The anti-metastatic nm23-1 gene is needed for the final step of mammary duct maturation of the mouse nipple

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Deplagne, Camille ^a,b   Peuchant, Evelyne ^a,b   Moranvillier, Isabelle ^a,b   Dubus, Pierre ^b   Dabernat, Sandrine ^a,b  

^a INSERM ^*  (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE A; NUCLEOSIDE DIPHOSPHATE KINASE NM23; NUCLEOSIDE DIPHOSPHATE KINASE NM23 1; UNCLASSIFIED DRUG; NME1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST DEVELOPMENT; BREAST DUCT; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE; GENE DELETION; GROWTH RETARDATION; LACTATION; MAMMARY GLAND; MAMMARY GLAND FUNCTION; MILK EJECTION; MILK PRODUCTION; MOUSE; NIPPLE; NM23 1 GENE; NONHUMAN; PHENOTYPE; ANIMAL; EPITHELIUM; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; UDDER; WESTERN BLOTTING;

MUS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; EPITHELIUM; FEMALE; HUMANS; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NIPPLES; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; POLYMERASE CHAIN REACTION;

EID: 79954521960     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018645     Document Type: Article

References (39)

1. Boissan M, Dabernat S, Peuchant E, Schlattner U, Lascu I, et al. (2009) The mammalian Nm23/NDPK family: from metastasis control to cilia movement. Mol Cell Biochem 329: 51-62.
2. Steeg PS, Bevilacqua G, Sobel ME, Liotta LA, (1991) Identification and characterization of differentially expressed genes in tumor metastasis: the nm23 gene. Basic Life Sci 57: 355-360; discussion 360-351.
3. Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, et al. (1988) Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 80: 200-204.
4. Steeg PS, Horak CE, Miller KD, (2008) Clinical-translational approaches to the Nm23-H1 metastasis suppressor. Clin Cancer Res 14: 5006-5012.
5. Boissan M, Wendum D, Arnaud-Dabernat S, Munier A, Debray M, et al. (2005) Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma. J Natl Cancer Inst 97: 836-845.
6. Palacios F, Schweitzer JK, Boshans RL, D'Souza-Schorey C, (2002) ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol 4: 929-936.
7. Murakami M, Meneses PI, Lan K, Robertson ES, (2008) The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration. Cancer Biol Ther 7: 677-688.
8. Murakami M, Meneses PI, Knight JS, Lan K, Kaul R, et al. (2008) Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1. Int J Cancer 123: 500-510.
9. Fournier HN, Albiges-Rizo C, Block MR, (2003) New insights into Nm23 control of cell adhesion and migration. J Bioenerg Biomembr 35: 81-87.
10. Timmons L, Shearn A, (2000) Role of AWD/nucleoside diphosphate kinase in Drosophila development. J Bioenerg Biomembr 32: 293-300.
11. Hama H, Almaula N, Lerner CG, Inouye S, Inouye M, (1991) Nucleoside diphosphate kinase from Escherichia coli; its overproduction and sequence comparison with eukaryotic enzymes. Gene 105: 31-36.
12. Fukuchi T, Nikawa J, Kimura N, Watanabe K, (1993) Isolation, overexpression and disruption of a Saccharomyces cerevisiae YNK gene encoding nucleoside diphosphate kinase. Gene 129: 141-146.
13. Miller JH, Funchain P, Clendenin W, Huang T, Nguyen A, et al. (2002) Escherichia coli strains (ndk) lacking nucleoside diphosphate kinase are powerful mutators for base substitutions and frameshifts in mismatch-repair-deficient strains. Genetics 162: 5-13.
14. Arnaud-Dabernat S, Bourbon PM, Dierich A, Le Meur M, Daniel JY, (2003) Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene. J Bioenerg Biomembr 35: 19-30.
15. Masse K, Dabernat S, Bourbon PM, Larou M, Amrein L, et al. (2002) Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs. Gene 296: 87-97.
