Effects of intracoronary injection of autologous bone marrow-derived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infarction

Clinical Research in Cardiology

Volumn 100, Issue 4, 2011, Pages 317-325

  Miettinen, Johanna A ^a   Ylitalo, Kari ^a   Hedberg, Pirjo ^a   Kervinen, Kari ^a   Niemelä, Matti ^a   Säily, Marjaana ^a   Koistinen, Pirjo ^a   Savolainen, Eeva Riitta ^a   Ukkonen, Heikki ^b   Pietilä, Mikko ^b   Airaksinen, K E Juhani ^b   Knuuti, Juhani ^b   Vuolteenaho, Olli ^a   Mäkikallio, Timo H ^a   Huikuri, Heikki V ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Bone marrow stem cells; Inflammation; Myocardial infarction; Natriuretic peptides

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; NATRIURETIC FACTOR; TUMOR NECROSIS FACTOR ALPHA;

AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; BLOOD CLOT LYSIS; BLOOD SAMPLING; BONE MARROW CELL; CARDIAC PATIENT; CHEMICAL ANALYSIS; DOUBLE BLIND PROCEDURE; HUMAN; MAJOR CLINICAL STUDY; PERCUTANEOUS CORONARY INTERVENTION; PLACEBO EFFECT; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

AGED; BIOLOGICAL MARKERS; BONE MARROW TRANSPLANTATION; C-REACTIVE PROTEIN; CORONARY VESSELS; DOUBLE-BLIND METHOD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INJECTIONS, INTRA-ARTERIAL; INTERLEUKIN-6; MIDDLE AGED; MYOCARDIAL INFARCTION; NATRIURETIC PEPTIDES; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79954436921     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-010-0246-3     Document Type: Article

References (46)

