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Volumn 6, Issue 2, 2011, Pages 246-257

Emerging therapies in the treatment of locally advanced squamous cell cancers of head and neck

Author keywords

Antiangiogenic therapies; Cetuximab; Epidermal growth factor inhibitors; Intensity modulated radiation therapy; Vascular endothelial growth factors

Indexed keywords

ADENOVIRUS VECTOR; AMIFOSTINE; BEVACIZUMAB; CARBOPLATIN; CEDIRANIB; CETUXIMAB; CISPLATIN; DNA VACCINE; DOCETAXEL; ERLOTINIB; FLUOROURACIL; GEFITINIB; LAPATINIB; LONAFARNIB; MITOMYCIN C; PACLITAXEL; PEMETREXED; PROTEIN P53; SORAFENIB; SUNITINIB; VANDETANIB;

EID: 79954470620     PISSN: 15748928     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489211795328477     Document Type: Article
Times cited : (9)

References (101)
  • 2
    • 18944395784 scopus 로고    scopus 로고
    • State-of-the-art management of locally advanced head and neck cancer
    • Seiwert TY, Cohen EE. State-of-the-art management of locally advanced head and neck cancer. Br J Cancer 2005; 92: 1341-8.
    • (2005) Br J Cancer , vol.92 , pp. 1341-1348
    • Seiwert, T.Y.1    Cohen, E.E.2
  • 3
    • 0037215106 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor in head and neck cancer
    • Ford AC, Grandis JR. Targeting epidermal growth factor receptor in head and neck cancer. Head Neck 2003; 25: 67-73.
    • (2003) Head Neck , vol.25 , pp. 67-73
    • Ford, A.C.1    Grandis, J.R.2
  • 4
    • 0037208591 scopus 로고    scopus 로고
    • An Intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer
    • Adelstein DJ, Li Y, Adams GL, Wagner H Jr, Kish JA, Ensley JF, et al. An Intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 2003; 21: 92-8.
    • (2003) J Clin Oncol , vol.21 , pp. 92-98
    • Adelstein, D.J.1    Li, Y.2    Adams, G.L.3    Wagner Jr., H.4    Kish, J.A.5    Ensley, J.F.6
  • 5
    • 3042701812 scopus 로고    scopus 로고
    • Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy In advanced-stage oropharynx carcinoma
    • Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy In advanced-stage oropharynx carcinoma. J Clin Oncol 2004; 22: 69-76.
    • (2004) J Clin Oncol , vol.22 , pp. 69-76
    • Denis, F.1    Garaud, P.2    Bardet, E.3    Alfonsi, M.4    Sire, C.5    Germain, T.6
  • 6
    • 0029900724 scopus 로고    scopus 로고
    • Larynx preservation in pyriform sinus cancer: Preliminary results of a European Organization for Research and Treatment of Cancer phase III trial
    • Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T. Larynx preservation in pyriform sinus cancer: Preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. J Natl Cancer Inst 1996; 88: 890-9.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 890-899
    • Lefebvre, J.L.1    Chevalier, D.2    Luboinski, B.3    Kirkpatrick, A.4    Collette, L.5    Sahmoud, T.6
  • 8
    • 0028158540 scopus 로고
    • Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer
    • th, Murthy AK, Vannetzel JM, Colin P, Dray M, Caldarelli DD, et al. Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer. J Clin Oncol 1994; 12: 385-95.
    • (1994) J Clin Oncol , vol.12 , pp. 385-395
    • Taylor IV, S.G.1    Murthy, A.K.2    Vannetzel, J.M.3    Colin, P.4    Dray, M.5    Caldarelli, D.D.6
  • 11
    • 27444444425 scopus 로고    scopus 로고
    • Neck dissections: Radical to conservative
    • Harish K. Neck dissections: Radical to conservative. World J Surg Oncol 2005; 3: 21.
    • (2005) World J Surg Oncol , vol.3 , pp. 21
    • Harish, K.1
  • 12
    • 0031659058 scopus 로고    scopus 로고
    • Altered fractionation trials in head and neck cancer
    • Ang KK. Altered fractionation trials in head and neck cancer. Semin Radiat Oncol 1998; 8: 230-6.
    • (1998) Semin Radiat Oncol , vol.8 , pp. 230-236
    • Ang, K.K.1
  • 13
    • 18544409287 scopus 로고    scopus 로고
    • A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003
    • Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000; 48: 7-16.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 7-16
    • Fu, K.K.1    Pajak, T.F.2    Trotti, A.3    Jones, C.U.4    Spencer, S.A.5    Phillips, T.L.6
  • 14
    • 33748938009 scopus 로고    scopus 로고
    • Continuous accelerated 7-days a-week radiotherapy for head-and-neck cancer: Long-term results of phase III clinical trial
    • Skladowski K, Maciejewski B, Golen M, Tarnawski R, Slosarek K, Suwinski R, et al. Continuous accelerated 7-days a-week radiotherapy for head-and-neck cancer: Long-term results of phase III clinical trial. Int J Radiat Oncol Biol Phys 2006; 66: 706-13.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 706-713
    • Skladowski, K.1    Maciejewski, B.2    Golen, M.3    Tarnawski, R.4    Slosarek, K.5    Suwinski, R.6
  • 15
    • 33745524904 scopus 로고    scopus 로고
    • Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: A GORTEC trial
    • Bourhis J, Lapeyre M, Tortochaux J, Rives M, Aghili M, Bourdin S, et al. Phase III randomized trial of very accelerated radiation therapy compared with conventional radiation therapy in squamous cell head and neck cancer: A GORTEC trial. J Clin Oncol 2006; 24: 2873-8.
