Diabetes mellitus as a risk factor for cancer: Is predictive diagnosis possible?

Predictive Diagnostics and Personalized Treatment: Dream or Reality

Volumn , Issue , 2009, Pages 247-262

  Cebioglu, Melanie ^a   Schild, Hans H ^a   Golubnitschaja, Olga ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79954559533     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (85)

1. van de Poll-Franse LV, Houterman S, Janssen-Heijnen ML, Dercksen MW, Coebergh JW, Haak HR (2007) Less aggressive treatment and worse overall survival in cancer patients with diabetes: a large population based analysis. Int. J. Cancer, 120, 1986-1992.
2. Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ (2004) Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am. J. Epidemiol., 159, 1160-1167.
3. Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA, 293, 194-202.
4. Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S (2006) Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch. Intern. Med., 166, 1871-1877.
5. Larsson SC, Mantzoros CS, Wolk A (2007) Diabetes mellitus and risk of breast cancer: a meta-analysis. Int. J. Cancer, 121, 856-862.
6. Friberg E, Orsini N, Mantzoros CS, Wolk A (2007) Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia, 50, 1365-1374.
7. Larsson SC, Orsini N, Wolk A (2005) Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J. Natl. Cancer Inst., 97, 1679-1687.
8. Wang F, Gupta S, Holly EA (2006) Diabetes mellitus and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. Cancer Epidemiol. Biomarkers Prev., 15, 1458-1463.
9. Adami HO, McLaughlin J, Ekbom A, Berne C, Silverman D, Hacker D, Persson I (1991) Cancer risk in patients with diabetes mellitus. Cancer Causes Control, 2, 307-314.
10. Zendehdel K, Nyrén O, Ostenson CG, Adami HO, Ekbom A, Ye W (2003) Cancer incidence in patients with type 1 diabetes mellitus: a population-based cohort study in Sweden. J. Natl. Cancer Inst., 95, 1797-1800.
11. Verlato G, Zoppini G, Bonora E, Muggeo M (2003) Mortality from site-specific malignancies in type 2 diabetic patients from Verona. Diabetes Care, 26, 1047-1051.
12. Xue F, Michels KB (2007) Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. Am. J. Clin. Nutr., 86, 823-835.
13. Swerdlow AJ, Laing SP, Qiao Z, Slater SD, Burden AC, Botha JL, Waugh NR, Morris AD, Gatling W, Gale EA, Patterson CC, Keen H (2005) Cancer incidence and mortality in patients with insulin-treated diabetes: a UK cohort study. Br. J. Cancer, 92, 2070-2075.
14. Rose DP, Haffner SM, Baillargeon J (2007) Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women. Endocr. Rev., 28, 763-777.
15. Mori M, Saitoh S, Takagi S, Obara F, Ohnishi H, Akasaka H, Izumi H, Sakauchi F, Sonoda T, Nagata Y, Shimamoto K (2000) A Review of Cohort Studies on the Association Between History of Diabetes Mellitus and Occurrence of Cancer. Asian Pac. J. Cancer Prev., 1, 269-276.
16. Chung YW, Han DS, Park KH, Eun CS, Yoo KS, Park CK (2008) Insulin therapy and colorectal adenoma risk among patients with Type 2 diabetes mellitus: a case-control study in Korea. Dis. Colon Rectum, 51, 593-597.
17. Larsson SC, Orsini N, Brismar K, Wolk A (2006) Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia, 49, 2819-2823.
18. Suba Z, Ujpál M (2007) Disorders of glucose metabolism and risk of oral cancer. Fogorv. Sz., 100, 250-257.
19. Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, Borch-Johnsen K, Olsen JH (1997) Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J. Natl. Cancer Inst., 89, 1360-1365.
20. Vairaktaris E, Kalokerinos G, Goutzanis L, Spyridonidou S, Vassiliou S, Derka S, Nkenke E, Yapijakis C, Vylliotis A, Lazaris A, Patsouris E (2007) Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis. Anticancer Res., 27, 1465-1473.
