Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 3, 2011, Pages

  Hannibal, Jens ^a   Hsiung, Hansen M ^b   Fahrenkrug, Jan ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Circadian rhythms; Entrainment; Jetlag; Neurotransmitter; Running wheels; Telemetry

Indexed keywords

VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2;

ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORE TEMPERATURE; DARKNESS; EXPERIMENTAL TEST; FEMALE; HEART RATE; HORMONE RELEASE; LIGHT; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SLEEP WAKING CYCLE; SUPRACHIASMATIC NUCLEUS; TELEMETRY; WHEEL RUNNING;

ANIMALS; BODY TEMPERATURE REGULATION; CIRCADIAN RHYTHM; FEMALE; GENOTYPE; HEART RATE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PHENOTYPE; PHOTOPERIOD; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE, TYPE II; RUNNING; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS; TELEMETRY; TIME FACTORS;

EID: 79954510531     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00599.2010     Document Type: Article

References (34)

1. Abrahamson EE, Moore RY. Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections. Brain Res 916: 172-191, 2001.
2. Asnicar MA, Koster A, Heiman ML, Tinsley F, Smith DP, Galbreath E, Fox N, Ma YL, Blum WF, Hsiung HM. Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate. Endocrinology 143: 3994-4006, 2002.
3. Aton SJ, Colwell CS, Harmar AJ, Waschek J, Herzog ED. Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nat Neurosci 8: 476-483, 2005.
4. Bechtold DA, Brown TM, Luckman SM, Piggins HD. Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling. Am J Physiol Regul Integr Comp Physiol 294: R344-R351, 2008.
5. Carneiro BT, Araujo JF. The food-entrainable oscillator: a network of interconnected brain structures entrained by humoral signals? Chronobiol Int 26: 1273-1289, 2009.
6. Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X, Waschek JA. Disrupted circadian rhythms in VIP and PHI deficient mice. Am J Physiol Regul Integr Comp Physiol 285: R939-R949, 2003.
7. de Visser L, van den Bos R, Stoker AK, Kas MJ, Spruijt BM. Effects of genetic background and environmental novelty on wheel running as a rewarding behavior in mice. Behav Brain Res 177: 290-297, 2007.
8. Doyle SE, Yoshikawa T, Hillson H, Menaker M. Retinal pathways influence temporal niche. Proc Natl Acad Sci USA 105: 13133-13138, 2008.
9. Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev 90: 1063-1102, 2010.
10. Hannibal J, Brabet P, Jamen F, Nielsen HS, Journot L, Fahrenkrug J. Dissociation between light induced phase shift of the circadian rhythm and clock gene expression in mice lacking the PACAP type 1 receptor (PAC1). J Neurosci 21: 4883-4890, 2001.
11. Harmar AJ, Marston HM, Shen S, Spratt C, West KM, Sheward WJ, Morrison CF, Dorin JR, Piggins HD, Reubi JC, Kelly JS, Maywood ES, Hastings MH. The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell 109: 497-508, 2002.
12. Harmar AJ, Sheward WJ, Morrison CF, Waser B, Gugger M, Reubi JC. Distribution of the VPAC2 receptor in peripheral tissues of the mouse. Endocrinology 145: 1203-1210, 2004.
13. Hughes AT, Fahey B, Cutler DJ, Coogan AN, Piggins HD. Aberrant gating of photic input to the suprachiasmatic circadian pacemaker of mice lacking the VPAC2 receptor. J Neurosci 24: 3522-3526, 2004.
14. Hughes AT, Piggins HD. Behavioral responses of Vipr2-/-mice to light. J Biol Rhythms 23: 211-219, 2008.