    • (2006) J Clin Oncol , vol.24 , pp. 2873-2878
    • Bourhis, J.1    Lapeyre, M.2    Tortochaux, J.3    Rives, M.4    Aghili, M.5    Bourdin, S.6
  • 16
    • 33747881607 scopus 로고    scopus 로고
    • Hyperfractionated or accelerated radiotherapy in head and neck cancer: A meta-analysis
    • Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: A meta-analysis. Lancet 2006; 368: 843-54.
    • (2006) Lancet , vol.368 , pp. 843-854
    • Bourhis, J.1    Overgaard, J.2    Audry, H.3    Ang, K.K.4    Saunders, M.5    Bernier, J.6
  • 17
    • 56349112679 scopus 로고    scopus 로고
    • Phase II randomized trial of surgery followed by chemoradiation plus cetuximab for high-risk squamous cell carcinoma of the head and neck (RTOG 0234)
    • Harari, PM, Harris J, Kies MS, Myers JN, Machtay M, Rotman MZ, et al. Phase II randomized trial of surgery followed by chemoradiation plus cetuximab for high-risk squamous cell carcinoma of the head and neck (RTOG 0234). Int J Radiat Oncol Biol Phys 2007; 69 (Suppl3): S13-S13.
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , Issue.SUPPL. 3
    • Harari, P.M.1    Harris, J.2    Kies, M.S.3    Myers, J.N.4    Machtay, M.5    Rotman, M.Z.6
  • 18
    • 10044289431 scopus 로고    scopus 로고
    • Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT?
    • Eisbruch A, Schwartz M, Rasch C, Vineberg K, Damen E, Van As CJ, et al. Dysphagia and aspiration after chemoradiotherapy for head-and-neck cancer: Which anatomic structures are affected and can they be spared by IMRT? Int J Radiat Oncol Biol Phys 2004; 60: 1425-39.
    • (2004) Int J Radiat Oncol Biol Phys , vol.60 , pp. 1425-1439
    • Eisbruch, A.1    Schwartz, M.2    Rasch, C.3    Vineberg, K.4    Damen, E.5    van As, C.J.6
  • 19
    • 34547416556 scopus 로고    scopus 로고
    • How much radiation is the chemotherapy worth in advanced head and neck cancer?
    • Kasibhatla M, Kirkpatrick JP, Brizel DM. How much radiation is the chemotherapy worth in advanced head and neck cancer? Int J Radiat Oncol Biol Phys 2007; 68: 1491-5.
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , pp. 1491-1495
    • Kasibhatla, M.1    Kirkpatrick, J.P.2    Brizel, D.M.3
  • 20
    • 0032543663 scopus 로고    scopus 로고
    • Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer
    • Brizel DM, Albers ME, Fisher SR, Scher RL, Richtsmeier WJ, Hars V, et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med 1998; 338: 1798-04.
    • (1998) N Engl J Med , vol.338 , pp. 1798-1704
    • Brizel, D.M.1    Albers, M.E.2    Fisher, S.R.3    Scher, R.L.4    Richtsmeier, W.J.5    Hars, V.6
  • 21
    • 0033572234 scopus 로고    scopus 로고
    • Radiotherapy and concurrent chemotherapy: A strategy that improves locoregional control and survival in oropharyngeal cancer
    • Forastiere AA, Trotti A. Radiotherapy and concurrent chemotherapy: A strategy that improves locoregional control and survival in oropharyngeal cancer. J Natl Cancer Inst 1999; 91: 2065-6.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 2065-2066
    • Forastiere, A.A.1    Trotti, A.2
  • 23
    • 66949128922 scopus 로고    scopus 로고
    • MACH-NC Collaborative Group Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients
    • Pignon JP, le Maître A, Maillard E, Bourhis J. MACH-NC Collaborative Group Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009; 92: 4-14.
    • (2009) Radiother Oncol , vol.92 , pp. 4-14
    • Pignon, J.P.1    le Maître, A.2    Maillard, E.3    Bourhis, J.4
  • 24
    • 9744239081 scopus 로고    scopus 로고
    • Update of MACH-NC (Meta-Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy
    • abstr
    • Bourhis J, Armand C, Pignon JP. Update of MACH-NC (Meta-Analysis of Chemotherapy in Head & Neck Cancer) database focused on concomitant chemoradiotherapy. J Clin Oncol 2004; 22 (Suppl; abstr 5505): 489S.
