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Volumn 112, Issue 6, 2011, Pages 1506-1513

The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation

Author keywords

digeranyl bisphophonate; geranylgeranyl; isoprenoid; statins

Indexed keywords

ALKALINE PHOSPHATASE; DIGERANYL BISPHOSPHONATE; ENZYME INHIBITOR; FARNESYL TRANS TRANSFERASE; GLUCOCORTICOID RECEPTOR; OSTEOCALCIN; UNCLASSIFIED DRUG;

EID: 79954557143     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23087     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 77953527601 scopus 로고    scopus 로고
    • Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3
    • Bang S, Yoo S, Yang TJ, Cho H, Hwang SW,. 2010. Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. J Biol Chem 285: 19352-19371.
    • (2010) J Biol Chem , vol.285 , pp. 19352-19371
    • Bang, S.1    Yoo, S.2    Yang, T.J.3    Cho, H.4    Hwang, S.W.5
  • 2
    • 77951624097 scopus 로고    scopus 로고
    • Update in new anabolic therapies for osteoporosis
    • Canalis E,. 2010. Update in new anabolic therapies for osteoporosis. J Clin Endo Metab 95: 1496-1504.
    • (2010) J Clin Endo Metab , vol.95 , pp. 1496-1504
    • Canalis, E.1
  • 3
    • 34548554688 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteoporosis: Pathophysiology and therapy
    • DOI 10.1007/s00198-007-0394-0
    • Canalis E, Mazziotti G, Giustina A, Bilezikian JP,. 2007. Glucocorticoid-induced osteoporosis: Pathophysiology and therapy. Osteoporos Int 18: 1319-1328. (Pubitemid 47389469)
    • (2007) Osteoporosis International , vol.18 , Issue.10 , pp. 1319-1328
    • Canalis, E.1    Mazziotti, G.2    Giustina, A.3    Bilezikian, J.P.4
  • 4
    • 77950532155 scopus 로고    scopus 로고
    • Effects of statins vs. non-statin lipid-lowering therapy on bone formation and bone mineral density biomarkers in patients with hyperlipidemia
    • Chuengsamarn S, Rattanamongkoulgul S, Suwanwalaikorn S, Wattanasirichaigoon S, Kaufman L,. 2010. Effects of statins vs. non-statin lipid-lowering therapy on bone formation and bone mineral density biomarkers in patients with hyperlipidemia. Bone 46: 1011-1015.
    • (2010) Bone , vol.46 , pp. 1011-1015
    • Chuengsamarn, S.1    Rattanamongkoulgul, S.2    Suwanwalaikorn, S.3    Wattanasirichaigoon, S.4    Kaufman, L.5
  • 5
    • 33747041999 scopus 로고    scopus 로고
    • Developments in the pharmacotherapeutic management of osteoporosis
    • DOI 10.1517/14656566.7.12.1603
    • Close P, Neuprez A, Reginster JY,. 2006. Developments in the pharmacotherapeutic management of osteoporosis. Expert Opin Pharmacother 7: 1603-1615. (Pubitemid 44209604)
    • (2006) Expert Opinion on Pharmacotherapy , vol.7 , Issue.12 , pp. 1603-1615
    • Close, P.1    Neuprez, A.2    Reginster, J.-Y.3
  • 6
    • 77954165040 scopus 로고    scopus 로고
    • Osteoporosis: Social and economic impact
    • Compston J,. 2010. Osteoporosis: Social and economic impact. Radiol Clin N Am 48: 477-482.
    • (2010) Radiol Clin N Am , vol.48 , pp. 477-482
    • Compston, J.1
  • 7
    • 35649022675 scopus 로고    scopus 로고
    • Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors
    • DOI 10.1210/me.2007-0080
    • Das S, Schapira M, Tomic-Canic M, Goyanka R, Cardoza T, Samuels HH,. 2007. Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors. Mol Endocrinol 21: 2672-2686. (Pubitemid 350035150)
    • (2007) Molecular Endocrinology , vol.21 , Issue.11 , pp. 2672-2686
    • Das, S.1    Schapira, M.2    Tomic-Canic, M.3    Goyanka, R.4    Cardozo, T.5    Samuels, H.H.6
  • 8
    • 38449112480 scopus 로고    scopus 로고
    • Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells
    • DOI 10.1359/jbmr.070701
    • Duque G, Rivas D,. 2007. Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells. J Bone Miner Res 22: 1603-1611. (Pubitemid 351229330)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.10 , pp. 1603-1611
    • Duque, G.1    Rivas, D.2
  • 9
    • 63449128847 scopus 로고    scopus 로고
    • Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation
