The extracellular matrix protein CCN1 dictates TNFα and fasL cytotoxicity in vivo

Advances in Experimental Medicine and Biology

Volumn 691, Issue , 2011, Pages 595-603

  Chen, Chih Chiun ^a   Juric, Vladislava ^b   Lau, Lester F ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; CTGF; CYR61; FasL; Inflammation; NOV; TNF; TRAIL

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CYSTEINE RICH PROTEIN 61; FAS LIGAND; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; PROTEOHEPARAN SULFATE; REACTIVE OXYGEN METABOLITE; SCLEROPROTEIN; SOMATOMEDIN BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VON WILLEBRAND FACTOR;

AMINO TERMINAL SEQUENCE; APOPTOSIS; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; CYTOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MICROENVIRONMENT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ANIMAL; ARTICLE; BIOLOGICAL MODEL; EXTRACELLULAR MATRIX; HUMAN; METABOLISM; MOUSE;

ANIMALS; APOPTOSIS; CYSTEINE-RICH PROTEIN 61; EXTRACELLULAR MATRIX; FAS LIGAND PROTEIN; HUMANS; MICE; MODELS, BIOLOGICAL; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79954451221     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6612-4_63     Document Type: Conference Paper

References (52)

1. Aggarwal BB (2003) Signalling pathways of the TNF superfamily: A double-edged sword. Nat Rev Immunol 3:745-756
2. Bertazza L, Mocellin S (2008) Tumor necrosis factor (TNF) biology and cell death. Front Biosci 13:2736-2743
3. Balkwill F (2009) Tumour necrosis factor and cancer. Nat Rev Cancer 9:361-371
4. Varfolomeev EE, Ashkenazi A (2004) Tumor necrosis factor: An apoptosis JuNKie? Cell 116:491-497
5. Muppidi JR, Tschopp J, Siegel RM (2004) Life and death decisions: Secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 21:461-465
6. Chen C-C, Lau LF (2009) Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41:771-783
7. Holbourn KP, Acharya KR, Perbal B (2008) The CCN family of proteins: Structure-function relationships. Trends Biochem Sci 33:461-473
8. Leask A, Abraham DJ (2006) All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci 119:4803-4810
9. Bornstein P, Sage EH (2002) Matricellular proteins: Extracellular modulators of cell function. Curr Opin Cell Biol 14:608-616
10. Lau LF, Lam SC (1999) The CCN family of angiogenic regulators: The integrin connection. Exp Cell Res 248:44-57
11. Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF (2002) CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol 22:8709-8720
12. Mo F-E, Lau LF (2006) The matricellular protein CCN1 is essential for cardiac development. Circ Res 99:961-969
13. Ivkovic S, Popoff SN, Safadi FF, Zhao M, Stephenson RC, Yoon BS, Daluiski A, Segarini P, Lyons KM (2003) Connective tissue growth factor is an essential regulator of skeletal development. Development 130:2791
14. Canalis E, Smerdel-Ramoya A, Durant D, Economides AN, Beamer WG, Zanotti S (2010) Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but Nov is dispensable for skeletal homeostasis. Endocrinology 151: 221-233
15. Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3: 221-227
16. Chen C-C, Young JL, Monzon RI, Chen N, Todorovic V, Lau LF (2007) Cytotoxicity of TNFa is regulated by integrin-mediated matrix signaling. EMBO J 26:1257-1267
17. Juric V, Chen CC, Lau LF (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol 29:3266-3279
18. Franzen CA, Chen CC, Todorovic V, Juric V, Monzon RI, Lau LF (2009) The matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Mol Cancer Res 7:1045-1055
19. Battegay EJ, Raines EW, Colbert T, Ross R (1995) TNF-alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression. J Immunol 154:6040-6047
20. Chen N, Chen CC, Lau LF (2000) Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin a6b1 and cell surface heparan sulfate proteoglycans. J Biol Chem 275: 24953-24961
21. Leu S-J, Chen N, Chen C-C, Todorovic V, Bai T, Juric V, Liu Y, Yan G, Lam SCT, Lau LF (2004) Targeted mutagenesis of the matricellular protein CCN1 (CYR61): Selective inactivation of integrin a6b1-heparan sulfate proteoglycan coreceptor-mediated cellular activities. J Biol Chem 279:44177-44187
22. Trautwein C, Rakemann T, Brenner DA, Streetz K, Licato L, Manns MP, Tiegs G (1998) Concanavalin A-induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology 114:1035-1045
23. Wolf D, Hallmann R, Sass G, Sixt M, Kusters S, Fregien B, Trautwein C, Tiegs G (2001) TNF-alpha-induced expression of adhesion molecules in the liver is under the control of TNFR1-relevance for concanavalin A-induced hepatitis. J Immunol 166:1300-1307
24. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364:806-809
25. Zhou Z, Sun X, Kang YJ (2001) Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 159:329-338
26. Kusters S, Gantner F, Kunstle G, Tiegs G (1996) Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111: 462-471
27. Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J (2001) NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 21:5299-5305
28. Thome M, Tschopp J (2001) Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol 1:50-58
29. Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, KarinM(2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124:601-613
30. Wang Z, Cao N, Nantajit D, Fan M, Liu Y, Li JJ (2008) Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation. J Biol Chem 283:21011-21023
31. Meng TC, Fukada T, Tonks NK (2002) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9:387-399
32. Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E, Cong R, Beaumont C et al (2004) Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 119: 529-542
33. Rui T, Kvietys PR (2005) NFkappaB and AP-1 differentially contribute to the induction of Mn-SOD and eNOS during the development of oxidant tolerance. FASEB J 19:1908-1910
34. Chen C-C, Chen N, Lau LF (2001) The angiogenic factors Cyr61 and CTGF induce adhesive signaling in primary human skin fibroblasts. J Biol Chem 276:10443-10452
35. Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, Symons M, Borrello S, Galeotti T, Ramponi G (2003) Reactive oxygen species as essentialmediators of cell adhesion: The oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol 161:933-944
36. Werner E, Werb Z (2002) Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol 158:357-368
37. Kim YS, Morgan MJ, Choksi S, Liu ZG (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 26:675-687
38. Won JS, Singh I (2006) Sphingolipid signaling and redox regulation. Free Radic Biol Med 40:1875-1888
39. Leist M, Gantner F, Jilg S, Wendel A (1995) Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J Immunol 154:1307-1316
40. Czaja MJ, Xu J, Alt E (1995) Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology 108:1849-1854
41. Iimuro Y, Gallucci RM, LusterMI, Kono H, Thurman RG (1997) Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26:1530-1537
42. Tsuji H, Harada A, Mukaida N, Nakanuma Y, Bluethmann H, Kaneko S, Yamakawa K, Nakamura SI, Kobayashi KI, Matsushima K (1997) Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis. Infect Immun 65:1892-1898
43. Sudo K, Yamada Y, Moriwaki H, Saito K, Seishima M (2005) Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice. Cytokine 29:236-244
44. Shibata H, Yoshioka Y, Ohkawa A, Abe Y, Nomura T, Mukai Y, Nakagawa S, Taniai M, Ohta T, Mayumi T et al (2008) The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models. Cytokine 44:229-233
45. Ronco MT, Frances DE, Ingaramo PI, Quiroga AD, Alvarez ML, Pisani GB, Revelli SS, Carnovale CE (2010) Tumor necrosis factor alpha induced by Trypanosoma cruzi infection mediates inflammation and cell death in the liver of infected mice. Cytokine 49:64-72
46. Sugano M, Hata T, Tsuchida K, Suematsu N, Oyama J, Satoh S, Makino N (2004) Local delivery of soluble TNF-alpha receptor 1 gene reduces infarct size following ischemia/reperfusion injury in rats. Mol Cell Biochem 266:127-132
47. Lee P, Sata M, Lefer DJ, Factor SM, Walsh K, Kitsis RN (2003) Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo. Am J Physiol Heart Circ Physiol 284:H456-H463
48. Li Y, Takemura G, Kosai K, Takahashi T, Okada H, Miyata S, Yuge K, Nagano S, Esaki M, Khai NC et al (2004) Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure. Circ Res 95:627-636
49. Hilfiker-Kleiner D, Kaminski K, Kaminska A, Fuchs M, Klein G, Podewski E, Grote K, Kiian I, Wollert KC, Hilfiker A et al (2004) Regulation of proangiogenic factor CCN1 in cardiac muscle: Impact of ischemia, pressure overload, and neurohumoral activation. Circulation 109:2227-2233
50. Chuva de Sousa Lopes SM, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P et al (2004) Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Dev Dyn 231:542-550
51. Chen N, Leu S-J, Todorovic V, Lam SCT, Lau LF (2004) Identification of a novel integrin avb3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. J Biol Chem 279:44166-44176
52. Leu S-J, Liu Y, Chen N, Chen CC, Lam SC, Lau LF (2003) Identification of a novel integrin a6b1 binding site in the angiogenic inducer CCN1 (CYR61). J Biol Chem 278:33801-33808