    • (2004) J Clin Oncol , vol.22 , Issue.5505 SUPPL.
    • Bourhis, J.1    Armand, C.2    Pignon, J.P.3
  • 25
    • 2342517421 scopus 로고    scopus 로고
    • Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck
    • Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 2004; 350: 1937-44.
    • (2004) N Engl J Med , vol.350 , pp. 1937-1944
    • Cooper, J.S.1    Pajak, T.F.2    Forastiere, A.A.3    Jacobs, J.4    Campbell, B.H.5    Saxman, S.B.6
  • 27
    • 25844523780 scopus 로고    scopus 로고
    • Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501)
    • Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al. Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501). Head Neck 2005; 27: 843-50.
    • (2005) Head Neck , vol.27 , pp. 843-850
    • Bernier, J.1    Cooper, J.S.2    Pajak, T.F.3    van Glabbeke, M.4    Bourhis, J.5    Forastiere, A.6
  • 28
    • 33644516280 scopus 로고    scopus 로고
    • A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck
    • Budach W, Hehr T, Budach V, Belka C, Dietz K. A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer 2006; 6: 28.
    • (2006) BMC Cancer , vol.6 , pp. 28
    • Budach, W.1    Hehr, T.2    Budach, V.3    Belka, C.4    Dietz, K.5
  • 29
    • 33645344341 scopus 로고    scopus 로고
    • Efficacy of intensified hyperfractionated and accelerated radiotherapy and concurrent chemotherapy with carboplatin and 5-fluorouracil: Updated results of a randomized multicentrictrial in advanced head-and-neck cancer
    • Semrau R, Mueller RP, Stuetzer H, Staar S, Schroeder U, Guntinas-Lichius O, et al. Efficacy of intensified hyperfractionated and accelerated radiotherapy and concurrent chemotherapy with carboplatin and 5-fluorouracil: Updated results of a randomized multicentrictrial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2006; 64: 1308-16.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 1308-1316
    • Semrau, R.1    Mueller, R.P.2    Stuetzer, H.3    Staar, S.4    Schroeder, U.5    Guntinas-Lichius, O.6
  • 31
    • 0036617960 scopus 로고    scopus 로고
    • The role of docetaxel in the management of squamous cell cancer of the head and neck
    • Glisson BS. The role of docetaxel in the management of squamous cell cancer of the head and neck. Oncology (Williston Park) 2002; 16 (6 Suppl 6): 83-7.
    • (2002) Oncology (Williston Park) , vol.16 , Issue.6 SUPPL. 6 , pp. 83-87
    • Glisson, B.S.1
  • 32
    • 0033934622 scopus 로고    scopus 로고
    • Role of taxoids in head and neck cancer
    • Schrijvers D, Vermorken JB. Role of taxoids in head and neck cancer. Oncologist 2000; 5: 199-208.
    • (2000) Oncologist , vol.5 , pp. 199-208
    • Schrijvers, D.1    Vermorken, J.B.2
  • 33
    • 21344460057 scopus 로고    scopus 로고
    • Alteration of radiotherapy fractionation and concurrent chemotherapy: A new frontier in head and neck oncology?
    • Bernier J. Alteration of radiotherapy fractionation and concurrent chemotherapy: A new frontier in head and neck oncology? Nat Clin Pract Oncol 2005; 2: 305-14.
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 305-314
    • Bernier, J.1
  • 34
    • 0022588917 scopus 로고
    • The impact of conventional morphologic analysis on response rates and survival in patients with advanced head and neck cancers treated initially with cisplatin-containing combination chemotherapy
    • Ensley J, Crissman J, Kish J, Jacobs J, Weaver A, Kinzie J, et al. The impact of conventional morphologic analysis on response rates and survival in patients with advanced head and neck cancers treated initially with cisplatin-containing combination chemotherapy. Cancer 1986; 57: 711-7.
    • (1986) Cancer , vol.57 , pp. 711-717
    • Ensley, J.1    Crissman, J.2    Kish, J.3    Jacobs, J.4    Weaver, A.5    Kinzie, J.6
  • 35
    • 0018772316 scopus 로고
    • Induction chemotherapy in advanced squamous head and neck carcinoma with high-dose cis-platinum and bleomycin infusion
    • Hong WK, Shapshay SM, Bhutani R, Craft ML, Ucmakli A, Yamaguchi KT, et al. Induction chemotherapy in advanced squamous head and neck carcinoma with high-dose cis-platinum and bleomycin infusion. Cancer 1979; 44: 19-25.
    • (1979) Cancer , vol.44 , pp. 19-25
    • Hong, W.K.1    Shapshay, S.M.2    Bhutani, R.3    Craft, M.L.4    Ucmakli, A.5    Yamaguchi, K.T.6
  • 36
    • 0022477649 scopus 로고
    • A pilot study of cisplatin-vinblastine as the initial treatment of advanced head and neck cancer
    • Leitner SP, Bosl GJ, Strong EW, Gerold FP, Spiro RH, Shah JP, et al. A pilot study of cisplatin-vinblastine as the initial treatment of advanced head and neck cancer. Cancer 1986; 58: 1014-7.