    • Ebert R, Zeck S, Krug R, Meissner-Weigl J, Schneider D, Seefried L, Eulert J, Jakob F,. 2009. Pulse treatment with zoledronic acid causes sustained commitment of bone marrow derived mesenchymal stem cells for osteogenic differentiation. Bone 44: 858-864.
    • (2009) Bone , vol.44 , pp. 858-864
    • Ebert, R.1    Zeck, S.2    Krug, R.3    Meissner-Weigl, J.4    Schneider, D.5    Seefried, L.6    Eulert, J.7    Jakob, F.8
  • 10
    • 0017754661 scopus 로고
    • Inhibition of cholesterol synthesis in vitro and in vivo by ML 236A and ML 236B, competitive inhibitors of 3 hydroxy 3 methylglutaryl Coenzyme A reductase
    • Endo A, Tsujita Y, Kuroda M, Tanzawa K,. 1977. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Eur J Biochem 77: 31-36. (Pubitemid 8122952)
    • (1977) European Journal of Biochemistry , vol.77 , Issue.1 , pp. 31-36
    • Endo, A.1    Tsujita, Y.2    Kuroda, M.3    Tanzawa, K.4
  • 12
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein J, Brown MS,. 1990. Regulation of the mevalonate pathway. Nature 343: 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.1    Brown, M.S.2
  • 13
    • 2342559147 scopus 로고    scopus 로고
    • An Alizarin red-based assay of mineralization by adherent cells in culture: Comparison with cetylpyridinium chloride extraction
    • DOI 10.1016/j.ab.2004.02.002, PII S0003269704001332
    • Gregory C, Gunn WG, Peister A, Prockop DJ,. 2004. An Alizarin red-based assay of mineralization by adherent cells in culture: Comparison with cetylpyridinium chloride extraction. Anal Biochem 329: 77-84. (Pubitemid 38596903)
    • (2004) Analytical Biochemistry , vol.329 , Issue.1 , pp. 77-84
    • Gregory, C.A.1    Gunn, W.G.2    Peister, A.3    Prockop, D.J.4
  • 14
    • 33745039765 scopus 로고    scopus 로고
    • Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations
    • DOI 10.1007/s00198-006-0079-0
    • Gutierrez G, Lalka D, Garrett IR, Rossini G, Mundy GR,. 2006. Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporosis Int 17: 1033-1042. (Pubitemid 43869919)
    • (2006) Osteoporosis International , vol.17 , Issue.7 , pp. 1033-1042
    • Gutierrez, G.E.1    Lalka, D.2    Garrett, I.R.3    Rossini, G.4    Mundy, G.R.5
  • 15
    • 58149492521 scopus 로고    scopus 로고
    • BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: Potential therapeutic targets for glucocorticoid-induced osteoporosis
    • Hayashi K, Yamaguchi T, Yano S, Kanazawa I, Yamauchi M, Yamamoto M, Sugimoto T,. 2009. BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: Potential therapeutic targets for glucocorticoid-induced osteoporosis. Biochem Biophys Res Comm 379: 261-266.
    • (2009) Biochem Biophys Res Comm , vol.379 , pp. 261-266
    • Hayashi, K.1    Yamaguchi, T.2    Yano, S.3    Kanazawa, I.4    Yamauchi, M.5    Yamamoto, M.6    Sugimoto, T.7
  • 16
    • 3242785011 scopus 로고    scopus 로고
    • Isoprenoids: Remarkable diversity of form and function
    • DOI 10.1007/s11745-004-1233-3
    • Holstein S, Hohl RJ,. 2004. Isoprenoids: Remarkable diversity of form and function. Lipids 39: 293-309. (Pubitemid 38971743)
    • (2004) Lipids , vol.39 , Issue.4 , pp. 293-309
    • Holstein, S.A.1    Hohl, R.J.2
  • 17
    • 41049084067 scopus 로고    scopus 로고
    • Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro
    • Idris A, Rojas J, Greig IR, Van't Hof RJ, Ralston SH,. 2008. Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro. Calcif Tissue Int 82: 191-201.
    • (2008) Calcif Tissue Int , vol.82 , pp. 191-201
    • Idris, A.1    Rojas, J.2    Greig, I.R.3    Van'T Hof, R.J.4    Ralston, S.H.5
  • 18
    • 0028556527 scopus 로고
    • Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report
    • WHO Study Group.
    • Kanis J, WHO Study Group. 1994. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. Osteoporosis Int 4: 368-381.
    • (1994) Osteoporosis Int , vol.4 , pp. 368-381
    • Kanis, J.1
  • 19
    • 34250026450 scopus 로고    scopus 로고
    • Farnesyl diphosphate synthase: A novel genotype association with bone mineral density in elderly women
    • DOI 10.1016/j.maturitas.2007.01.005, PII S0378512207000321
