Predictors of nosocomial bloodstream infections in older adults

Journal of the American Geriatrics Society

Volumn 59, Issue 4, 2011, Pages 622-627

  Kaye, Keith S ^a   Marchaim, Dror ^a,e   Chen, Ting Yi ^a   Chopra, Teena ^b   Anderson, Deverick J ^b   Choi, Yong ^c   Sloane, Richard ^a   Schmader, Kenneth E ^b,d  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DURHAM VA MEDICAL CENTER   (United States)

^e HARPER UNIVERSITY HOSPITAL   (United States)

Author keywords

bacteremia; BSI; elderly; MRSA; nosocomial; predictors; risk factors

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ADL DISABILITY; AGED; ARTICLE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; BLOODSTREAM INFECTION; CASE CONTROL STUDY; CATHETER INFECTION; CENTRAL VENOUS CATHETER; CEREBROVASCULAR ACCIDENT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ASSESSMENT; COAGULASE NEGATIVE STAPHYLOCOCCUS; COMORBIDITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DEMENTIA; DIABETES MELLITUS; DIABETES MELLITUS WITH END ORGAN DAMAGE; DIALYSIS; FEEDING; GASTROSTOMY; GERIATRIC PATIENT; HEART INFARCTION; HEMIPLEGIA; HOSPITAL INFECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION CONTROL; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIVARIATE ANALYSIS; OBESITY; PATIENT SAFETY; PEPTIC ULCER; PROGNOSIS; RETROSPECTIVE STUDY; RISK REDUCTION; URINE INCONTINENCE;

AGED; BACTEREMIA; CATHETERIZATION; CROSS INFECTION; FEMALE; HUMANS; INCIDENCE; LENGTH OF STAY; MALE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; UNITED STATES;

EID: 79954572545     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2010.03289.x     Document Type: Article

References (42)

