A prospective, randomized controlled trial on the efficacy of fractional photothermolysis on scar remodeling

Lasers in Surgery and Medicine

Volumn 43, Issue 4, 2011, Pages 265-272

  Lin, Jennifer Y ^a,b,e   Warger II, William C ^a   Izikson, Leonid ^a   Anderson, R Rox ^a,c   Tannous, Zeina ^a,c,d  

^a Wellman Center for Photomedicine   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Veterans Affairs Boston Health System   (United States)

^e NONE   (United States)

Author keywords

clinical trial; hypertrophic scar; laser resurfacing; wound healing

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; FRACTIONAL PHOTOTHERMOLYSIS; HUMAN; HYPERTROPHIC SCAR; LASER; MALE; NON ABLATIVE FRACTIONAL RESURFACING; PATIENT SATISFACTION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCAR; TREATMENT OUTCOME;

ADULT; AGED; CHI-SQUARE DISTRIBUTION; CICATRIX, HYPERTROPHIC; ESTHETICS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; OBSERVER VARIATION; PHOTOTHERAPY; PROSPECTIVE STUDIES; REFERENCE VALUES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 79954540048     PISSN: 01968092     EISSN: 10969101     Source Type: Journal    
DOI: 10.1002/lsm.21061     Document Type: Article

References (38)