1. BE Strauer M Brehm T Zeus M Köstering A Hernandez RV Sorg G Kögler P Wernet 2002 Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans Circulation 106 1913 1918 12370212 10.1161/01.CIR.0000034046.87607.1C (Pubitemid 35176294)
2. V Schächinger B Assmus MB Britten J Honold R Lehmann C Teupe ND Abolmaali TJ Vogl WK Hofmann H Martin S Dimmeler AM Zeiher 2004 Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial J Am Coll Cardiol 44 1690 1699 15489105 10.1016/j.jacc.2004.08.014 (Pubitemid 39369805)
3. KC Wollert GP Meyer J Lotz S Ringes-Lichtenberg P Lippolt C Breidenbach S Fichtner T Korte B Hornig D Messinger L Arseniev B Hertenstein A Ganser H Drexler 2004 Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial Lancet 364 141 148 15246726 10.1016/S0140-6736(04)16626-9 (Pubitemid 38891685)
4. J Bartunek M Vanderheyden B Vandekerckhove S Mansour B De Bruyne P De Bondt I Van Haute N Lootens G Heyndrickx W Wijns 2005 Intracoronary injection of CD 133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety Circulation 112 1178 1183
5. J Ge Y Li J Qian J Shi Q Wang Y Niu B Fan X Liu S Zhang A Sun Y Zou 2006 Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI) Heart 92 1764 1767 16775089 10.1136/hrt.2005.085431 1:STN:280:DC%2BD28nmvFSqtg%3D%3D (Pubitemid 44851319)
6. Meluzín J, Mayer J, Groch L, Janousek S, Hornácek I, Hlinomaz O, Kala P, Panovský R, Prásek J, Kamínek M, Stanícek J, Klabusay M, Korístek Z, Navrátil M, Dusek L, Vinklárková J (2006) Autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction: the effect of the dose of transplanted cells on myocardial function. Am Heart J 152:975.e9-975.e15
7. V Schächinger S Erbs A Elsässer W Haberbosch R Hambrecht H Hölschermann J Yu R Corti DG Mathey CW Hamm T Süselbeck B Assmus T Tonn S Dimmeler AM Zeiher REPAIR-AMI investigators 2006 Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction N Engl J Med 355 1210 1221 16990384 10.1056/NEJMoa060186 (Pubitemid 44427445)
8. HV Huikuri K Kervinen M Niemelä K Ylitalo M Säily P Koistinen ER Savolainen H Ukkonen M Pietilä JK Airaksinen J Knuuti TH Mäkikallio FINCELL investigators 2008 Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction Eur Heart J 29 2723 2732 18845667 10.1093/eurheartj/ehn436
9. TG Kwon JH Bae MH Jeong YJ Kim SH Hur IW Seong MC Cho KB Seung YS Jang SJ Park Korea Acute Myocardial Infarction Registry Investigators 2009 N-terminal pro-B-type natriuretic peptide is associated with adverse short-term clinical outcomes in patients with acute ST-elevation myocardial infarction underwent primary percutaneous coronary intervention Int J Cardiol 133 173 178 18281115 10.1016/j.ijcard.2007.12.022
10. S Valente C Lazzeri M Chiostri C Giglioli A Sori S Tigli GF Gensini 2009 NT-proBNP on admission for early risk stratification in STEMI patients submitted to PCI. Relation with extension of STEMI and inflammatory markers Int J Cardiol 132 84 89 18207587 10.1016/j.ijcard.2007.10.045
11. JE Otterstad MG St John Sutton GS Froeland I Holme T Skjaerpe C Hall 2002 Prognostic value of two-dimensional echocardiography and N-terminal proatrial natriuretic peptide following an acute myocardial infarction. Assessment of baseline values (2-7 days) and changes at 3 months in patients with a preserved systolic function Eur Heart J 23 1011 1020 12093053 10.1053/euhj.2001.2969 1:STN:280:DC%2BD38vhtlymtA%3D%3D (Pubitemid 35178124)
12. R Berger M Huelsman K Strecker A Bojic P Moser B Stanek R Pacher 2002 B-type natriuretic peptide predicts sudden death in patients with chronic heart failure Circulation 105 2392 2397 12021226 10.1161/01.CIR.0000016642.15031.34 (Pubitemid 34556391)
13. T Simon R Becker F Voss O Bikou M Hauck M Licka HA Katus A Bauer 2008 Elevated B-type natriuretic peptide levels in patients with nonischemic cardiomyopathy predict occurrence of arrhythmic events Clin Res Cardiol 97 306 309 18193374 10.1007/s00392-007-0629-2 1:CAS:528:DC%2BD1cXmvVCltb0%3D (Pubitemid 351725056)
14. HJ Hwang JW Son BH Nam B Joung B Lee JB Kim MH Lee Y Jang N Chung WH Shim SY Cho SS Kim 2009 Incremental predictive value of pre-procedural N-terminal pro-B-type natriuretic peptide for short-term recurrence in atrial fibrillation ablation Clin Res Cardiol 98 213 218 19229464 10.1007/s00392-009-0744-3 1:CAS:528:DC%2BD1MXjslWrtrk%3D
15. P Järemo O Nilsson 2008 Interleukin-6 and neutrophils are associated with long-term survival after acute myocardial infarction Eur J Intern Med 19 330 333 18549934 10.1016/j.ejim.2007.06.017