21. Drechsler K, Fikenzer S, Sechtem U, Blank E, Breithardt G, Zeymer U, Niebauer J (2008) The Euro Heart Survey - Germany: diabetes mellitus remains unrecognized in patients with coronary artery disease. Clin. Res. Cardiol., 97, 364-370.
22. Hofmann MA, Schiekofer S, Isermann B, Kanitz M, Henkels M, Joswig M, Treusch A, Morcos M, Weiss T, Borcea V, Abdel Khalek AK, Amiral J, Tritschler H, Ritz E, Wahl P, Ziegler R, Bierhaus A, Nawroth PP (1999) Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. Diabetologia, 42, 222-232.
23. Bierhaus A, Schiekofer S, Schwaninger M, Andrassy M, Humpert PM, Chen J, Hong M, Luther T, Henle T, Klöting I, Morcos M, Hofmann M, Tritschler H, Weigle B, Kasper M, Smith M, Perry G, Schmidt AM, Stern DM, Häring HU, Schleicher E, Nawroth PP (2001) Diabetes- associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes, 50, 2792-2808.
24. Kowluru RA, Chan PS (2007) Oxidative stress and diabetic retinopathy. Exp. Diabetes Res., 2007, 43603.
25. Palmeira CM, Rolo AP, Berthiaume J, Bjork JA, Wallace KB (2007) Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis. Toxicol. Appl. Pharmacol., 225, 214-220.
26. Khan ZA, Farhangkhoee H, Chakrabarti S (2006) Towards newer molecular targets for chronic diabetic complications. Curr. Vasc. Pharmacol., 4, 45-57.
27. Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED (2007) Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes, 56, 2457-2466.
28. Ricci C, Pastukh V, Mozaffari M, Schaffer SW (2007) Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Can. J. Physiol. Pharmacol., 85, 455-464.
29. Dröge W (2002) Free radicals in the physiological control of cell function. Physiol. Rev., 82, 47-95.
30. Baynes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes, 40, 405-412.
31. Hou N, Torii S, Saito N, Hosaka M, Takeuchi T (2008) Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases. Endocrinology, 149, 1654-1665.
32. Rolo AP, Palmeira CM (2006) Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol. Appl. Pharmacol., 212, 167-178.
33. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B, Anversa P (2000) Myocardial cell death in human diabetes. Circ. Res., 87, 1123-1132.
34. Golubnitschaja O (2007) Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases. Amino Acids, 32, 359-371.
35. Ohta S (2003) A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease. Curr. Med. Chem., 10, 2485-2494.
36. Golubnitschaja O (2008) Clinical Proteomics in Application to Predictive Diagnostics and Personalized Treatment of Diabetic Patients. Current Proteomics, 5, 35-44.
37. Xu L, Hu Y, Chen B, Tang W, Han X, Yu H, Xiao C (2006) Mitochondrial polymorphisms as risk factors for endometrial cancer in southwest China. Int. J. Gynecol. Cancer, 16, 1661-1667.
38. Alexeyev MF, Ledoux SP, Wilson GL (2004) Mitochondrial DNA and aging. Clin. Sci., 107, 355-364.
39. Bai RK, Leal SM, Covarrubias D, Liu A, Wong LJ (2007) Mitochondrial genetic background modifies breast cancer risk. Cancer Res., 67, 4687-4694.
40. Van Houten B, Woshner V, Santos JH (2006) Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst.), 5, 145-152.
41. Bener A, Micallef R, Afifi M, Derbala M, Al-Mulla HM, Usmani MA (2007) Association between type 2 diabetes mellitus and Helicobacter pylori infection. Turk. J. Gastroenterol., 18, 225-229.
42. Movahed MR, Hashemzadeh M, Jamal MM (2007) Increased prevalence of infectious endocarditis in patients with type II diabetes mellitus. J. Diabetes Complicat., 21, 403-406.