15. Janssen BJ, Tyssen CM, Duindam H, Rietveld WJ. Suprachiasmatic lesions eliminate 24-h blood pressure variability in rats. Physiol Behav 55: 307-311, 1994.
16. Kalamatianos T, Kallo I, Piggins HD, Coen CW. Expression of VIP and/or PACAP receptor mRNA in peptide synthesizing cells within the suprachiasmatic nucleus of the rat and in its efferent target sites. J Comp Neurol 475: 19-35, 2004.
17. Kuroda H, Fukushima M, Nakai M, Katayama T, Murakami N. Daily wheel running activity modifies the period of free-running rhythm in rats via intergeniculate leaflet. Physiol Behav 61: 633-637, 1997.
18. Maywood ES, O'Neill JS, Reddy AB, Chesham JE, Prosser HM, Kyriacou CP, Godinho SI, Nolan PM, Hastings MH. Genetic and molecular analysis of the central and peripheral circadian clockwork of mice. Cold Spring Harb Symp Quant Biol 72: 85-94, 2007.
19. Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, Mc-Mahon DG, Harmar AJ, Okamura H, Hastings MH. Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling. Curr Biol 16: 599-605, 2006.
20. Mrosovsky N. Masking: history definitions, measurement. Chronobiol Int 16: 415-429, 1999.
21. Pantazopoulos H, Dolatshad H, Davis FC. Chronic stimulation of the hypothalamic vasoactive intestinal peptide receptor lengthens circadian period in mice and hamsters. Am J Physiol Regul Integr Comp Physiol 299: R379-R385, 2010.
22. Power A, Hughes AT, Samuels RE, Piggins HD. Rhythm-promoting actions of exercise in mice with deficient neuropeptide signaling. J Biol Rhythms 25: 235-246, 2010.
23. Redlin U, Mrosovsky N. Masking by light in hamsters with SCN lesions. J Comp Physiol [A] 184: 439-448, 1999.
24. Refinetti R. The circadian rhythm of body temperature. Front Biosci 15: 564-594, 2010.
25. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 418: 935-941, 2002.
26. Saleh MA, Winget CM. Effect of suprachiasmatic lesions on diurnal heart rate rhythm in the rat. Physiol Behav 19: 561-564, 1977.
27. Sano H, Hayashi H, Makino M, Takezawa H, Hirai M, Saito H, Ebihara S. Effects of suprachiasmatic lesions on circadian rhythms of blood pressure, heart rate and locomotor activity in the rat. Jpn Circ J 59: 565-573, 1995.
28. Schroeder A, Loh DH, Jordan MC, Roos KP, Colwell CS. Circadian regulation of cardiovascular function: a role for vasoactive intestinal peptide. Am J Physiol Heart Circ Physiol. In press.
29. Sei H, Oishi K, Chikahisa S, Kitaoka K, Takeda E, Ishida N. Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice. Endocrinology 149: 3576-3580, 2008.
30. Shen S, Spratt C, Sheward WJ, Kallo I, West K, Morrison CF, Coen CW, Marston HM, Harmar AJ. Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice. Proc Natl Acad Sci USA 97: 11575-11580, 2000.
31. Sheward WJ, Maywood ES, French KL, Horn JM, Hastings MH, Seckl JR, Holmes MC, Harmar AJ. Entrainment to feeding but not to light: circadian phenotype of VPAC2 receptor-null mice. J Neurosci 27: 4351-4358, 2007.
32. Sheward WJ, Naylor E, Knowles-Barley S, Armstrong JD, Brooker GA, Seckl JR, Turek FW, Holmes MC, Zee PC, Harmar AJ. Circadian control of mouse heart rate and blood pressure by the suprachiasmatic nuclei: behavioral effects are more significant than direct outputs. PLoS ONE 5: e9783, 2010.
33. van der Veen DR, Minh NL, Gos P, Arneric M, Gerkema MP, Schibler U. Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci USA 103: 3393-3398, 2006.
34. Vukolic A, Antic V, Van Vliet BN, Yang Z, Albrecht U, Montani JP. Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms. Am J Physiol Regul Integr Comp Physiol 298: R627-R634, 2010.