16. M Debrunner E Schuiki E Minder E Straumann B Naegeli R Mury O Bertel J Frielingsdorf 2008 Proinflammatory cytokines in acute myocardial infarction with and without cardiogenic shock Clin Res Cardiol 97 298 305 18491171 10.1007/s00392-007-0626-5 1:CAS:528:DC%2BD1cXmvVCltLc%3D (Pubitemid 351725055)
17. KK Ma T Ogawa AJ de Bold 2004 Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by proinflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase J Mol Cell Cardiol 36 505 513 15081310 10.1016/j.yjmcc.2004.01.001 1:CAS:528:DC%2BD2cXjtVegurY%3D (Pubitemid 38469941)
18. T Tanaka T Kanda T Takahashi S Saegusa J Moriya M Kurabayashi 2004 Interleukin-6-induced reciprocal expression of SERCA and natriuretic peptides mRNA in cultured rat ventricular myocytes J Int Med Res 32 57 61 14997707 1:CAS:528:DC%2BD2cXhs1Gmu7g%3D (Pubitemid 38159231)
19. J Jensen LP Ma ML Fu D Svaninger PA Lundberg O Hammarsten 2010 Inflammation increases NT-proBNP and the NT-proBNP/BNP ratio Clin Res Cardiol 99 445 452 20229122 10.1007/s00392-010-0140-z 1:CAS:528:DC%2BC3cXosFGjsbY%3D
20. M Ala-Kopsala J Magga K Peuhkurinen J Leipälä H Ruskoaho J Leppäluoto O Vuolteenaho 2004 Molecular heterogenity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides Clin Chem 50 1576 1588 15265819 10.1373/clinchem.2004.032490 1:CAS:528:DC%2BD2cXnsVaktbc%3D (Pubitemid 39121226)
21. M Ala-Kopsala H Ruskoaho J Leppäluoto L Seres R Skoumal M Toth F Horkay O Vuolteenaho 2005 A single assay for cardiac amino-terminal A- and B-type natriuretic peptides Clin Chem 51 708 718 15718490 10.1373/clinchem.2004. 039891 1:CAS:528:DC%2BD2MXivFCqtL8%3D (Pubitemid 40463922)
22. H Romppanen M Marttila J Magga O Vuolteenaho P Kinnunen I Szokodi H Ruskoaho 1997 Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: blunted effect in experimental hypertension Endocrinology 138 2636 2639 9165059 10.1210/en.138.6.2632 1:CAS:528: DyaK2sXjsVeku7Y%3D (Pubitemid 27215272)
23. KH Miettinen J Magga O Vuolteenaho EJ Vanninen KR Punnonen K Ylitalo P Tuomainen KJ Peuhkurinen 2007 Utility of plasma apelin and other indices of cardiac dysfunction in the clinical assessment of patients with dilated cardiomyopathy Regul Pept 140 178 184 17223209 10.1016/j.regpep.2006.12.004 1:CAS:528:DC%2BD2sXjsVensr0%3D (Pubitemid 46418914)
24. P Hedberg K Ylitalo M Puukka 2004 Highly sensitive determination of C-reactive protein on the Innotrac Aio! immunoanalyzer Scand J Clin Lab Invest 64 677 685 15513325 10.1080/00365510410002931 1:CAS:528:DC%2BD2cXotlOjtbw%3D (Pubitemid 39425307)
25. S Yli-Mäyry HV Huikuri 1993 Clinical and angiographic prediction of myocardial infarction and recurrence of severe angina during a five-year follow-up after coronary artery bypass grafting Am J Cardiol 72 1371 1375 8256729 10.1016/0002-9149(93)90182-C (Pubitemid 24005664)
26. B Assmus U Fischer-Rasokat J Honold FH Seeger S Fichtlscherer T Tonn E Seifried V Schächinger S Dimmeler AM Zeiher TOPCARE-CHD Registry 2007 Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD registry Circ Res 100 1234 1241 17379833 10.1161/01.RES.0000264508.47717.6b 1:CAS:528:DC%2BD2sXktlOhs7Y%3D (Pubitemid 46684137)
27. AM Richards MG Nicholls TG Yandle C Frampton EA Espiner JG Turner RC Buttimore JG Lainchbury JM Elliott H Ikram IG Crozier DW Smyth 1998 Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction Circulation 97 1921 1929 9609085 1:STN:280:DyaK1c3ntVanug%3D%3D
28. T Tsutamoto A Wada K Maeda T Hisanaga Y Maeda D Fukai M Ohnishi Y Sugimoto M Kinoshita 1997 Attenuation of compensation of endogenous cardiac natriuretic peptide system in chronic heart failure: prognostic role of plasma brain natriuretic peptide concentration in patients with chronic symptomatic left ventricular dysfunction Circulation 96 509 516 9244219 1:STN:280: DyaK2szos1eksg%3D%3D (Pubitemid 27329427)
29. F Hartmann M Packer AJ Coats MB Fowler H Krum P Mohacsi JL Rouleau M Tendera A Castaigne SD Anker I Amann-Zalan S Hoersch HA Katus 2004 Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the carvedilol prospective randomized cumulative survival (COPERNICUS) trial Circulation 110 1780 1786 15381643 10.1161/01.CIR.0000143059.68996.A7 1:CAS:528:DC%2BD2cXnslemsL8%3D (Pubitemid 39302655)
30. M Nian P Lee N Khaper P Liu 2004 Inflammatory cytokines and postmyocardial infarction remodeling Circ Res 94 1543 1553 15217919 10.1161/01.RES.0000130526.20854.fa 1:CAS:528:DC%2BD2cXlvVSgtLo%3D (Pubitemid 38856961)
