Lipid metabolism in subclinical hypothyroidism: Plasma kinetics of triglyceride-rich lipoproteins and lipid transfers to high-density lipoprotein before and after levothyroxine treatment

Thyroid

Volumn 21, Issue 4, 2011, Pages 347-353

  Sigal, Gilbert A ^a   Medeiros Neto, Geraldo ^a   Vinagre, Juliana C ^a   Diament, Jayme ^a   Maranhão, Raul C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ARYLDIALKYLPHOSPHATASE 1; CHOLESTEROL; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; LEVOTHYROXINE; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; THYROTROPIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; EMULSION; ENZYME ACTIVITY; EUTHYROIDISM; FEMALE; HUMAN; HYPOTHYROIDISM; IN VITRO STUDY; KINETICS; LIPID METABOLISM; LIPOLYSIS; METABOLIC CLEARANCE RATE; NANOEMULSION; PARTICLE SIZE; PLASMA; PRIORITY JOURNAL; SUBCLINICAL HYPOTHYROIDISM; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 79954553829     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2010.0313     Document Type: Article

References (27)

1. Arem R, Escalante D 1996 Subclinical hypothyroidism: epi-demiology, diagnoses and significance. Adv Intern Med 41:213-250. (Pubitemid 126816486)
2. Hak AE, Pols HAP, Visser TJ, Drexhage HA, Hofman A, Witteman JCM 2000 Subclinical hypothyroidism is an in-dependent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study. Ann In-tern Med 132:270-278. (Pubitemid 30106257)
3. Walsh JP, Bremner AP, Bulsara MK, O'Leary P, Leedman PJ, Feddema P, Michelangeli V 2005 Subclinical thyroid dys-function as a risk factor for cardiovascular disease. Arch Intern Med 165:2467-2472. (Pubitemid 41720007)
4. Duntas LH, Wartofsky L 2007 Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence? Thyroid 17: 1075-1084. (Pubitemid 350207760)
5. Lekakis J, Papamichael C, Alevizaki M, Piperingos G, Mar-afelia P, Mantzos J, Stamatelopoulos S, Koutras DA 1997 Flow-mediated, endothelium-dependent vasodilation is im-paired in subject with hypothyroidism, borderline hypothyroidism, and high-normal serum thyrotropin (TSH) values. Thyroid 7:411-414. (Pubitemid 27295140)
6. Taddei S, Caraccio N, Virdis A, Dardano A, Versari D, Ghiadoni L, Salvetti D, Ferranini E, Monzani F 2003 Im-paired endothelium-dependent vasodilation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J Clin Endocrinol Metab 88:3731-3737. (Pubitemid 37034521)
7. Surks M, Ortiz E, Daniels G, Sawin C, Col N, Cobin R, Franklyn J, Heshman J, Burman K, Denke M, Gorman C, Cooper R, Weissman N 2004 Subclinical thyroid disease scientific review and guidelines for diagnosis and manage-ment. JAMA 291:228-238. (Pubitemid 38082818)
8. Canaris GJ, Manowitz NR, Mayor G, Ridgway 2000 The Colorado thyroid disease prevalence study. Arch Intern Med 160:526-534. (Pubitemid 30112276)
9. Ginsberg HN 1998 Lipoprotein physiology. Endocrinol Metab Clin North Am 27:503-519. (Pubitemid 28446945)
10. Maranhão RC, Feres MC, Martins MT, Mesquita CH, Tof-foletto O, Vinagre CG, Gianinni SD, Pileggi F 1996 Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease. Atherosclerosis 126:15-25. (Pubitemid 26284014)
11. Yu KC, Cooper AD 2001 Postprandial lipoproteins and atherosclerosis. Front Biosci 6:D332-D354.
12. Mackness MI, Harty D, Bhatnagar D, Winocour PH, Arrol S, Ishola M, Durrington DN 1991 Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent dia-betes mellitus. Atherosclerosis 86:193-199.