    • Levy ME, Parker RA, Ferrell RE, Zmuda JM, Greenspan SL,. 2007. Farnesyl diphosphate synthase: A novel genotype association with bone mineral density in elderly women. Maturitas 57: 247-252. (Pubitemid 46891698)
    • (2007) Maturitas , vol.57 , Issue.3 , pp. 247-252
    • Levy, M.E.1    Parker, R.A.2    Ferrell, R.E.3    Zmuda, J.M.4    Greenspan, S.L.5
  • 21
    • 0031977199 scopus 로고    scopus 로고
    • Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
    • DOI 10.1359/jbmr.1998.13.4.581
    • Luckman S, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ,. 1998. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 13: 581-589. (Pubitemid 28163009)
    • (1998) Journal of Bone and Mineral Research , vol.13 , Issue.4 , pp. 581-589
    • Luckman, S.P.1    Hughes, D.E.2    Coxon, F.P.3    Russell, R.G.G.4    Rogers, M.J.5
  • 24
    • 53349101679 scopus 로고    scopus 로고
    • Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis
    • Marini F, Falchetti A, Silvestri S, Bagger Y, Luzi E, Tanini A, Christiansen C, Brandi ML,. 2008. Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis. Curr Med Res Opin 24: 2609-2615.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2609-2615
    • Marini, F.1    Falchetti, A.2    Silvestri, S.3    Bagger, Y.4    Luzi, E.5    Tanini, A.6    Christiansen, C.7    Brandi, M.L.8
  • 29
    • 58649122908 scopus 로고    scopus 로고
    • Inhibition of osteoblast function in vitro by aminobisphosphonates
    • Orriss I, Key ML, Colston KW, Arnett TR,. 2009. Inhibition of osteoblast function in vitro by aminobisphosphonates. J Cell Biochem 106: 109-118.
    • (2009) J Cell Biochem , vol.106 , pp. 109-118
    • Orriss, I.1    Key, M.L.2    Colston, K.W.3    Arnett, T.R.4
  • 31
    • 33748107691 scopus 로고    scopus 로고
    • Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling
    • DOI 10.1007/s00223-005-0297-z
    • Sher L, Harrison JR, Adams DJ, Kream BE,. 2006. Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Calcif Tissue Int 79: 118-125. (Pubitemid 44306169)
    • (2006) Calcified Tissue International , vol.79 , Issue.2 , pp. 118-125
    • Sher, L.B.1    Harrison, J.R.2    Adams, D.J.3    Kream, B.E.4
  • 33
    • 71849085178 scopus 로고    scopus 로고
    • Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells
    • Takase H, Yano S, Yamaguchi T, Kanazawa I, Hayashi K, Yamamoto M, Yamauchi M, Sugimoto T,. 2009. Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells. Horm Metab Res 41: 861-865.
    • (2009) Horm Metab Res , vol.41 , pp. 861-865
    • Takase, H.1    Yano, S.2    Yamaguchi, T.3    Kanazawa, I.4    Hayashi, K.5    Yamamoto, M.6    Yamauchi, M.7    Sugimoto, T.8
  • 35
    • 9944233982 scopus 로고    scopus 로고
    • Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells
    • DOI 10.1016/j.ab.2004.09.024, PII S0003269704007602
    • Tong H, Holstein SA, Hohl RJ,. 2005. Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. Anal Biochem 336: 51-59. (Pubitemid 39593499)
    • (2005) Analytical Biochemistry , vol.336 , Issue.1 , pp. 51-59
    • Tong, H.1    Holstein, S.A.2    Hohl, R.J.3
  • 39
    • 33748776041 scopus 로고    scopus 로고
    • Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1
    • DOI 10.1016/j.febslet.2006.08.060, PII S0014579306010337
    • Yoshida T, Asanuma M, Grossmann L, Fuse M, Shibata T, Yonekawa T, Tanaka T, Ueno K, Yasuda T, Saito Y, Tatsuno I,. 2006. Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1. FEBS Lett 580: 5203-5207. (Pubitemid 44415791)
    • (2006) FEBS Letters , vol.580 , Issue.22 , pp. 5203-5207
    • Yoshida, T.1    Asanuma, M.2    Grossmann, L.3    Fuse, M.4    Shibata, T.5    Yonekawa, T.6    Tanaka, T.7    Ueno, K.8    Yasuda, T.9    Saito, Y.10    Tatsuno, I.11
  • 40
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang FL, Casey PJ,. 1996. Protein prenylation: Molecular mechanisms and functional consequences. Annu Rev Biochem 65: 241-269. (Pubitemid 26250610)
    • (1996) Annual Review of Biochemistry , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.