31. M Brehm P Ebner F Picard R Urbien G Turan BE Strauer 2009 Enhanced mobilization of CD34(+) progenitor cells expressing cell adhesion molecules in patients with STEMI Clin Res Cardiol 98 477 486 19479183 10.1007/s00392-009- 0021-5 1:CAS:528:DC%2BD1MXptFGkur8%3D
32. J Charpentier CE Luyt Y Fulla C Vinsonneau A Cariou S Grabar JF Dhainaut JP Mira JD Chiche 2004 Brain natriuretic peptide: a marker of myocardial dysfunction and prognosis during severe sepsis Crit Care Med 32 660 665 15090944 10.1097/01.CCM.0000114827.93410.D8 1:CAS:528:DC%2BD2cXjtlKhtbo%3D (Pubitemid 38340060)
33. M Heil T Ziegelhoeffer B Mees W Schaper 2004 A different outlook on the role of bone marrow stem cells in vascular growth: bone marrow delivers software not hardware Circ Res 94 573 574 15031269 10.1161/01.RES.0000124603.46777.EB 1:CAS:528:DC%2BD2cXisl2jsrs%3D (Pubitemid 38387738)
34. T Ziegelhoeffer B Fernandez S Kostin M Heil R Voswinckel A Helisch W Schaper 2004 Bone marrow derived cells do not incorporate into the adult growing vasculature Circ Res 94 230 238 14656934 10.1161/01.RES.0000110419.50982.1C 1:CAS:528:DC%2BD2cXntlCjug%3D%3D (Pubitemid 38197456)
35. R Uemura M Xu N Ahmad M Ashraf 2006 Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling Circ Res 98 1414 1421 16690882 10.1161/01.RES.0000225952.61196.39 1:CAS:528: DC%2BD28XltFWqtro%3D (Pubitemid 43948066)
36. Solheim S, Seljeflot I, Lunde K, Aukrust P, Yndestad A, Grøgaard HK, Aakhus S, Forfang K, Arnesen H (2008) Inflammatory responses after intracoronary injection of autologous mononuclear bone marrow cells in patients with acute myocardial infarction. Am Heart J 155:55.e1-55.e9
37. G Pannitteri B Marino PP Campa R Martucci U Testa C Peschle 1997 Interleukins 6 and 8 as mediators of acute phase response in acute myocardial infarction Am J Cardiol 80 622 625 9294994 10.1016/S0002-9149(97)00434-7 1:STN:280:DyaK2svjvFCgug%3D%3D (Pubitemid 27386150)
38. R Pudil V Pidrman J Krejsek J Gregor M Tichý C Andrýs M Drahosová 1999 Cytokines and adhesion molecules in the course of acute myocardial infarction Clin Chim Acta 280 127 134 10090530 10.1016/S0009-8981(98) 00179-X 1:CAS:528:DyaK1MXnslyksw%3D%3D (Pubitemid 29094588)
39. M Puhakka J Magga S Hietakorpi I Penttilä P Uusimaa J Risteli K Peuhkurinen 2003 Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation J Card Fail 9 325 332 13680554 10.1054/jcaf.2003.38 1:CAS:528:DC%2BD3sXns1eisLo%3D (Pubitemid 37048026)
40. AS Gabriel A Martinsson B Wretlind S Ahnve 2004 IL-6 levels in acute and post myocardial infarction: their relation to CRP levels, infarction size, left ventricular systolic function, and heart failure Eur J Intern Med 15 523 528 15668089 10.1016/j.ejim.2004.07.013 1:CAS:528:DC%2BD2MXmvFChtQ%3D%3D (Pubitemid 40164483)
41. A Ziakas S Gavrilidis G Giannoglou E Souliou K Gemitzis D Kalampalika MA Vayona I Pidonia G Parharidis G Louridas 2006 In-hospital and long-term prognostic value of fibrinogen, CRP, and IL-6 levels in patients with acute myocardial infarction treated with thrombolysis Angiology 57 283 293 16703188 10.1177/000331970605700304 1:CAS:528:DC%2BD2sXkt1Wjs7w%3D (Pubitemid 44438548)
42. A Aggarwal DJ Schneider EF Terrien KE Gilbert HL Dauerman 2003 Increase in interleukin-6 in the first hour after coronary stenting: an early marker of the inflammatory response J Thromb Thrombolysis 15 25 31 14574073 10.1023/A:1026188200939 1:CAS:528:DC%2BD3sXotVCksLs%3D (Pubitemid 37368950)
43. G Liuzzo A Buffon LM Biasucci JR Gallimore G Caligiuri A Vitelli S Altamura G Ciliberto AG Rebuzzi F Crea MB Pepys A Maseri 1998 Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina Circulation 98 2370 2376 9832480 1:STN:280:DyaK1M%2FltFGitA%3D%3D (Pubitemid 28549779)
44. D Tousoulis C Antoniades C Stefanadis 2007 Assessing inflammatory status in cardiovascular disease Heart 93 1001 1007 17639118 10.1136/hrt.2006.088211 1:CAS:528:DC%2BD2sXpsFartbo%3D (Pubitemid 47122060)
45. JA Miettinen K Ylitalo P Hedberg J Jokelainen K Kervinen M Niemelä M Säily P Koistinen ER Savolainen H Ukkonen M Pietilä KE Airaksinen J Knuuti O Vuolteenaho TH Mäkikallio HV Huikuri 2010 Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy Heart 96 362 367 19910293 10.1136/hrt.2009.171694
46. JM Hare JH Traverse TD Henry N Dib RK Strumpf SP Schulman G Gerstenblith AN DeMaria AE Denktas RS Gammon JB Hermiller Jr MA Reisman GL Schaer W Sherman 2009 A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction J Am Coll Cardiol 54 2287 2289 10.1016/j.jacc.2009.06.055