43. Ojetti V, Migneco A, Silveri NG, Ghirlanda G, Gasbarrini G, Gasbarrini A (2005) The Role of H. pylori Infection in Diabetes. Curr. Diabetes Rev., 1, 343-347.
44. Foss NT, Foss-Freitas MC, Ferreira MA, Cardili RN, Barbosa CM, Foss MC (2007) Impaired cytokine production by peripheral blood mononuclear cells in type 1 diabetic patients. Diabetes Metab., 33, 439-443.
45. Hopps E, Camera A, Caimi G (2008) Polimorphonuclear leukocytes and diabetes mellitus. Minerva Med., 99, 197-202.
46. Barnea M, Madar Z, Froy O (2008) Glucose and insulin are needed for optimal defensin expression in human cell lines. Biochem. Biophys. Res. Commun., 367, 452-456.
47. Ali SS, Ali IS, Aamir AH, Jadoon Z, Inayatullah S (2007) Frequency of hepatitis C infection in diabetic patients. J. Ayub. Med. Coll. Abbottabad, 19, 46-49.
48. Sangiorgio L, Attardo T, Gangemi R, Rubino C, Barone M, Lunetta M (2000) Increased frequency of HCV and HBV infection in type 2 diabetic patients. Diabetes Res. Clin. Pract., 48, 147-151.
49. Banerjee S, Banerjee M (2006) Hepatitis C and diabetes mellitus. J. Indian Med. Assoc., 104, 86-89.
50. Shera KA, Shera CA, McDougall JK (2001) Small tumor virus genomes are integrated near nuclear matrix attachment regions in transformed cells. J. Virol., 75, 12339-12346.
51. Popescu NC, Zimonjic DB (2002) Chromosome-mediated alterations of the MYC gene in human cancer. J. Cell Mol. Med., 6, 151-159.
52. de Villiers EM, Sandstrom RE, zur Hausen H, Buck CE (2005) Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast. Breast Cancer Res., 7, 1-11.
53. Lawson JS, Günzburg WH, Whitaker NJ (2006) Viruses and human breast cancer. Future Microbiol., 1, 33-51.
54. Hemann MT, Narita M (2007) Oncogenes and senescence: breaking down in the fast lane. Genes Dev., 21, 1-5.
55. Ben-Yosef T, Yanuka O, Halle D, Benvenisty N (1998) Involvement of Myc targets in c-myc and N-myc induced human tumors. Oncogene, 17, 165-171.
56. Pontén J, Guo Z (1998) Precancer of the human cervix. Cancer Surv., 32, 201-229.
57. Johnson CN, Levy LS (2005) Matrix attachment regions as targets for retroviral integration. Virol. J., 2, 68.
58. Hebner CM, Laimins LA (2006) Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity. Rev. Med. Virol., 16, 83-97.
59. Berger FG (2004) The interleukin-6 gene: a susceptibility factor that may contribute to racial and ethnic disparities in breast cancer mortality. Breast Cancer Res. Treat., 88, 281-285.
60. Di Pietro PF, Medeiros NI, Vieira FG, Fausto MA, Belló-Klein A (2007) Breast cancer in southern Brazil: association with past dietary intake. Nutr. Hosp., 22, 565-572.
61. Fejerman L, Ziv E (2008) Population differences in breast cancer severity. Pharmacogenomics, 9, 323-333.
62. Celis JE, Moreira JM, Cabezón T, Gromov P, Friis E, Rank F, Gromova I (2005) Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromal cell interactions. Mol. Cell Proteomics, 4, 492-522.
63. Xue Y, Guo XT, Liu WC (2007) Clinical research advancement on male breast cancer. Ai Zheng, 26, 1148-1152.
64. Benchellal Z, Wagner A, Harchaoui Y, Huten N, Body G (2002) Male breast cancer: 19 case reports. Ann. Chir., 127, 619-623.