    • (1986) Cancer , vol.58 , pp. 1014-1017
    • Leitner, S.P.1    Bosl, G.J.2    Strong, E.W.3    Gerold, F.P.4    Spiro, R.H.5    Shah, J.P.6
  • 37
    • 0021838884 scopus 로고
    • Preoperative intra-arterial infusion chemotherapy for advanced squamous cell carcinoma of the mouth and oropharynx
    • Milazzo J, Mohit-Tabatabai MA, Hill GJ, Raina S, Swaminathan A, Cheung NK, et al. Preoperative intra-arterial infusion chemotherapy for advanced squamous cell carcinoma of the mouth and oropharynx. Cancer 1985; 56: 1014-7.
    • (1985) Cancer , vol.56 , pp. 1014-1017
    • Milazzo, J.1    Mohit-Tabatabai, M.A.2    Hill, G.J.3    Raina, S.4    Swaminathan, A.5    Cheung, N.K.6
  • 38
    • 24944483456 scopus 로고    scopus 로고
    • Induction chemotherapy for head and neck cancer: Will history repeat itself?
    • Argiris A. Induction chemotherapy for head and neck cancer: Will history repeat itself? J Natl Compr Cancer Netw 2005; 3: 393-403.
    • (2005) J Natl Compr Cancer Netw , vol.3 , pp. 393-403
    • Argiris, A.1
  • 39
    • 4444346176 scopus 로고    scopus 로고
    • Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: A 9-year, 337-patient, multiinstitutional experience
    • Brockstein B, Haraf DJ, Rademaker AW, Kies MS, Stenson KM, Rosen F, et al. Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: A 9-year, 337-patient, multiinstitutional experience. Ann Oncol 2004; 15: 1179-86.
    • (2004) Ann Oncol , vol.15 , pp. 1179-1186
    • Brockstein, B.1    Haraf, D.J.2    Rademaker, A.W.3    Kies, M.S.4    Stenson, K.M.5    Rosen, F.6
  • 41
    • 69349089667 scopus 로고    scopus 로고
    • Final results of a randomized phase III trial comparing induction chemotherapy with cisplatin/5-FU or docetaxel/ cisplatin/5-FU follow by chemoradiotherapy (CRT) versus CRT alone as first-line treatment of unresectable locally advanced head and neck cancer (LAHNC)
    • abstr 6009
    • Hitt R, Grau JJ, Lopez-Pousa A, Berrocal A, Garcia GC, Irigoyen A, et al. Final results of a randomized phase III trial comparing induction chemotherapy with cisplatin/5-FU or docetaxel/ cisplatin/5-FU follow by chemoradiotherapy (CRT) versus CRT alone as first-line treatment of unresectable locally advanced head and neck cancer (LAHNC). 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2009; 27(suppl; abstr 6009):15s.
    • (2009) 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol , vol.27 , Issue.SUPPL.
    • Hitt, R.1    Grau, J.J.2    Lopez-Pousa, A.3    Berrocal, A.4    Garcia, G.C.5    Irigoyen, A.6
  • 42
    • 0345714860 scopus 로고    scopus 로고
    • Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer
    • Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 2003; 349: 2091-8.
    • (2003) N Engl J Med , vol.349 , pp. 2091-2098
    • Forastiere, A.A.1    Goepfert, H.2    Maor, M.3    Pajak, T.F.4    Weber, R.5    Morrison, W.6
  • 43
    • 33748163045 scopus 로고    scopus 로고
    • Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer
    • Rosenthal DI, Lewin JS, Eisbruch A. Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol 2006; 24: 2636-43.
    • (2006) J Clin Oncol , vol.24 , pp. 2636-2643
    • Rosenthal, D.I.1    Lewin, J.S.2    Eisbruch, A.3
  • 44
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: The complexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341
    • Hynes, N.E.1    Lane, H.A.2
  • 45
    • 0028339821 scopus 로고
    • The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities
    • Bonner JA, Maihle NJ, Folven BR, Christianson TJ, Spain K. The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities. Int J Radiat Oncol Biol Phys 1994; 29: 243-7.
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 243-247
    • Bonner, J.A.1    Maihle, N.J.2    Folven, B.R.3    Christianson, T.J.4    Spain, K.5
  • 47
    • 84871471276 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study. J Clin Oncol 2006; 24: 724.
    • (2006) J Clin Oncol , vol.24 , pp. 724
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 48
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinumbased therapy
    • Vermorken JB, Trigo J, Hitt R, Koralewski P, Diaz-Rubio E, Rolland F, et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinumbased therapy. J Clin Oncol 2007; 25: 2171-7.
