Heterogeneous stock rat: A unique animal model for mapping genes influencing bone fragility

Bone

Volumn 48, Issue 5, 2011, Pages 1169-1177

  Alam, Imranul ^a   Koller, Daniel L ^a   Sun, Qiwei ^a   Roeder, Ryan K ^b   Cañete, Toni ^d   Blázquez, Gloria ^d   López Aumatell, Regina ^c   Martínez Membrives, Esther ^d   Vicens Costa, Elia ^d   Mont, Carme ^d   Díaz, Sira ^d   Tobeña, Adolf ^d   Fernández Teruel, Alberto ^d   Whitley, Adam ^c   Strid, Pernilla ^e   Diez, Margarita ^e   Johannesson, Martina ^c   Flint, Jonathan ^c   Econs, Michael J ^a   Turner, Charles H ^a   Foroud, Tatiana ^a   more..

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Notre Dame   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INSTITUT DE NEUROCIÈNCIES   (Spain)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bone density; Bone strength; Genetics; Heterogeneous stock rat; Osteoporosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE FRAGILITY; BONE STRENGTH; CONTROLLED STUDY; FEMALE; FEMUR; FEMUR NECK; GENE IDENTIFICATION; GENE MAPPING; GENE SEGREGATION; GENETIC VARIABILITY; HERITABILITY; INBRED STRAIN; LUMBAR SPINE; MALE; NONHUMAN; PHENOTYPIC VARIATION; PLEIOTROPY; RAT;

ANIMALS; BIOMECHANICS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; CHROMOSOME MAPPING; FEMALE; FEMUR; FEMUR NECK; GENETIC PLEIOTROPY; INHERITANCE PATTERNS; LUMBAR VERTEBRAE; MALE; MODELS, ANIMAL; ORGAN SIZE; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED STRAINS; SEX CHARACTERISTICS;

EID: 79954584232     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.02.009     Document Type: Article

References (33)