16. Postel EH, Wohlman I, Zou X, Juan T, Sun N, et al. (2009) Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo. Dev Dyn 238: 775-787.
17. Lakso M, Steeg PS, Westphal H, (1992) Embryonic expression of nm23 during mouse organogenesis. Cell Growth Differ 3: 873-879.
18. Howlett AR, Petersen OW, Steeg PS, Bissell MJ, (1994) A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J Natl Cancer Inst 86: 1838-1844.
19. Steeg PS, (2004) Perspectives on classic article: metastasis suppressor genes. J Natl Cancer Inst 96: E4.
20. Green KA, Streuli CH, (2004) Apoptosis regulation in the mammary gland. Cell Mol Life Sci 61: 1867-1883.
21. Humphreys RC, Krajewska M, Krnacik S, Jaeger R, Weiher H, et al. (1996) Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development 122: 4013-4022.
22. Hynes NE, Cella N, Wartmann M, (1997) Prolactin mediated intracellular signaling in mammary epithelial cells. J Mammary Gland Biol Neoplasia 2: 19-27.
23. Kimura T, Ito Y, Einspanier A, Tohya K, Nobunaga T, et al. (1998) Expression and immunolocalization of the oxytocin receptor in human lactating and non-lactating mammary glands. Hum Reprod 13: 2645-2653.
24. Toyoshima Y, Ohsako S, Nagano R, Matsumoto M, Hidaka S, et al. (1998) Histological changes in mouse nipple tissue during the reproductive cycle. J Vet Med Sci 60: 405-411.
25. Mahler B, Gocken T, Brojan M, Childress S, Spandau DF, et al. (2004) Keratin 2e: a marker for murine nipple epidermis. Cells Tissues Organs 176: 169-177.
26. Jin L, Liu G, Zhang CH, Lu CH, Xiong S, et al. (2009) Nm23-H1 regulates the proliferation and differentiation of the human chronic myeloid leukemia K562 cell line: a functional proteomics study. Life Sci 84: 458-467.
27. Choudhuri T, Murakami M, Kaul R, Sahu SK, Mohanty S, et al. Nm23-H1 can induce cell cycle arrest and apoptosis in B cells. Cancer Biol Ther 9.
28. Hartsough MT, Steeg PS, (2000) Nm23/nucleoside diphosphate kinase in human cancers. J Bioenerg Biomembr 32: 301-308.
29. Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO, (2000) The human Nm23/nucleoside diphosphate kinases. J Bioenerg Biomembr 32: 247-258.
30. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J, (2003) Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 112: 659-672.
31. Jung H, Seong HA, Ha H, (2008) Direct interaction between NM23-H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity. J Biol Chem 283: 32669-32679.
32. Verjans E, Noetzel E, Bektas N, Schutz AK, Lue H, et al. (2009) Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer 9: 230.
33. Jung H, Seong HA, Ha H, (2007) NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. J Biol Chem 282: 35293-35307.
34. Palmer CA, Neville MC, Anderson SM, McManaman JL, (2006) Analysis of lactation defects in transgenic mice. J Mammary Gland Biol Neoplasia 11: 269-282.
35. Zhao L, Roche PJ, Gunnersen JM, Hammond VE, Tregear GW, et al. (1999) Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology 140: 445-453.
36. Krajnc-Franken MA, van Disseldorp AJ, Koenders JE, Mosselman S, van Duin M, et al. (2004) Impaired nipple development and parturition in LGR7 knockout mice. Mol Cell Biol 24: 687-696.
37. Kobayashi T, Kronenberg HM, Foley J, (2005) Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation. Dev Dyn 233: 794-803.
38. Toyoshima Y, Ohsako S, Matsumoto M, Hidaka S, Nishinakagawa H, (1998) Histological and morphometrical studies on the rat nipple during the reproductive cycle. Exp Anim 47: 29-36.
39. Mailleux AA, Overholtzer M, Brugge JS, (2008) Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle 7: 57-62.