    • (2007) J Clin Oncol , vol.25 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3    Koralewski, P.4    Diaz-Rubio, E.5    Rolland, F.6
  • 50
    • 61849160432 scopus 로고    scopus 로고
    • Cetuximab therapy for patients with advanced squamous cell carcinomas of the head and neck
    • William WN Jr, Kim ES, Herbst RS. Cetuximab therapy for patients with advanced squamous cell carcinomas of the head and neck. Nat Clin Pract Oncol 2009; 6: 132-3.
    • (2009) Nat Clin Pract Oncol , vol.6 , pp. 132-133
    • William Jr., W.N.1    Kim, E.S.2    Herbst, R.S.3
  • 51
    • 0034104525 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily: Role as anticancer agents
    • Noonberg SB, Benz CC. Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily: Role as anticancer agents. Drugs 2000; 59: 753-67.
    • (2000) Drugs , vol.59 , pp. 753-767
    • Noonberg, S.B.1    Benz, C.C.2
  • 53
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM, Recant W, Stenson K, Huo D, et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003; 21: 1980-7.
    • (2003) J Clin Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3    Recant, W.4    Stenson, K.5    Huo, D.6
  • 54
    • 79954468998 scopus 로고    scopus 로고
    • Survival benefit and efficacy of gefitinib in recurrent metastatic head and neck cancer
    • Rao R, Anil K, Bansal L, Dhiman A, Khatri S, Rawat S, et al. Survival benefit and efficacy of gefitinib in recurrent metastatic head and neck cancer. Ind J Med Paed Oncol 2007; 28: 5-10.
    • (2007) Ind J Med Paed Oncol , vol.28 , pp. 5-10
    • Rao, R.1    Anil, K.2    Bansal, L.3    Dhiman, A.4    Khatri, S.5    Rawat, S.6
  • 55
    • 36849051467 scopus 로고    scopus 로고
    • Phase I trial of gefitinib in combination with radiation or chemoradiation for patients with locally advanced squamous cell head and neck cancer
    • Chen C, Kane M, Song J, Campana J, Raben A, Hu K, et al. Phase I trial of gefitinib in combination with radiation or chemoradiation for patients with locally advanced squamous cell head and neck cancer. J Clin Oncol 2007; 25: 4880-6.
    • (2007) J Clin Oncol , vol.25 , pp. 4880-4886
    • Chen, C.1    Kane, M.2    Song, J.3    Campana, J.4    Raben, A.5    Hu, K.6
  • 57
    • 0023279839 scopus 로고
    • Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer
    • Sainsbury JR, Farndon JR, Needham GK, Malcolm AJ, Harris AL. Epidermal-growth-factor receptor status as predictor of early recurrence of and death from breast cancer. Lancet 1987; 1: 1398-402.
    • (1987) Lancet , vol.1 , pp. 1398-1402
    • Sainsbury, J.R.1    Farndon, J.R.2    Needham, G.K.3    Malcolm, A.J.4    Harris, A.L.5
  • 58
    • 48749113487 scopus 로고    scopus 로고
    • Antitumor effect of gefitinib on head and neck squamous cell carcinoma enhanced by trastuzumab
    • Kondo N, Ishiguro Y, Kimura M, Sano D, Fujita K, Sakakibara A, et al. Antitumor effect of gefitinib on head and neck squamous cell carcinoma enhanced by trastuzumab. Oncol Rep 2008; 20: 373-8.
    • (2008) Oncol Rep , vol.20 , pp. 373-378
    • Kondo, N.1    Ishiguro, Y.2    Kimura, M.3    Sano, D.4    Fujita, K.5    Sakakibara, A.6
  • 60
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004; 22: 77-85.
    • (2004) J Clin Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 61
    • 77958472983 scopus 로고    scopus 로고
    • Initial results of a phase I dose-escalation trial of concurrent and maintenance erlotinib and reirradiation for recurrent and new primary head-and-neck cancer
    • Rusthoven KE, Feigenberg SJ, Raben D, Kane M, Song JI, Nicolaou N, et al. Initial results of a phase I dose-escalation trial of concurrent and maintenance erlotinib and reirradiation for recurrent and new primary head-and-neck cancer. Int J Radiat Oncol Biol Phys 2010; 78(4): 1020-5.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , Issue.4 , pp. 1020-1025
    • Rusthoven, K.E.1    Feigenberg, S.J.2    Raben, D.3    Kane, M.4    Song, J.I.5    Nicolaou, N.6
  • 62
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 2006; 33: 369-85.
    • (2006) Semin Oncol , vol.33 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 63
    • 79953801628 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of erlotinib (OSI-774) in combination with docetaxel in squamous cell carcinoma of the head and neck (SSCHN)
    • May 19 [Epub ahead of print]
    • Kraut EH, Rhoades C, Zhang Y, Cheng H, Aimiumu J, Chen P, et al. Phase I and pharmacokinetic study of erlotinib (OSI-774) in combination with docetaxel in squamous cell carcinoma of the head and neck (SSCHN). Cancer Chemother Pharmacol 2010 May 19 [Epub ahead of print].