1. Kanis J.A., Melton L.J., Christiansen C., Johnston C.C., Khaltaev N. The diagnosis of osteoporosis. J. Bone Miner. Res. 1994, 9:1137-1141.
2. Cummings S.R., Black D.M., Nevitt M.C., Browner W., Cauley J., Ensrud K., et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet 1993, 341:72-75.
3. Faulkner K.G., Cummings S.R., Black D., Palermo L., Gluer C.C., Genant H.K. Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J. Bone Miner. Res. 1993, 8:1211-1217.
4. Peacock M., Turner C.H., Liu G., Manatunga A.K., Timmerman L., Johnston C.C. Better discrimination of hip fracture using bone density, geometry and architecture. Osteoporos. Int. 1995, 5:167-173.
5. Arden N.K., Baker J., Hogg C., Bann K., Spector T.D. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J. Bone Miner. Res. 1996, 11:530-534.
6. Garnero P., Arden N.K., Griffiths G., Delmas P.D., Spector T.D. Genetic influence on bone turnover in postmenopausal twins. J. Clin. Endocrinol. Metab. 1996, 81:140-146.
7. Peacock M., Turner C.H., Econs M.J., Foroud T. Genetics of osteoporosis. Endocr. Rev. 2002, 23:378-383.
8. Ralston S.H. Genetic determinants of osteoporosis. Curr. Opin. Rheumatol. 2005, 17:475-479.
9. Klein R.F. Genetics of osteoporosis-utility of mouse models. J. Musculoskelet. Neuronal Interact. 2008, 8:287-290.
10. Liu Y.J., Shen H., Xiao P., Xiong D.H., Li L.H., Recker R.R., et al. Molecular genetic studies of gene identification for osteoporosis: a 2004 update. J. Bone Miner. Res. 2006, 21:1511-1535.
11. Zmuda J.M., Sheu Y.T., Moffett S.P. The search for human osteoporosis genes. J. Musculoskelet. Neuronal Interact. 2006, 6:3-15.
12. Lelovas P.P., Xanthos T.T., Thoma S.E., Lyritis G.P., Dontas I.A. The laboratory rat as an animal model for osteoporosis research. Comp. Med. 2008, 58:424-430.
13. Xiong Q., Han C., Beamer W.G., Gu W. A close examination of genes within quantitative trait loci of bone mineral density in whole mouse genome. Crit. Rev. Eukaryot. Gene Expr. 2008, 18:323-343.
14. Rosen C.J., Beamer W.G., Donahue L.R. Defining the genetics of osteoporosis: using the mouse to understand man. Osteoporos. Int. 2001, 12:803-810.
15. Wronski T.J., Walsh C.C., Ignaszewski L.A. Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats. Bone 1986, 7:119-123.
16. Bonjour J.P., Ammann P., Rizzoli R. Importance of preclinical studies in the development of drugs for treatment of osteoporosis: a review related to the 1998 WHO guidelines. Osteoporos. Int. 1999, 9:379-393.
17. Turner C.H., Roeder R.K., Wieczorek A., Foroud T., Liu G., Peacock M. Variability in skeletal mass, structure, and biomechanical properties among inbred strains of rats. J. Bone Miner. Res. 2001, 16:1532-1539.
18. Alam I., Sun Q., Liu L., Koller D.L., Carr L.G., Econs M.J., et al. Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats. J. Bone Miner. Res. 2008, 23:850-859.
19. Sun Q., Alam I., Liu L., Koller D.L., Carr L.G., Econs M.J., et al. Genetic loci affecting bone structure and strength in inbred COP and DA rats. Bone 2008, 42:547-553.
20. Alam I., Sun Q., Liu L., Koller D.L., Fishburn T., Carr L.G., et al. Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength. Bone 2006, 39:93-99.
21. Alam I., Sun Q., Liu L., Koller D.L., Fishburn T., Carr L.G., et al. Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats. J. Bone Miner. Res. 2005, 20:1589-1596.
22. Koller D.L., Alam I., Sun Q., Liu L., Fishburn T., Carr L.G., et al. Genome screen for bone mineral density phenotypes in Fischer 344 and Lewis rats. Mamm. Genome 2005, 16:578-586.
23. Alam I., Sun Q., Koller D.L., Liu L., Liu Y., Edenberg H.J., et al. Genes influencing spinal bone mineral density in inbred F344, LEW, COP and DA rats. Funct. Integr. Genomics 2009, 10:63-72.
24. Alam I., Sun Q., Koller D.L., Liu L., Liu Y., Edenberg H.J., et al. Differentially expressed genes strongly correlated with femur strength in rats. Genomics 2009, 94:257-262.
25. Alam I., Sun Q., Liu L., Koller D.L., Liu Y., Edenberg H.J., et al. Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck. Physiol. Genomics 2008, 35:191-196.
26. Hansen C., Spuhler K. Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol. Clin. Exp. Res. 1984, 8:477-479.
27. Boucher W., Cotterman C.W. On the classification of regular systems of inbreeding. J. Math. Biol. 1990, 28:293-305.
28. Mott R., Talbot C.J., Turri M.G., Collins A.C., Flint J. A method for fine mapping quantitative trait loci in outbred animal stocks. Proc. Natl Acad. Sci. USA 2000, 97:12649-12654.
29. Solbergwoods L.C., Holl K., Tschannen M., Valdar W. Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiol. Genomics 2010, 41:102-108.
30. Johannesson M., Lopez-Aumatell R., Stridh P., Diez M., Tuncel J., Blázquez G., et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res. 2009, 19:150-158.
31. Falconer D.S., Mackay T.F.C. Introduction to Quantita tive Genetics, Ed 4 1996, Longmans Green, Harlow, Essex, UK.
32. Peacock M., Koller D.L., Lai D., Hui S., Foroud T., Econs M.J. Bone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci. Bone 2009, 45:443-448.
33. Peacock M., Buckwalter K.A., Persohn S., Hangartner T.N., Econs M.J., Hui S. Race and sex differences in bone mineral density and geometry at the femur. Bone 2009, 45:218-225.