65. Riedl M, Kotzmann H, Luger A (2001) Growth hormone in the elderly man. Wien. Med. Wochenschr., 151, 426-429.
66. Abu-Abid S, Szold A, Klausner J (2002) Obesity and cancer. J. Med., 33, 73-86.
67. Kruk J (2007) Physical activity in the prevention of the most frequent chronic diseases: an analysis of the recent evidence. Asian Pac. J. Cancer Prev., 8, 325-338.
68. Irigaray P, Newby JA, Clapp R, Hardell L, Howard V, Montagnier L, Epstein S, Belpomme D (2007) Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed. Pharmacother., 61, 640-658.
69. Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M (2005) Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet, 366, 1784-1793.
70. Lowenfels AB, Maisonneuve P (2005) Risk factors for pancreatic cancer. J. Cell Biochem., 95, 649-656.
71. Hart AR, Kennedy H, Harvey I (2008) Pancreatic cancer: a review of the evidence on causation. Clin. Gastroenterol. Hepatol., 6, 275-282.
72. Hermansen K, Jørgensen K, Schmidt EB, Tjønneland A, Tolstrup JS, Grønbaek MN (2007) Alcohol and lifestyle diseases. Ugeskr. Laeg, 169, 3404-3406.
73. Page NM, Kemp CF, Butlin DJ, Lowry PJ (2002) Placental peptides as markers of gestational disease. Reproduction, 123, 487-495.
74. Schweigert FJ (2007) Nutritional proteomics: methods and concepts for research in nutritional science. Ann. Nutr. Metab., 51, 99-107.
75. Mathers JC, Hesketh JE (2007) The biological revolution: understanding the impact of SNPs on diet-cancer interrelationships. J. Nutr., 137, 253-258.
76. Howard RA, Freedman DM, Park Y, Hollenbeck A, Schatzkin A, Leitzmann MF (2008) Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control, 19, 939-953.
77. Gago-Dominguez M, Jiang X, Castelao JE (2007) Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. Breast Cancer Res., 9, 201.
78. Loizidou MA, Michael T, Neuhausen SL, Newbold RF, Marcou Y, Kakouri E, Daniel M, Papadopoulos P, Malas S, Kyriacou K, Hadjisavvas A (2008) Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. Breast Cancer Res. Treat., 112, 575-579.
79. Mahabir S, Wei Q, Barrera SL, Dong YQ, Etzel C, Spitz MR, Forman MR (2008) Dietary magnesium and DNA repair capacity as risk factors for lung cancer. Carcino-genesis, 29, 949-956.
80. Yu D, Zhang X, Liu J, Yuan P, Tan W, Guo Y, Sun T, Zhao D, Yang M, Liu J, Xu B, Lin D (2008) Characterization of functional excision repair cross-complementation group 1 variants and their association with lung cancer risk and prognosis. Clin. Cancer Res., 14, 2878-2886.
81. Munday R, Zhang Y, Fahey JW, Jobson HE, Munday CM, Li J, Stephenson KK (2006) Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay. Nutr. Cancer, 54, 223-231.
82. Saikali J, Picard C, Freitas M, Holt P (2004) Fermented milks, probiotic cultures, and colon cancer. Nutr. Cancer, 49, 14-24.
83. Bonassi S, Znaor A, Norppa H, Hagmar L (2004) Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective. Cytogenet. Genome Res., 104, 376-382.
84. Jee SH, Ohrr H, Sull JW, Yun JE, Ji M, Samet JM (2005) Fasting serum glucose level and cancer risk in Korean men and women. JAMA, 293, 194-202.
85. Mönkemann H, De Vriese AS, Blom HJ, Kluijtmans LA, Heil SG, Schild HH, Golubnitschaja O (2002) Early molecular events in the development of the diabetic cardiomyopathy. Amino Acids, 23, 331-336.