    • (2010) Cancer Chemother Pharmacol
    • Kraut, E.H.1    Rhoades, C.2    Zhang, Y.3    Cheng, H.4    Aimiumu, J.5    Chen, P.6
  • 64
    • 77949445285 scopus 로고    scopus 로고
    • Antitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma
    • Kondo N, Tsukuda M, Ishiguro Y, Kimura M, Fujita K, Sakakibara A, et al. Antitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma. Oncol Rep 2010; 23: 957-63.
    • (2010) Oncol Rep , vol.23 , pp. 957-963
    • Kondo, N.1    Tsukuda, M.2    Ishiguro, Y.3    Kimura, M.4    Fujita, K.5    Sakakibara, A.6
  • 65
    • 34147146227 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab (T), paclitaxel (P) and cisplatin (C) in metastatic (M) or recurrent (R) head and neck squamous cell carcinoma (HNSCC): Response by tumor EGFR and HER2/neu status
    • 42nd ASCO Annual Meeting. Atlanta, GA, USA (2006), Presented at, abstr 5511
    • Gillison ML, Glisson BS, O'Leary E, Murphy A, Levine A, Kies SM, et al. Phase II trial of trastuzumab (T), paclitaxel (P) and cisplatin (C) in metastatic (M) or recurrent (R) head and neck squamous cell carcinoma (HNSCC): Response by tumor EGFR and HER2/neu status. Presented at: 42nd ASCO Annual Meeting. Atlanta, GA, USA (2006), J Clin Oncol 2006; 25(Suppl: abstr 5511):18S.
    • (2006) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Gillison, M.L.1    Glisson, B.S.2    O'Leary, E.3    Murphy, A.4    Levine, A.5    Kies, S.M.6
  • 67
    • 77949353758 scopus 로고    scopus 로고
    • Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-Nhydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer
    • Cai X, Zhai HX, Wang J, Forrester J, Qu H, Yin L, et al. Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-Nhydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer. J Med Chem 2010; 53: 2000-9.
    • (2010) J Med Chem , vol.53 , pp. 2000-2009
    • Cai, X.1    Zhai, H.X.2    Wang, J.3    Forrester, J.4    Qu, H.5    Yin, L.6
  • 68
    • 77951440064 scopus 로고    scopus 로고
    • Molecular targeted therapies in all histologies of head and neck cancers: An update
    • Razak AR, Siu LL, Le Tourneau C. Molecular targeted therapies in all histologies of head and neck cancers: an update. Curr Opin Oncol 2010; 22: 212-20.
    • (2010) Curr Opin Oncol , vol.22 , pp. 212-220
    • Razak, A.R.1    Siu, L.L.2    Le Tourneau, C.3
  • 69
    • 67449098380 scopus 로고    scopus 로고
    • Angiogenic growth factors in tissue homogenates of HNSCC: Expression pattern, prognostic relevance, and interrelationships
    • Montag M, Dyckhoff G, Lohr J, Helmke BM, Herrmann E, Plinkert PK, et al. Angiogenic growth factors in tissue homogenates of HNSCC: Expression pattern, prognostic relevance, and interrelationships. Cancer Sci 2009; 100: 1210-8.
    • (2009) Cancer Sci , vol.100 , pp. 1210-1218
    • Montag, M.1    Dyckhoff, G.2    Lohr, J.3    Helmke, B.M.4    Herrmann, E.5    Plinkert, P.K.6
  • 70
    • 62349097073 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A phase I/II study
    • Cohen EE, Davis DW, Karrison TG, Seiwert TY, Wong SJ, Nattam S, et al. Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol 2009; 10: 247-57.
    • (2009) Lancet Oncol , vol.10 , pp. 247-257
    • Cohen, E.E.1    Davis, D.W.2    Karrison, T.G.3    Seiwert, T.Y.4    Wong, S.J.5    Nattam, S.6
  • 71
    • 34548504810 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma
    • Elser C, Siu LL, Winquist E, Agulnik M, Pond GR, Chin SF, et al. Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma. J Clin Oncol 2007; 25: 3766-73.
    • (2007) J Clin Oncol , vol.25 , pp. 3766-3773
    • Elser, C.1    Siu, L.L.2    Winquist, E.3    Agulnik, M.4    Pond, G.R.5    Chin, S.F.6
  • 72
    • 73949143686 scopus 로고    scopus 로고
    • Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01
    • Machiels JP, Henry S, Zanetta S, Kaminsky MC, Michoux N, Rommel D, et al. Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01. J Clin Oncol 2010; 28: 21-8.
    • (2010) J Clin Oncol , vol.28 , pp. 21-28
    • Machiels, J.P.1    Henry, S.2    Zanetta, S.3    Kaminsky, M.C.4    Michoux, N.5    Rommel, D.6
  • 73
  • 79
    • 79954546699 scopus 로고    scopus 로고
    • rd Annual American Society of Clinical Oncology Meeting
    • Presented at, abstr
    • rd Annual American Society of Clinical Oncology Meeting, J Clin Oncol 2007; 25(suppl; abstr 6044): 15s.
