim E. FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. J. Biol. Chem. 2007, 282:27572-27577.
15. Park M.Y., Jang H.D., Lee S.Y., Lee K.J., Kim E. Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA (p65) subunit of NF-kappaB. J. Biol. Chem. 2004, 279:2544-2549.
16. Menges C.W., Altomare D.A., Testa J.R. FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis. Cell Cycle 2009, 8:2528-2534.
17. Kang W., Shin H.Y., Yang J.K. Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain. Acta Cryst. 2010, F66:211-213.
18. McCoy A.J., Grosse-Kunstleve R.W., Adams P.D., Winn M.D., Storoni L.C., Read R.J. Phaser crystallographic software. J. Appl. Cryst. 2007, 40:658-674.
19. Collaborative Computational Project Number 4, The CCP4 suite: programs for protein crystallography, Acta Cryst. D50 (1994) 760-763.
20. Emsley P., Cowtan K. Coot: model-building tools for molecular graphics. Acta Cryst. 2004, D60:2126-2132.
21. Vagin A.A., Steiner R.A., Lebedev A.A., Potterton L., McNicholas S., Long F., Murshudov G.N. REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use. Acta Cryst. 2004, D60:2184-2195.
22. Brunger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., Read R.J., Rice L.M., Simonson T., Warren G.L. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Cryst. 1998, D54:905-921.
23. Madsen L., Andersen K.M., Prag S., Moos T., Semple C.A., Seeger M., Hartmann-Petersen R. Ubxd1 is a novel co-factor of the human p97 ATPase. Int. J. Biochem. Cell Biol. 2008, 40:2927-2942.
24. Richardson J.S. The anatomy and taxonomy of protein structure. Adv. Protein Chem. 1981, 34:167-339.
25. Koch O., Klebe G. Turns revisited: a uniform and comprehensive classification of normal, open, and reverse turn families minimizing unassigned random chain portions. Proteins 2009, 74:353-367.
26. Chou K.C., Blinn J.R. Classification and prediction of beta-turn types. J. Protein Chem. 1997, 16:575-595.
27. Videau L.L., Arendall W.B., Richardson J.S. The cis-Pro touch-turn: a rare motif preferred at functional sites. Proteins 2004, 56:298-309.