13. Lima ES, Maranhão RC 2004 Rapid, simple laser-light-scattering method for HDL particle sizing in whole plasma. Clin Chem 50:1086-1088. (Pubitemid 38725806)
14. Lo Prete AC, Dina CH, Azevedo CH, Puk CG, Lopes NH, Hueb WA, Maranhao RC 2009 In vitro simultaneous transfer of lipids to HDL in coronary artery disease and in statin treatment. Lipids 44:917-924.
15. Kahaly G J 2000 Cardiovascular and atherogenic aspects of subclinical hypothyroidism. Thyroid 10:665-669.
16. Sposito AC, Ventura LI, Vinagre CG, Lemos PA, Quintela E, Santos RD, Carneiro O, Ramires JAF, Maranhão RC 2004 Delayed intravascular catabolism of chylomicron-like emulsions is an independent predictor of coronary artery disease. Atherosclerosis 176:397-403. (Pubitemid 39369532)
17. Groot PH, van Stiphout WA, Krauss XH, Jansen H, van Tol A, van Ramshorst E, Chin-On S, Hofman A, Cresswell SR, Havekes L 1991 Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arteroscler Thromb 11:653-662.
18. Sposito AC, Lemos PA, Santos RD, Hueb W, Vinagre CG, Quintella E, Carneiro O, Chapman MJ, Ramires JA, Mar-anhão RC 2004 Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina undergoing secondary prevention treatment: a long-term follow-up study. J Am Coll Cardiol 43:2225-2232. (Pubitemid 38757589)
19. Wilhelm MG, Cooper AD 2003 Induction of atherosclerosis by human chylomicron remnants: a hypothesis. J Ather-oscler Thromb 10:132-139.
20. Zerbinatti CV, Oliveira HC, Wechesler S, Quintao EC 1991 Independent regulation of chylomicron lipolysis and particle removal rates: effects of insulin and thyroid hormones on the metabolism of artificial chylomicrons. Metabolism 40:1122-1127.
21. Redgrave TG, Snibson DA 1977 Clearance of chylomicrons triacylglycerol and cholesteryl ester from the plasma of streptozotocin-induced diabetic and hypercholesterolemic hypothyroid rats. Metabolism 26:493-503. (Pubitemid 8087158)
22. Mitsuru I, Takamatsu J, Matsuo T, Kameoka K, Kubota S, Fukata S, Tamai H, Miyauchi A, Kuma K, Hanafusa T 2003 Serum concentrations of remnant-like particles in hypothy-roid patients before and after thyroxine replacement. Clin Endocrinol 58:621-626. (Pubitemid 36566805)
23. Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJP, Myant NB 1981 Defects of receptor-mediated low den-sity lipoprotein catabolism in homozygous familial hy-percholesterolimia and hypothyroidism in vivo. Proc Natl Acad Sci USA 78:2591-2595. (Pubitemid 11067253)
24. Weintraub M, Grosskopf I, Trostanesky Y, Charach G, Ru-binstein A, Stern N 1999 Thyroxine replacement therapy en-hances clearance of chylomicrons remnants in patients with hypothyroidism. J Clin Endocrinol Metab 84:2532-2536.
25. Tanaci N, Ertugrul DT, Sahin M, Yucel M, Olcay I, Demirag NG, Gursoy A 2006 Postprandial lipemia as a risk factor for cardiovascular disease in patients with hypothyroidism. Endocrine 29:451-456. (Pubitemid 44358835)
26. Marmillot P, Patel S, Lakshman MR 2007 Reverse cholesterol transport is regulated by varying fatty acyl chain saturation and sphingomyelin content in reconstituted high-density li-poproteins. Metabolism 56:251-259. (Pubitemid 46074073)
27. Kebapcilar L, ComLekci A, Tuncel P, Solak A, Secil M, Gencel O, Sahin M, Sari I, Yesil S 2010 Effect of levothyr-oxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism. Med Sci Monit 16:CR41-CR47.