1. Klevens RM, Edwards JR, Richards CL Jr., et al,. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007; 122: 160-166.
2. Al-Rawajfah OM, Stetzer F, Beauchamp Hewitt J., Incidence of and risk factors for nosocomial bloodstream infections in adults in the United States, 2003. Infect Control Hosp Epidemiol 2009; 30: 1036-1044.
3. Kim PW, Perl TM, Keelaghan EF, et al,. Risk of mortality with a bloodstream infection is higher in the less severely ill at admission. Am J Respir Crit Care Med 2005; 171: 616-620. (Pubitemid 40365417)
4. Wisplinghoff H, Bischoff T, Tallent SM, et al,. Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39: 309-317.
5. Kilgore M, Brossette S., Cost of bloodstream infections. Am J Infect Control 2008; 36 S172 e171-e173.
6. Laupland K, Gregson DB, Kirkpatrick AW, et al,. Bloodstream infection complicating trauma. Clin Invest Med 2004; 27: 253-258. (Pubitemid 39664809)
7. Laupland KB, Gregson DB, Zygun DA, et al,. Severe bloodstream infections: A population-based assessment. Crit Care Med 2004; 32: 992-997.
8. Laupland KB, Lee H, Gregson DB, et al,. Cost of intensive care unit-acquired bloodstream infections. J Hosp Infect 2006; 63: 124-132.
9. Munoz-Price LS, Hota B, Stemer A, et al,. Prevention of bloodstream infections by use of daily chlorhexidine baths for patients at a long-term acute care hospital. Infect Control Hosp Epidemiol 2009; 30: 1031-1035.
10. Pittet D, Tarara D, Wenzel RP., Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1994; 271: 1598-1601.
11. Scott RD., The direct medical costs of healthcare-associated infections in U.S. hospitals and the benefits of prevention, 2009 [on-line]. Available at Accessed October 10, 2010.
12. Suljagic V, Cobeljic M, Jankovic S, et al,. Nosocomial bloodstream infections in ICU and non-ICU patients. Am J Infect Control 2005; 33: 333-340. (Pubitemid 41078771)
13. Warren DK, Zack JE, Elward AM, et al,. Nosocomial primary bloodstream infections in intensive care unit patients in a nonteaching community medical center: A 21-month prospective study. Clin Infect Dis 2001; 33: 1329-1335. (Pubitemid 32955182)
14. Apostolopolou E, Katsaris G, Katostaras T., Risk factors for nosocomial bloodstream infections. Br J Nurs 2003; 12 (12):718, 720-716.
15. World's Population Getting Older, 2009 [on-line]. Available at Accessed October 10, 2010.
16. Girard TD, Ely EW., Bacteremia and sepsis in older adults. Clin Geriatr Med 2007; 23: 633-647, viii. (Pubitemid 47053882)
17. Leibovici L, Pitlik SD, Konisberger H, et al,. Bloodstream infections in patients older than eighty years. Age Ageing 1993; 22: 431-442. (Pubitemid 23348151)
18. Malani PN, Rana MM, Banerjee M, et al,. Staphylococcus aureus bloodstream infections: The association between age and mortality and functional status. J Am Geriatr Soc 2008; 56: 1485-1489.
19. Dellinger RP, Levy MM, Carlet JM, et al,. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36: 296-327.
20. Garner JS, Jarvis WR, Emori TG, et al,. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16: 128-140.
21. The Clinical and Laboratory Standards Institute. Performance standards for antimibrobial susceptibility testing. Sixteenth informational supplement. Approved standard M100-S16 Wayne, PA: CLSI; 2006. Report No.: Approved standard M100-S16.
22. Harris AD, Samore MH, Lipsitch M, et al,. Control-group selection importance in studies of antimicrobial resistance: Examples applied to Pseudomonas aeruginosa, Enterococci, and Escherichia coli. Clin Infect Dis 2002; 34: 1558-1563.
23. Charlson ME, Pompei P, Ales KL, et al,. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40: 373-383. (Pubitemid 17055592)
24. Bion JF, Edlin SA, Ramsay G, et al,. Validation of a prognostic score in critically ill patients undergoing transport. BMJ (Clin Res Ed) 1985; 291: 432-434. (Pubitemid 15012888)
25. McCabe R, Reid WM, Knox WG., Evaluation of the use of a temporary percutaneous endotracheal catheter in the treatment and prevention of postoperative pulmonary complications. Ann Surg 1962; 156: 5-8.
26. Katz S, Ford AB, Moskowitz RW, et al,. Studies of illness in the aged. The Index of ADL: A standardized measure of biological and psychosocial function. JAMA 1963; 185: 914-919.
27. O'Grady NP, Alexander M, Dellinger EP, et al,. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm Rep 2002; 51 (RR-10): 1-29.
28. Anderson DJ, Chen LF, Schmader KE, et al,. Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol 2008; 29: 832-839.
29. Chen TY, Anderson DJ, Chopra T, et al,. Poor functional status is an independent predictor of surgical site infections due to methicillin-resistant Staphylococcus aureus in older adults. J Am Geriatr Soc 2010; 58: 527-532.
30. Tsai CC, Bradley SF., Group A streptococcal bacteremia associated with gastrostomy feeding tube infections in a long-term care facility. J Am Geriatr Soc 1992; 40: 821-823.
31. De Groote MA, Frank DN, Dowell E, et al,. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005; 24: 278-280. (Pubitemid 40365870)
32. Dormann AJ, Wigginghaus B, Risius H, et al,. A single dose of ceftriaxone administered 30 minutes before percutaneous endoscopic gastrostomy significantly reduces local and systemic infective complications. Am J Gastroenterol 1999; 94: 3220-3224.
33. Rey JR, Axon A, Budzynska A, et al,. Guidelines of the European Society of Gastrointestinal Endoscopy (E.S.G.E.) antibiotic prophylaxis for gastrointestinal endoscopy. European Society of Gastrointestinal Endoscopy. Endoscopy 1998; 30: 318-324. (Pubitemid 28223118)
34. Sreeramoju PV, Tolentino J, Garcia-Houchins S, et al,. Predictive factors for the development of central line-associated bloodstream infection due to gram-negative bacteria in intensive care unit patients after surgery. Infect Control Hosp Epidemiol 2008; 29: 51-56. (Pubitemid 351267774)
35. Costello JM, Graham DA, Morrow DF, et al,. Risk factors for central line-associated bloodstream infection in a pediatric cardiac intensive care unit. Pediatr Crit Care Med 2009; 10: 453-459.
36. Linares L, Garcia-Goez JF, Cervera C, et al,. Early bacteremia after solid organ transplantation. Transplant Proc 2009; 41: 2262-2264.
37. Yoshida J, Ishimaru T, Fujimoto M, et al,. Risk factors for central venous catheter-related bloodstream infection: A 1,073-patient study. J Infect Chemother 2008; 14: 399-403.
38. Turnidge JD, Kotsanas D, Munckhof W, et al,. Staphylococcus aureus bacteraemia: A major cause of mortality in Australia and New Zealand. Med J Aust 2009; 191: 368-373.
39. Cosgrove SE, Qi Y, Kaye KS, et al,. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: Mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005; 26: 166-174.
40. Cosgrove SE, Sakoulas G, Perencevich EN, et al,. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: A meta-analysis. Clin Infect Dis 2003; 36: 53-59. (Pubitemid 36099097)
41. Leibovici L, Shraga I, Drucker M, et al,. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998; 244: 379-386. (Pubitemid 28513125)
42. Bleasdale SC, Trick WE, Gonzalez IM, et al,. Effectiveness of chlorhexidine bathing to reduce catheter-associated bloodstream infections in medical intensive care unit patients. Arch Intern Med 2007; 167: 2073-2079. (Pubitemid 350036706)