    • (2007) J Clin Oncol , vol.25 , Issue.6044 SUPPL.
    • Williamson, S.1    Moon, J.2    Huang, C.3
  • 80
    • 67749135818 scopus 로고    scopus 로고
    • A phase II study of lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck
    • Hanrahan EO, Kies MS, Glisson BS, Khuri FR, Feng L, Tran HT, et al. A phase II study of lonafarnib (SCH66336) in patients with chemorefractory, advanced squamous cell carcinoma of the head and neck. Am J Clin Oncol 2009; 32: 274-9.
    • (2009) Am J Clin Oncol , vol.32 , pp. 274-279
    • Hanrahan, E.O.1    Kies, M.S.2    Glisson, B.S.3    Khuri, F.R.4    Feng, L.5    Tran, H.T.6
  • 81
    • 33751184394 scopus 로고    scopus 로고
    • A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer
    • Argiris A, Cohen E, Karrison T, Esparaz B, Mauer A, Ansari R, et al. A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer. Cancer Biol Ther 2006; 5: 766-70.
    • (2006) Cancer Biol Ther , vol.5 , pp. 766-770
    • Argiris, A.1    Cohen, E.2    Karrison, T.3    Esparaz, B.4    Mauer, A.5    Ansari, R.6
  • 82
    • 38149140216 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor vorinostat (zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer
    • Blumenschein GR Jr, Kies MS, Papadimitrakopoulou VA, Lu C, Kumar AJ, Ricker JL, et al. Phase II trial of the histone deacetylase inhibitor vorinostat (zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer. Invest New Drugs 2008; 26: 81-7.
    • (2008) Invest New Drugs , vol.26 , pp. 81-87
    • Blumenschein Jr., G.R.1    Kies, M.S.2    Papadimitrakopoulou, V.A.3    Lu, C.4    Kumar, A.J.5    Ricker, J.L.6
  • 83
    • 77956671026 scopus 로고    scopus 로고
    • Phase II randomized trial of bortezomib (B) plus irinotecan (I) or B with addition of I at progression in recurrent (R) or metastatic (M) squamous cell carcinoma of the head and neck (SCCHN) (E1304): A trial of the Eastern Cooperative Oncology Group
    • abstr 6020
    • Gilbert J, Lee J, Argiris A, Feldman LM, Haigentz B, Burtness, et al. Phase II randomized trial of bortezomib (B) plus irinotecan (I) or B with addition of I at progression in recurrent (R) or metastatic (M) squamous cell carcinoma of the head and neck (SCCHN) (E1304): A trial of the Eastern Cooperative Oncology Group. Presented at 45th Annual American Society of Clinical Oncology meeting, J Clin Oncol 2009; 27 (suppl; abstr 6020): 15s.
    • (2009) Presented at 45th Annual American Society of Clinical Oncology meeting, J Clin Oncol , vol.27 , Issue.SUPPL.
    • Gilbert, J.1    Lee, J.2    Argiris, A.3    Feldman, L.M.4    Haigentz, B.5    Burtness6
  • 85
    • 13444273394 scopus 로고    scopus 로고
    • Cancer gene expression database (CGED): A database for gene expression profiling with accompanying clinical information of human cancer tissues
    • Kato K, Yamashita R, Matoba R, Monden M, Noguchi S, Takagi T, et al. Cancer gene expression database (CGED): A database for gene expression profiling with accompanying clinical information of human cancer tissues. Nucleic Acids Res 2005; 33: 533-6.
    • (2005) Nucleic Acids Res , vol.33 , pp. 533-536
    • Kato, K.1    Yamashita, R.2    Matoba, R.3    Monden, M.4    Noguchi, S.5    Takagi, T.6
  • 86
    • 0036173666 scopus 로고    scopus 로고
    • Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation
    • Shono T, Tofilon PJ, Schaefer TS, Parikh D, Liu TJ, Lang FF. Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer Res 2002; 62: 1069-76.
    • (2002) Cancer Res , vol.62 , pp. 1069-1076
    • Shono, T.1    Tofilon, P.J.2    Schaefer, T.S.3    Parikh, D.4    Liu, T.J.5    Lang, F.F.6
  • 87
    • 70350073706 scopus 로고    scopus 로고
    • Cancer gene therapy with oncolytic adenoviruses
    • Guse K, Hemminki A. Cancer gene therapy with oncolytic adenoviruses. J BUON 2009; 14 (Suppl 1): S7-15.
    • (2009) J BUON , vol.14 , Issue.SUPPL. 1
    • Guse, K.1    Hemminki, A.2
  • 88
    • 0033789630 scopus 로고    scopus 로고
    • Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines
    • Parker LP, Wolf JK, Price JE. Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines. Ann Clin Lab Sci 2000; 30: 395-405.