1. Wolfram D, Tzankov A, Pulzl P, Piza-Katzer H,. Hypertrophic scars and keloids-a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 2009; 35 (2): 171-181.
2. Alster TS, Williams CM,. Treatment of keloid sternotomy scars with 585 nm flashlamp-pumped pulsed-dye laser. Lancet 1995; 345 (8959): 1198-1200.
3. Manuskiatti W, Wanitphakdeedecha R, Fitzpatrick RE,. Effect of pulse width of a 595-nm flashlamp-pumped pulsed dye laser on the treatment response of keloidal and hypertrophic sternotomy scars. Dermatol Surg 2007; 33 (2): 152-161. (Pubitemid 46208105)
4. Nouri K, Jimenez GP, Harrison-Balestra C, Elgart GW,. 585-nm pulsed dye laser in the treatment of surgical scars starting on the suture removal day. Dermatol Surg 2003; 29 (1): 65-73; discussion 73. (Pubitemid 36114732)
5. Sherman R, Rosenfeld H,. Experience with the Nd:YAG laser in the treatment of keloid scars. Ann Plast Surg 1988; 21 (3): 231-235.
6. Alster TS, Kurban AK, Grove GL, Grove MJ, Tan OT,. Alteration of argon laser-induced scars by the pulsed dye laser. Lasers Surg Med 1993; 13 (3): 368-373. (Pubitemid 23184683)
7. Alster TS, Nanni CA,. Pulsed dye laser treatment of hypertrophic burn scars. Plast Reconstr Surg 1998; 102 (6): 2190-2195. (Pubitemid 28518549)
8. Kuo YR, Wu WS, Jeng SF, Wang FS, Huang HC, Lin CZ, Yang KD,. Suppressed TGF-beta1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment. Lasers Surg Med 2005; 36 (1): 38-42. (Pubitemid 40224029)
9. Kuo YR, Wu WS, Jeng SF, Huang HC, Yang KD, Sacks JM, Wang FS,. Activation of ERK and p38 kinase mediated keloid fibroblast apoptosis after flashlamp pulsed-dye laser treatment. Lasers Surg Med 2005; 36 (1): 31-37. (Pubitemid 40224028)
10. Lee DH, Choi YS, Min SU, Yoon MY, Suh DH,. Comparison of a 585-nm pulsed dye laser and a 1064-nm Nd:YAG laser for the treatment of acne scars: A randomized split-face clinical study. J Am Acad Dermatol 2009; 60 (5): 801-807.
11. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR,. Fractional photothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004; 34 (5): 426-438. (Pubitemid 38890753)
12. Behroozan DS, Goldberg LH, Dai T, Geronemus RG, Friedman PM,. Fractional photothermolysis for the treatment of surgical scars: A case report. J Cosmet Laser Ther 2006; 8 (1): 35-38.
13. Glaich AS, Rahman Z, Goldberg LH, Friedman PM,. Fractional resurfacing for the treatment of hypopigmented scars: A pilot study. Dermatol Surg 2007; 33 (3): 289-294; discussion 293-294. (Pubitemid 46328221)
14. Hasegawa T, Matsukura T, Mizuno Y, Suga Y, Ogawa H, Ikeda S,. Clinical trial of a laser device called fractional photothermolysis system for acne scars. J Dermatol 2006; 33 (9): 623-627. (Pubitemid 44337307)
15. Rahman Z, Alam M, Dover JS,. Fractional Laser treatment for pigmentation and texture improvement. Skin Therapy Lett 2006; 11 (9): 7-11.
16. Haedersdal M, Moreau KE, Beyer DM, Nymann P, Alsbjorn B,. Fractional nonablative 1540 nm laser resurfacing for thermal burn scars: A randomized controlled trial. Lasers Surg Med 2009; 41 (3): 189-195.
17. Waibel J, Beer K,. Fractional laser resurfacing for thermal burns. J Drugs Dermatol 2008; 7 (1): 59-61.
18. Haedersdal M,. Fractional ablative CO(2) laser resurfacing improves a thermal burn scar. J Eur Acad Dermatol Venereol 2009; 23 (11): 1340-1341.
19. Waibel J, Beer K,. Ablative fractional laser resurfacing for the treatment of a third-degree burn. J Drugs Dermatol 2009; 8 (3): 294-297.
20. Yun S, Tearney G, de Boer J, Iftimia N, Bouma B,. High-speed optical frequency-domain imaging. Opt Express 2003; 11 (22): 2953-2963.
21. Laubach HJ, Tannous Z, Anderson RR, Manstein D,. Skin responses to fractional photothermolysis. Lasers Surg Med 2006; 38 (2): 142-149.
22. Tearney GJ, Waxman S, Shishkov M, Vakoc BJ, Suter MJ, Freilich MI, Desjardins AE, Oh WY, Bartlett LA, Rosenberg M, Bouma BE,. Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging. JACC 2008; 1 (6): 752-761.
23. Suter MJ, Vakoc BJ, Yachimski PS, Shishkov M, Lauwers GY, Mino-Kenudson M, Bouma BE, Nishioka NS, Tearney GJ,. Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging. Gastrointest Endosc 2008; 68 (4): 745-753.
24. Friedman PM, Skover GR, Payonk G, Geronemus RG,. Quantitative evaluation of nonablative laser technology. Semin Cutan Med Surg 2002; 21 (4): 266-273. (Pubitemid 36055625)
25. Purschke M, Laubach HJ, Anderson RR, Manstein D,. Thermal injury causes DNA damage and lethality in unheated surrounding cells: Active thermal bystander effect. J Invest Dermatol 2010; 130 (1): 86-92.
26. Nouri K, Rivas MP, Stevens M, Ballard CJ, Singer L, Ma F, Vejjabhinanta V, Elsaie ML, Elgart GW,. Comparison of the effectiveness of the pulsed dye laser 585 nm versus 595 nm in the treatment of new surgical scars. Lasers Med Sci 2009; 24 (5): 801-810.
27. Alster TS,. Improvement of erythematous and hypertrophic scars by the 585-nm flashlamp-pumped pulsed dye laser. Ann Plast Surg 1994; 32 (2): 186-190. (Pubitemid 24057134)
28. Dierickx C, Goldman MP, Fitzpatrick RE,. Laser treatment of erythematous/hypertrophic and pigmented scars in 26 patients. Plast Reconstr Surg 1995; 95 (1): 84-90; discussion 91-92.
29. Shakespeare PG, Tiernan E, Dewar AE, Hambleton J,. Using the pulsed dye laser to influence scar formation after breast reduction surgery: A preliminary report. Ann Plast Surg 2000; 45 (4): 357-368.
30. Kono T, Ercocen AR, Nakazawa H, Honda T, Hayashi N, Nozaki M,. The flashlamp-pumped pulsed dye laser (585 nm) treatment of hypertrophic scars in Asians. Ann Plast Surg 2003; 51 (4): 366-371. (Pubitemid 37210748)
31. Chan HH, Wong DS, Ho WS, Lam LK, Wei W,. The use of pulsed dye laser for the prevention and treatment of hypertrophic scars in chinese persons. Dermatol Surg 2004; 30 (7): 987-994; discussion 994. (Pubitemid 38890906)
32. Kuo YR, Wu WS, Wang FS,. Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway. Lasers Surg Med 2007; 39 (4): 358-364.
33. Asilian A, Darougheh A, Shariati F,. New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 2006; 32 (7): 907-915. (Pubitemid 44034368)
34. Alster T,. Laser scar revision: Comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids. Dermatol Surg 2003; 29 (1): 25-29. (Pubitemid 36114725)
35. Manuskiatti W, Fitzpatrick RE,. Treatment response of keloidal and hypertrophic sternotomy scars: Comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 2002; 138 (9): 1149-1155. (Pubitemid 35025686)
36. Fitzpatrick RE,. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 1999; 25 (3): 224-232. (Pubitemid 29146991)
37. Tierney E, Mahmoud BH, Srivastava D, Ozog D, Kouba DJ,. Treatment of surgical scars with nonablative fractional laser versus pulsed dye laser: A randomized controlled trial. Dermatol Surg 2009; 35 (8): 1172-1180.
38. Niwa AB, Mello AP, Torezan LA, Osorio N,. Fractional photothermolysis for the treatment of hypertrophic scars: Clinical experience of eight cases. Dermatol Surg 2009; 35 (5): 773-777; discussion 777-778.