Repeated blood instillation into the airway of the horse does not cause pulmonary fibrosis

Equine Veterinary Journal

Volumn 43, Issue 3, 2011, Pages 354-358

  Williams, K J ^a   Derksen, F J ^a   Defeijter Rupp, H L ^a   Robinson, N E ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Autologous blood; Exercise induced pulmonary haemorrhage; Fibrosis; Horse

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; BRONCHIOLITIS OBLITERANS; HORSE; HORSE DISEASE; LUNG FIBROSIS; PATHOLOGY;

ANIMALS; BRONCHIOLITIS OBLITERANS; HORSE DISEASES; HORSES; PULMONARY FIBROSIS;

EQUIDAE;

EID: 79954496570     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00163.x     Document Type: Article

References (17)

1. Cordier, J.F. (2000) Organising pneumonia. Thorax 55, 318-328.
2. Derksen, F.J., Williams, K.J., Uhal, B.D., Slocombe, R.F., de Feijter-Rupp, H., Eberhart, S., Berney, C. and Robinson, N. (2007) Pulmonary response to airway instillation of autologous blood in horses. Equine vet. J. 39, 334-339.
3. Howell, D.C., Laurent, G.J. and Chambers, R.C. (2002) Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem. Soc. Trans. 30, 211-216.
4. Mackman, N., Tilley, R.E. and Key, N.S. (2007) Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler. Thromb. Vasc. Biol. 27, 1687-1693.
5. Manohar, M. (1993) Pulmonary artery wedge pressure increases with high-intensity exercise in horses. Am. J. vet. Res. 54, 142-146.
6. Manohar, M. and Goetz, T.E. (1996) Pulmonary vascular pressures of exercising thoroughbred horses with and without endoscopic evidence of EIPH. J. appl. Physiol. 81, 1589-1593.
7. Manohar, M., Hutchens, E. and Coney, E. (1993) Pulmonary haemodynamics in the exercising horse and their relationship to exercise-induced pulmonary haemorrhage. Br. vet. J. 149, 419-428.
8. McKane, S.A. and Slocombe, R.F. (2002) Alveolar fibrosis and changes in equine lung morphometry in response to intrapulmonary blood. Equine vet. J., Suppl. 34, 451-458.
9. Mercer, R.R., Russell, M.L. and Crapo, J.D. (1994) Alveolar septal structure in different species. J. appl. Physiol. 77, 1060-1066.
10. Milman, N. and Pedersen, F.M. (1998) Idiopathic pulmonary haemosiderosis. Epidemiology, pathogenic aspects and diagnosis. Respir. Med. 92, 902-907.
11. O'Callaghan, M.W., Pascoe, J.R., Tyler, W.S. and Mason, D.K. (1987) Exercise-induced pulmonary haemorrhage in the horse: Results of a detailed clinical, post mortem and imaging study. V. Microscopic observations. Equine vet. J. 19, 411-418.
12. Oikawa, M. (1999) Exercise-induced haemorrhagic lesions in the dorsocaudal extremities of the caudal lobes of the lungs of young thoroughbred horses. J. comp. Pathol. 121, 339-347.
13. Sara, A.G., Hamdan, A.J., Hanaa, B. and Nawaz, K.A. (2008) Bronchiolitis obliterans organizing pneumonia: Pathogenesis, clinical features, imaging and therapy review. Ann. Thorac. Med. 3, 67-75.
14. Scotton, C.J., Krupiczojc, M.A., Konigshoff, M., Mercer, P.F., Lee, Y.C., Kaminski, N., Morser, J., Post, J.M., Maher, T.M., Nicholson, A.G., Moffatt, J.D., Laurent, G.J., Derian, C.K., Eickelberg, O. and Chambers, R.C. (2009) Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J. clin. Invest. 119, 2550-2563.
15. van Belle, G., Fisher, L.D., Heagerty, P.J. and Lumley, T. (2004) Biostastics, 2nd edn., Wiley, Hoboken. p 179.
16. White, K.A. and Ruth-Sahd, L.A. (2007) Bronchiolitis obliterans organizing pneumonia. Crit. Care Nurse 27, 53-66; quiz 67.
17. Williams, K.J., Derksen, F.J., de Feijter-Rupp, H., Pannirselvam, R.R., Steel, C.M. and Robinson, N.E. (2008) Regional pulmonary veno-occlusion: A newly identified lesion of equine exercise-induced pulmonary hemorrhage. Vet. Pathol. 45, 316-326.