SmQnrR, a DeoR-type transcriptional regulator, negatively regulates the expression of Smqnr and SmtcrA in Stenotrophomonas maltophilia

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 5, 2011, Pages 1024-1028

  Chang, Yi Chih ^a,b   Tsai, Mei Jung ^b   Huang, Yi Wei ^a   Chung, Tung Ching ^a   Yang, Tsuey Ching ^b  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

DeoR family transcriptional regulator; Major facilitator superfamily; Quinolone resistance; Smqnr; Tetracycline resistance

Indexed keywords

BACTERIAL PROTEIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SMQNR PROTEIN; SMQNRR PROTEIN; SMTCRA PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM MUTANT; GENE EXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; STENOTROPHOMONAS MALTOPHILIA; TRANSCRIPTION REGULATION; WILD TYPE;

ANTI-BACTERIAL AGENTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; QUINOLONES; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; STENOTROPHOMONAS MALTOPHILIA; TETRACYCLINE;

EID: 79954575097     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr049     Document Type: Article

References (11)

1. Robicsek A, Strahilevitz J, Jacoby GA et al. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med 2006; 12: 83-8.
2. Cattoir V, Nordmann P. Plasmid-mediated quinolone resistance in Gram-negative bacterial species: an update. Curr Med Chem 2009; 16: 1028-46.
3. Shimizu K, Kikuchi K, Sasaki T et al. Smqnr, a new chromosomal-carried quinolone resistance gene in Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2008; 52: 3823-5.
4. Sanchez MB, Martinez JL. SmQnr contributes to intrinsic resistance to quinolones in Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2010; 54: 580-1.
5. Gordon NC, Wareham DW. Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophilia. J Antimicrob Chemother 2010; 65: 483-9.
6. Crossman LC, Gould VC, Dow JM et al. The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biol 2008; 9: R74.
7. Hu RM, Huang KJ, Wu LT et al. Induction of L1 and L2 b-lactamases of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2008; 52: 1198-200.
8. Yang TC, Huang YW, Hu RM et al. AmpDI is involved in expression of the chromosomal L1 and L2 b-lactamases of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 2009; 53: 2902-7.
9. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing of Bacteria: Nineteenth Informational Supplement M100-S19. CLSI, Wayne, PA, USA, 2009.
10. Lewinson O, Adler J, Sigal N et al. Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters. Mol Microbiol 2006; 61: 277-84.
11. Sanchez MB, Hernandez A, Rodriguez-Martinez JM et al. Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol 2008; 8: 148.