    • (2000) Ann Clin Lab Sci , vol.30 , pp. 395-405
    • Parker, L.P.1    Wolf, J.K.2    Price, J.E.3
  • 89
    • 0031750168 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
    • Clayman GL, El-Naggar AK, Lippman SM, Henderson YC, Frederick M, Merritt JA, et al. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 1998; 16: 2221-32.
    • (1998) J Clin Oncol , vol.16 , pp. 2221-2232
    • Clayman, G.L.1    El-Naggar, A.K.2    Lippman, S.M.3    Henderson, Y.C.4    Frederick, M.5    Merritt, J.A.6
  • 90
    • 73349137611 scopus 로고    scopus 로고
    • Biomarkers predict p53 gene therapy efficacy in recurrent, squamous cell carcinoma of the head and neck
    • Nemunaitis J, Clayman G, Agarwala SS, Hrushesky W, Wells JR, Moore C, et al. Biomarkers predict p53 gene therapy efficacy in recurrent, squamous cell carcinoma of the head and neck. Clin Cancer Res 2009; 15: 7719-25.
    • (2009) Clin Cancer Res , vol.15 , pp. 7719-7725
    • Nemunaitis, J.1    Clayman, G.2    Agarwala, S.S.3    Hrushesky, W.4    Wells, J.R.5    Moore, C.6
  • 91
    • 70349348934 scopus 로고    scopus 로고
    • A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMVp53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: Report of the Southwest Oncology Group
    • Yoo GH, Moon J, Leblanc M, Lonardo F, Urba S, Kim H, et al. A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMVp53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: Report of the Southwest Oncology Group. Arch Otolaryngol Head Neck Surg 2009;13: 869-74.
    • (2009) Arch Otolaryngol Head Neck Surg , vol.13 , pp. 869-874
    • Yoo, G.H.1    Moon, J.2    Leblanc, M.3    Lonardo, F.4    Urba, S.5    Kim, H.6
  • 92
    • 69249208557 scopus 로고    scopus 로고
    • Immunotherapy of head and neck cancer: Current and future considerations
    • Rapidis AD, Wolf GT. Immunotherapy of head and neck cancer: Current and future considerations. J Oncol 2009; 2009: 346-345.
    • (2009) J Oncol , vol.2009 , pp. 346-345
    • Rapidis, A.D.1    Wolf, G.T.2
  • 93
    • 67449143515 scopus 로고    scopus 로고
    • Immune response to vaccination with DNA-Hsp65 in a phase I clinical trial with head and neck cancer patients
    • Victora GD, Socorro-Silva A, Volsi EC, Abdallah K, Lima FD, Smith RB, et al. Immune response to vaccination with DNA-Hsp65 in a phase I clinical trial with head and neck cancer patients. Cancer Gene Ther 2009;16: 598-608.
    • (2009) Cancer Gene Ther , vol.16 , pp. 598-608
    • Victora, G.D.1    Socorro-Silva, A.2    Volsi, E.C.3    Abdallah, K.4    Lima, F.D.5    Smith, R.B.6
  • 95
    • 77349083504 scopus 로고    scopus 로고
    • Optimising the therapeutic ratio in head and neck cancer
    • Corry J, Peters LJ, Rischin D. Optimising the therapeutic ratio in head and neck cancer. Lancet Oncol 2010; 11: 287-91.
    • (2010) Lancet Oncol , vol.11 , pp. 287-291
    • Corry, J.1    Peters, L.J.2    Rischin, D.3
  • 96
    • 36348941014 scopus 로고    scopus 로고
    • Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima(R) in combination with radiotherapy in EGFRpositive and EGFR-null human head and neck tumor xenografts
    • Gustafson DL, Frederick B, Merz AL, Raben D. Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima(R) in combination with radiotherapy in EGFRpositive and EGFR-null human head and neck tumor xenografts. Cancer Chemother Pharmacol 2008; 61: 179-88.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 179-188
    • Gustafson, D.L.1    Frederick, B.2    Merz, A.L.3    Raben, D.4
  • 98
    • 64249088367 scopus 로고    scopus 로고
    • Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation
    • van den Broek GB, Wildeman M, Rasch CR, Armstrong N, Schuuring E, Begg AC, et al. Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation. Int J Cancer 2009; 124: 2643-50.
    • (2009) Int J Cancer , vol.124 , pp. 2643-2650
    • van den Broek, G.B.1    Wildeman, M.2    Rasch, C.R.3    Armstrong, N.4    Schuuring, E.5    Begg, A.C.6
  • 101
    • 51449116659 scopus 로고    scopus 로고
    • Feasibility of using bevacizumab with radiation therapy and temozolomide in newly diagnosed high-grade glioma
    • Narayana A, Golfinos JG, Fischer I, Raza S, Kelly P, Parker E, et al. Feasibility of using bevacizumab with radiation therapy and temozolomide in newly diagnosed high-grade glioma. Int J Radiat Oncol Biol Phys 2008; 72: 383-9.
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , pp. 383-389
    • Narayana, A.1    Golfinos, J.G.2    Fischer, I.3    Raza, S.4    Kelly, P.5    Parker, E.6


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