Expression and unique functions of four nuclear factor of activated T cells isoforms in non-small cell lung cancer

Chinese Journal of Cancer

Volumn 30, Issue 1, 2011, Pages 62-68

  Chen, Zhao Li ^a   Zhao, Shou Hua ^b   Wang, Zhen ^a   Qiu, Bin ^a   Li, Bao Zhong ^a   Zhou, Fang ^a   Tan, Xiao Gang ^a   He, Jie ^a  

^a CANCER HOSPITAL   (China)

^b Tengzhou Center People Hospital   (China)

Author keywords

Calcineurin; Lung neoplasms; NFATC transcription factors

Indexed keywords

CALCINEURIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; TRANSCRIPTION FACTOR NFAT2; TRANSCRIPTION FACTOR NFAT3; TRANSCRIPTION FACTOR NFAT4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEX DIFFERENCE; TISSUE MICROARRAY; TUMOR DIFFERENTIATION;

EID: 79954465036     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.010.10156     Document Type: Article

References (19)

1. Mancini M, Toker A. NFAT proteins: emerging roles in cancer progression [J]. Nat Rev Cancer, 2009,9(11):810-820.
2. Duque J, Fresno M, Iniguez MA. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2 [J]. J Biol Chem, 2005,280(10):8686-8693.
3. Corral RS, Iniguez MA, Duque J, et al. Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells [J]. Oncogene, 2007,26(7):958-969.
4. Jauliac S, Lopez-Rodriguez C, Shaw LM, et al. The role of NFAT transcription factors in integrin-mediated carcinoma invasion [J]. Nat Cell Biol, 2002,4(7):540-544.
5. Yiu GK, Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2 [J]. J Biol Chem, 2006,281(18):12210-12217.
6. Yoeli-Lerner M, Yiu GK, Rabinovitz I, et al. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT [J]. Mol Cell, 2005,20(4):539-550.
7. 27calcineurin signaling pathway [J]. Embo J, 2006,25(15): 3714-3724.
8. Koenig A, Linhart T, Schlengemann K, et al. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells [J]. Gastroenterology, 2009, 138(3):1189-1199.
9. Sales KJ, Maldonado-Perez D, Grant V, et al. Prostaglandin F (2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway [J]. Biochim Biophys Ada, 2009,1793(12):1917-1928.
10. Flockhart RJ, Armstrong JL, Reynolds NJ, et al. NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma [J]. Br J Cancer, 2009,101(8):1448-1455.
11. Nguyen AH, Beland M, Gaitan Y, et al. Calcineurin a-binding protein, a novel modulator of the calcineurin-nuclear factor of activated T-cell signaling pathway, is overexpressed in wilms' tumors and promotes cell migration [J]. Mol Cancer Res, 2009, 7(6): 821-831.
12. Dave V, Childs T, Xu Y, et al. Calcineurin/Nfat signaling is required for perinatal lung maturation and function [J]. J Clin Invest, 2006,116(10):2597-2609.
13. Dave V, Childs T, Whitsett JA. Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (SFTPD) via direct interaction with thyroid transcription factor-1 in lung epithelial cells [J]. J Biol Chem, 2004,279(33):34578-34588.
14. Ding J, Li J, Xue C, et al. Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells [J]. J Biol Chem, 2006,281 (34): 24405-24413.
15. Zhang K, Li N, Chen Z, et al. High expression of nuclear factor of activated T cells in Chinese primary non-small cell lung cancer tissues [J]. Int J Biol Markers, 2007,22(3):221-225.
16. Masuda ES, Imamura R, Amasaki Y, et al. Signalling into the T-cell nucleus: NFAT regulation [J]. Cell Signal, 1998,10(9):599-611.
17. Horsley V, Pavlath GK. NFAT: ubiquitous regulator of cell differentiation and adaptation [J]. J Cell Biol, 2002,156(5):771-774.
18. Amasaki Y, Adachi S, Ishida Y, et al. A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells [J]. J Biol Chem, 2002, 277(28):25640-25648.
19. Robbs BK, Cruz AL, Werneck MB, et al. Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors [J]. Mol Cell Biol, 2008,28(23):7168-7181.